Have you ever wondered why you can be "doing everything right" with your health and still feel inflamed, foggy, or depleted? The more I study longevity, the more I am convinced this has less to do with the latest hack and more to do with something very basic that we almost never talk about: the integrity of the cell membrane. Every process in the human body begins at the level of the cell membrane, and in today's world, that membrane is under constant attack from toxins, infections, chemicals, and everyday stressors.

In this episode of Extend, I sit down with Jess Kane to explore why phosphatidylcholine (PC) may be the most critical nutrient we're not talking about, how modern exposures create "leaky cells," and why nearly all of us are now deficient in the lipids required to keep our DNA, mitochondria, and metabolic pathways safe. We break down the original PK Protocol, the role of PC in detoxification and brain health, and the steps anyone can take to rebuild membrane resilience and restore energy at the cellular level.

Jess Kane is the Chief Marketing Officer and third-generation co-owner of BodyBio, a family-led company pioneering science-backed solutions for cellular health, mitochondrial support, and anti-toxin resilience. She blends strategic insight with deep biochemical knowledge, helping BodyBio earn the trust of more than 35,000 healthcare practitioners worldwide. Jess is dedicated to educating the public on foundational lipids like phosphatidylcholine and the critical role they play in modern health.

What's Discussed:

• (00:00) The "Bubble" Shield: How Your Cell Membrane Actually Works

• (03:31) Leaky Cells: Toxins, Viruses, and the New Epidemic of Cellular Damage

• (04:40) Fats That Build (or Break) Your Cell Membrane

• (11:19) "Our Lipids Are Under Attack": Low-Fat Diets, Modern Toxins, and Metabolic Chaos

• (15:42) Detox, Rebuild, Repeat: Using PC, TUDCA & Glutathione to Repair from the Inside Out

• (27:49) Brain Fog, Acetylcholine, and Why PC Is a Hidden Brain Nutrient

• (33:35) Skin, Aging, and What Healthy Cells Actually Look Like

• (37:23) Seed Oils, Oxidized Fats, and How to Swap In the Right Lipids

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Most people still think GLP-1s are "weight loss shots," but what we are really doing is changing biology at the level of appetite and inflammation, with ripple effects across future generations. In this conversation, I sit down with endocrinologist and obesity specialist Dr. Rocio Salas Whalen to unpack what these medications do inside the body and how to use them responsibly as part of a long-term health strategy.

We get into why "eat less, exercise more" failed so many patients, how family history, hormones, and aging drive obesity, and why GLP-1s must be paired with protein and strength training. We also explore GLP-1's impact on visceral fat, diabetes, brain health, what healthy weight loss looks like on a body composition scan, and how to avoid sarcopenia and the so-called "Ozempic face."

Dr. Rocio Salas-Whalen is a board-certified endocrinologist and obesity-medicine specialist, author of Weightless, and an early adopter of GLP-1 therapies. Her so-called "GPS framework", GLP-1, protein, and strength training, reflects her approach to evidence-based obesity care.

What's Discussed:

(00:00) GLP-1s and Weight Loss

(12:45) The Impact of GLP-1 Hormone

(25:29) Muscle Mass and GLP-1 Importance

(31:46) Optimizing Protein Intake on GLP-1

(43:24) GLP-1 Dosing and Gut Health

(48:20) Mental Health Implications of Weight Loss

(57:16) Weightless Book Pre-Order Announcement

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Most people think heart disease is obvious and predictable, yet women often present with completely different warning signs that traditional testing fails to catch. We now have the tools to identify risk decades earlier and reverse disease before it becomes dangerous.

In this episode of Extend, we sit down with Dr. Suzanne Steinbaum, cardiologist and leading voice in women's cardiovascular prevention, to uncover why standard testing misses female heart disease, how microvascular dysfunction develops long before blockages appear, and why expanded markers like ApoB and HSCRP should replace outdated cholesterol panels. We break down the role of CLEERLY scans, the power of CPET for detecting endothelial dysfunction, and the exact metabolic shifts that happen during perimenopause and menopause.

We also explore how zone two training restores endothelial health, why soft plaque is more dangerous than calcified plaque, and how personalized exercise prescriptions can reverse early disease at any age.

Dr. Suzanne Steinbaum is a pioneering preventive cardiologist, founder of the ADESSO model for women's heart health, and a national leader in microvascular research whose work is redefining how we diagnose, prevent, and reverse cardiovascular disease in women.

What's Discussed:

• (04:15) Why women experience heart disease through microvascular dysfunction rather than classic blockages

• (07:50) How outdated cholesterol panels miss early cardiovascular risk in women

• (12:40) Why ApoB, HSCRP, and metabolic markers reveal the real drivers of plaque

• (17:05) How CLEERLY scans detect dangerous soft plaque that calcium scores miss

• (22:30) Why standard angiograms often look normal in women despite real disease

• (27:55) How CPET testing uncovers endothelial dysfunction and identifies true zone two

• (33:20) How zone two exercise restores arterial flexibility and reverses early disease

• (39:45) Why perimenopause, stress, sleep, and pregnancy history raise cardiovascular risk and demand personalized prevention

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Learn more about Dr. Shah:

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