Chemist Elizabeth Zott is not your average woman. In fact, Elizabeth Zott would be the first to point out that there is no such thing as an average woman. But it’s the early 1960s and her all-male team at Hastings Research Institute takes a very unscientific view of equality. Except for one: Calvin Evans; the lonely, brilliant, Nobel–prize nominated grudge-holder who falls in love with—of all things—her mind. True chemistry results.

At the end of the Second World War, Cyril Conroy combines luck and a single canny investment to begin an enormous real estate empire, propelling his family from poverty to enormous wealth. His first order of business is to buy the Dutch House, a lavish estate in the suburbs outside of Philadelphia. Meant as a surprise for his wife, the house sets in motion the undoing of everyone he loves. The story is told by Cyril’s son Danny, as he and his older sister, the brilliantly acerbic and self-assured Maeve, are exiled from the house where they grew up by their stepmother.

At the moment when Voyager 1 is launched into space carrying its famous golden record, a baby of unusual perception is born to a single mother in Philadelphia. Adina Giorno is tiny and jaundiced, but reaches for warmth and light. As a child, she recognizes that she's different: she possesses knowledge of a faraway planet. The arrival of a fax machine enables her to contact her extraterrestrial relatives, beings who have sent her to report on the oddities of earthlings.

After Tova Sullivan’s husband died, she began working the night shift at the Sowell Bay Aquarium, mopping floors and tidying up. Keeping busy has always helped her cope, which she’s been doing since her eighteen-year-old son, Erik, mysteriously vanished on a boat in Puget Sound over thirty years ago. Tova becomes acquainted with curmudgeonly Marcellus, a giant Pacific octopus living at the aquarium. Marcellus knows more than anyone can imagine but wouldn’t dream of lifting one of his eight arms for his human captors—until he forms a remarkable friendship with Tova.

Lydia Quixano Pérez lives in the Mexican city of Acapulco. She runs a bookstore. She has a son, Luca, the love of her life, and a wonderful husband who is a journalist. And while there are cracks beginning to show in Acapulco because of the drug cartels, her life is, by and large, fairly comfortable. When Lydia’s husband’s tell-all profile of Javier, the jefe of the newest drug cartel that has gruesomely taken over the city, is published, none of their lives will ever be the same.

In Shaker Heights, a placid, progressive suburb of Cleveland, everything is planned - from the layout of the winding roads to the colors of the houses to the successful lives its residents will go on to lead. And no one embodies this spirit more than Elena Richardson, whose guiding principle is playing by the rules. Enter Mia Warren - an enigmatic artist and single mother - who arrives in this idyllic bubble with her teenage daughter, Pearl, and rents a house from the Richardsons.

Alix Chamberlain is a woman who gets what she wants and has made a living, with her confidence-driven brand, showing other women how to do the same. So she is shocked when her babysitter, Emira Tucker, is confronted while watching the Chamberlains' toddler one night, walking the aisles of their local high-end supermarket. The store's security guard, seeing a young Black woman out late with a White child, accuses Emira of kidnapping two-year-old Briar. A small crowd gathers, a bystander films everything, and Emira is furious and humiliated. Alix resolves to make things right.

Francesca Ekwuyasi’s debut novel tells the interwoven stories of twin sisters, Kehinde and Taiye, and their mother, Kambirinachi. Kambirinachi feels she was born an Ogbanje, a spirit that plagues families with misfortune by dying in childhood to cause its mother misery. She believes that she has made the unnatural choice of staying alive to love her human family and now lives in fear of the consequences of that decision.

Nuri is a beekeeper and Afra, his wife, is an artist. Mornings, Nuri rises early to hear the call to prayer before driving to his hives in the countryside. On weekends, Afra sells her colorful landscape paintings at the open-air market. They live a simple life, rich in family and friends, in the hills of the beautiful Syrian city of Aleppo - until the unthinkable happens. When all they love is destroyed by war, Nuri knows they have no choice except to leave their home. But escaping Syria will be no easy task: Afra has lost her sight.

Two half sisters, Effia and Esi, unknown to each other, are born into different villages in 18th-century Ghana. Effia is married off to an Englishman and will live in comfort in the palatial rooms of Cape Coast Castle, raising children who will be sent abroad to be educated before returning to the Gold Coast to serve as administrators of the empire. Esi, imprisoned beneath Effia in the castle's women's dungeon and then shipped off on a boat bound for America, will be sold into slavery.