Lincoln Rhyme was once a brilliant criminologist, a genius in the field of forensics - until an accident left him physically and emotionally shattered. But now a diabolical killer is challenging Rhyme to a terrifying and ingenious duel of wits. With police detective Amelia Sachs by his side, Rhyme must follow a labyrinth of clues that reaches back to a dark chapter in New York City’s past - and reach further into the darkness of the mind of a madman who won’t stop until he has stripped life down to the bone.

A serial kidnapper is on the loose in a small town in Maine, targeting wealthy women and demanding a huge ransom in bitcoin for their safe return. When his latest victim’s husband claims that he can’t come up with the money, the word “deadline” takes on a disturbingly literal meaning. The local police are out of their depth, but Colter Shaw takes the lead in the investigation. Soon, he’s using his survivalist instincts to uncover clues and pursue suspects, putting his own life on the line to catch the would-be killer before the countdown hits zero.

Dr. Morton Handler practiced a strange brand of psychiatry. Among his specialties were fraud, extortion, and sexual manipulation. Handler paid for his sins when he was brutally murdered in his luxurious Pacific Palisades apartment. The police have no leads, but they do have one possible witness: seven-year-old Melody Quinn.

Alex Cross is a homicide detective with a PhD in psychology. He works and lives in the ghettos of D. C. and looks like Muhammad Ali in his prime. He's a tough guy from a tough part of town who wears Harris Tweed jackets and likes to relax by banging out Gershwin tunes on his baby grand piano. But he also has two adorable kids of his own, and they are his own special vulnerabilities. Jezzie Flanagan is the first woman ever to hold the highly sensitive job as supervisor of the Secret Service in Washington.

Every day without fail, Travis Devine puts on a cheap suit, grabs his faux-leather briefcase, and boards the 6:20 commuter train to Manhattan, where he works as an entry-level analyst at the city’s most prestigious investment firm. In the mornings, he gazes out the train window at the lavish homes of the uberwealthy, dreaming about joining their ranks. In the evenings, he listens to the fiscal news on his phone, already preparing for the next grueling day in the cutthroat realm of finance. Then one morning Devine’s tedious routine is shattered by an anonymous email: She is dead.