Thirty-eight year old Cassandra is lost, alone, and grieving. Her much loved grandmother, Nell, has just died and Cassandra, her life already shaken by a tragic accident 10 years ago, feels like she has lost everything known and dear to her.

Living on her family’s gorgeous lakeside estate in Cornwall, England, Alice Edevane is a bright, clever, inquisitive, innocent, and precociously talented fourteen-year-old who loves to write stories. But the mysteries she pens are no match for the one her family is about to endure ...One midsummer’s eve, after a beautiful party drawing hundreds of guests to the estate has ended, the Edevanes discover that their youngest son, Theo, has vanished without a trace.

England, 1959: Laurel Nicolson is 16 years old, dreaming alone in her childhood tree house during a family celebration at their home, Green Acres Farm. She spies a stranger coming up the long road to the farm and then observes her mother, Dorothy, speaking to him. And then she witnesses a crime.

Elizabeth and Jackson Shore married young, raised two daughters, and weathered the storms of youth as they built a future together. But after the children leave home, they quietly drift apart. When Jack accepts a wonderful new job offer, Elizabeth puts her needs aside to follow him across the country. Until the sudden death of her father changes everything.

They’re one of the country’s most telegenic couples: beloved TV journalist Sara Lowell and New York’s hottest basketball star, Michael Silverman. Their family and social connections tie them to the highest echelons of the political, medical, and sports worlds - threads that will tangle them up in one of the most controversial and deadly issues of our time. In a clinic on Manhattan’s Upper West Side, a doctor has dedicated his life to eradicating a divisive and devastating disease. One by one, his patients are getting well.