A television talk show host returns to her childhood summer home to rebuild her life after she's fired for falling ratings. The return is bittersweet as the house has been neglected for years. She's flooded with memories of the wonderful summers she spent with her sisters and cousins before a tragic event changed everything. Working to uncover what really happened the last summer they were all together, she reaches out to her family and the women all gather for an uneasy family reunion.

From the outside looking in, Lauren Delaney has a life to envy - a successful career, a solid marriage to a prominent surgeon, and two beautiful daughters who are off to good colleges. But on her 24th wedding anniversary, Lauren makes a decision that will change everything. Lauren won’t pretend things are perfect anymore. She defies the controlling husband who has privately mistreated her throughout their marriage and files for divorce. And as she starts her new life, she meets a kindred spirit - a man who is also struggling with the decision to end his unhappy marriage.

Jennifer Chaise is proud of her life. Coming from nothing, she's used her beauty to her advantage and is swept up in a glamorous world of wealth and privilege as the mistress of a high-flying businessman. But when she walks in on a violent scene in their Las Vegas hotel room, Jennifer knows she can no longer ignore the truth about her boyfriend, and she flees. Desperate to escape the men searching for her, she invents a whole new persona - with a new look and a new name - as she hides out in a small Nevada town.

Between the urban bustle of Denver and the high-stress environment of a career in neurosurgery, Maggie Sullivan has hit a wall. When an emergency high-risk procedure results in the death of a teenager, Maggie finds herself in the middle of a lawsuit - and experiencing levels of anxiety she's never faced before. She knows she needs to slow down before she burns out completely, and the best place she can think to do that is Sullivan's Crossing.

Nikki Burgess survived a terrible marriage and a worse divorce. She's just about given up hope of ever finding happiness. But when her ex-husband suddenly dies, she gets custody of her kids again - and a chance to start over. Dixie McPherson, on the other hand, has had way too much love. She has 11 tennis bracelets, dozens of trinkets, piles of sexy lingerie, and a tarnished reputation when all she ever wanted was true love, a partner, and a family. Carlisle Bartlett is loyal, kindhearted, and the funniest guy slinging drinks in the back of an airplane. But he has an ugly little secret. The only kind of love he's used to comes with bruises.

Adele and Justine have never been close. Born 20 years apart, Justine was already an adult when Addie was born. The sisters love each other, but they don’t really know each other. When Addie dropped out of university to care for their ailing parents, Justine, a successful lawyer, covered the expenses. It was the best arrangement at the time, but now that their parents are gone, the future has changed dramatically for both women.

After her divorce, Charlene Dugan vowed never to get married again - a promise she has kept for twenty-five years. Until the fateful day she finds herself uttering the well-known phrase - "Let's get married!" Almost immediately, Charlene's seemingly perfect life begins unraveling at the seams. Daughter Stephanie's own relationship is about to disintegrate, and she might be just a teensy-weensy bit jealous of her mom. And Charlene seems to be spending more time with her ex-husband than with her fiancé, Dennis.

Clare Wilson is starting over. She's had it with her marriage to a charming serial cheater. Even her own son thinks she's given his father too many chances. With the support of her sisters, Maggie and Sarah, she's ready to move on. Facing her fortieth birthday, Clare is finally feeling the rush of unadulterated freedom. But when a near-fatal car accident lands Clare in the hospital, her life takes another detour. While recovering, Clare realizes she has the power to choose her life's path. With enthusiasm and a little envy, her sisters watch her bloom.

Cassie has sworn off men after yet another bad date though, deep down, she’s still looking for Mr. Right. A long-haired, tattooed biker is definitely not him, so there’s no harm in a few Harley rides through Sonoma. Right? Julie married her high school sweetheart too young and now wonders how her life became all about leaky faucets and checkbook balances. Maybe love isn’t enough to sustain the perfect couple.

Gerri can't decide what's more devastating: learning her rock-solid marriage has big cracks, or the anger she feels as she tries to repair them. Always the anchor for friends and her children, she realizes it's time to look carefully at herself. The journey is more than revealing—it's transforming. Andy has come to believe that a lasting love is out of reach. When she finds herself attracted to a man without any of the qualities that usually appeal to her, she questions everything she thought she wanted in life.