Each year, approximately 16,000 people are murdered in the United States. Seven percent of the killers are female; one of them being Simone Campbell.

In Secrets of a Side Bitch 2, Simone is struggling to keep together the web of lies that she has woven, all in attempts to be the number one woman in Omari Sutton's life. She continues to pull one devious and demented trick after another to maintain her role as Omari's leading lady. Her tower of lies begins crashing down as intricate parts of her schemes begin to unfold. Chance reemerges, threatening Simone's connection to the murder. Desperateness to have Omari's baby sends Simone into such erratic behavior that she starts to make telling mistakes. All the while, Omari is set on making Aeysha's murderer pay for killing the one woman that truly had his heart.