A mysterious growth covers three deer on Miller Run Road outside of Griffin, Arizona. The sickly animals are mistaken for scared until they brazenly attack a car, causing a fatal accident. Like everyone else in town, Cass “Scoop” McDaniels has lived in Griffin her entire life. When she is assigned the accident story, her findings are dismissed. The story dies with the people on the road. But Cass doesn’t give up.

In an attempt to control and decrease population, a mutated form of the measles is released. As a precaution, an assurance plan is placed in motion. A sampling of mankind is hidden away in a protective bunker, placed in stasis where they will sleep through the entire event. They are set to awaken one year later to a perfectly balanced world. Nora Lane and Jason Rudolph are two of those who survive. When they wake, like the other survivors, neither of them remember how they got there and why.

A debilitating virus emerges in India and quickly burns its way through the densely populated areas of Asia. The victims suffer for days even weeks on end until finally succumbing. Streets are empty and major cities are mere graveyards. Because of the slow killing nature of the virus, attempts to contain it to one continent seemingly work at first, but human smuggling into infection-free areas cause the virus to break borders globally.

What starts as an emergence of a new virus quickly turns into Mother Nature’s ultimate population control. While attending a seminar at the Ambassador Hotel, Ava Mason is unknowingly exposed to a carrier of a highly contagious virus. The next morning, she wakes to a steady pounding on her door. Within minutes, her home is stormed and she and her three children are apprehended, placed in a van and taken away. They are told nothing. No one is. Ava, her children, and others are brought to the Ambassador and sealed in.

Following a distress call from the state police, Dr. Edward Neil and his team from the Centers for Disease Control enter the small town of Hartworth, Montana. Immediately they encounter a man in a pickup truck holding a quarantine post, his body decimated by a disease like they have never seen. The entire town, population a little under 1000... dead. Men, women and children. The unknown germ hit so fast, the town did not stand a chance of survival.

With increased cases of human to human infection, scientists try to spearhead a Bird Flu Pandemic by merging the H5N1 virus with a similar synthetic strain, one for which there is a cure. The hybrid germ is a success. The results disastrous. The vaccine is ineffective on the new strain and an airborne route of transmission sends the hybrid out of control. The world spirals into a super pandemic. Scientists scurry and find and antidote using the blood of those who show natural immunity.

When an outbreak of H7N2, or as the news calls it, Whitby Fever, begins striking cats and dogs, it is newsworthy but not panic-inducing, until it is confirmed that Whitby Fever has crossed the boundaries, spreading from domestic pets to humans at an astronomical rate. Mills Run, Ohio, is not much different from any other small town. The residents have a bond and kinship. The townspeople brag that Mills Run is isolated, and at times, cut off from the rest of the world. However, not even Mills Run is secluded enough for a global pandemic. 

With no desire to live in a world void of all human life, Faye sets a goal of making it home to die. Then she encounters Dodge and two young boys, who ignite a spark long lost in her: the will to live.   Following radio calls, they discover they are not alone and decide to join a growing camp of survivors. But another discovery threatens their new-found safety and the rules begin to change. As they desperately try to find a safe haven and figure out their place in this new world, Faye must weigh the decision of what she wants to do against what she should do.

A mysterious outbreak has spread quickly, ravaging the globe. The illness is debilitating and deadly. Those who suffer from the virus succumb to a horrible death. Unfortunately, it doesn't end there. The infection transforms them into an unstoppable force of mindless killing machines. At the onset of the epidemic, Nila Carter and her family retreated to her father's cabin in search of safety and seclusion from all that transpired around them. With supplies, fresh water and fertile ground, they were joined by a handful of strangers and positioned themselves for long-term survival.

When Leah and Calvin found out they were expecting, they were over the moon. That day would be one to remember forever… but for more reasons than one. That was the day the world changed. That was the day joy turned to fear. A deadly virus broke out, with many of those infected becoming violent and uncontrollable. And it was spreading fast. Realizing they are no longer safe in their own home, they make a break out of the city to find sanctuary. But when Leah is bitten, Calvin faces the unimaginable struggle of having to take care of their newborn alone. Traveling with the baby and his dead wife in tow, he comes across Hannah, a young girl who lost her family to the virus. They make their way across country together, meeting others trying to find their own sanctuary. They eventually find safety but Calvin soon realizes all is not as it seems and he must make an agonizing choice.