Charlie D is back doing his late-night radio call-in show. It's Halloween - The Day of the Dead. Not a day filled with good memories for Charlie, but the show must go on. His studio guest this evening is Dr. Robin Harris, an arrogant and ambitious "expert in the arts of dying and grieving," who also seems to be auditioning for her own radio talk show. Charlie and Dr. Harris do not hit it off.
Things go from bad to worse when the doctor's ex-lover, Gabe, goes on air to announce that he's about to end his life. Dr. Harris is entirely unsympathetic until she learns that Gabe also has her daughter Kali and plans to poison her too. It will take all of Charlie D's on-air skills to save both Gabe and Kali.