Exploring GLP-1 agonists in a new light, Matt examines a review that positions these metabolic hormones as potential brain defenders. He details their surprising presence in memory centers and their capacity to combat the "biological rust" of oxidative stress and neuroinflammation.

Matt critically evaluates the gap between robust animal models and the unwritten chapter of human trials, while highlighting the vital link between metabolic health and sleep. He argues that biology is not siloed; supporting the body’s metabolic "power grid" through sleep provides the integrated care the brain needs to withstand complex insults.

Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.

In a supplement industry where trust is critical, Matt uses podcast supporter Puori. Their protein powders are free from hormones, GMOs, and pesticides, with every single batch third-party tested for over 200 contaminants. For protein you can trust, save 20% at puori.com/mattwalker.

Another sponsor is UPLIFT Desk whose V3 Standing Desk helps boost circulation and concentration with a sturdy, customizable design that gets you moving while you work. Visit upliftdesk.com/walker and use code WALKER for 4 free accessories and a 15-year warranty.

As always, if you have thoughts or feedback you’d like to share, please reach out to Matt:

Matt: Instagram @drmattwalker, X @sleepdiplomat,

YouTube: https://www.youtube.com/channel/UCA3FB1fOtY4Vd8yqLaUvolg

Matt examines the critical link between sleep quality and Alzheimer’s pathology. He details the brain's "night shift" - the glymphatic system - which actively flushes out toxins like amyloid beta during deep sleep. Listeners learn how even a single night of deprivation can spike harmful tau levels by 50%, effectively accelerating brain aging.

The discussion pivots to dual orexin receptor antagonists (DORAs), a drug class that quiets wakefulness rather than forcing sedation. Matt highlights research from Dr. Brendan Lucey and Dr. David Holtzman showing these agents may lower toxic proteins and preserve the hippocampus. Despite this therapeutic promise, he emphasizes that natural sleep remains the ultimate gold standard for neuroprotection.

Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.

One of this week's sponsors, LMNT, offers a science-based electrolyte drink with no sugar or artificial ingredients. Try their new limited-time Lemonade Salt flavor, available May 20th! Get eight free sample packs with any order at drinklmnt.com/mattwalker. Stock up on this summer flavor while it lasts!

Another sponsor, Shopify, made launching Matt's merchandise incredibly smooth with its integrated sales system. Shopify simplifies everything from online stores to in-person sales. Start your exclusive trial and see for yourself at shopify.com/mattwalker.

Craving more energy, better metabolism, and immunity? Discover Pique's Nandaka, a ceremonial cacao superfood blend for calm, sustained energy without the crash. Thanks to this wonderful podcast partner, you can now get 20% off for life at piquelife.com/mattwalker using code MattWalker.

As always, if you have thoughts or feedback you’d like to share, please reach out to Matt:

Matt: Instagram @drmattwalker, X @sleepdiplomat,

YouTube: https://www.youtube.com/channel/UCA3FB1fOtY4Vd8yqLaUvolg

In this latest AMA episode, Matt and Dr. Eti Ben Simon explore the complex web connecting sleep to our health and daily lives. They investigate the gut-brain axis, discussing how sleep deprivation alters the microbiome and whether probiotics can restore balance. The conversation also addresses the heavy toll of bereavement, examining the bidirectional link between acute grief and insomnia while offering evidence-based strategies to manage sleep during times of loss.

The discussion shifts to creativity, revealing how REM sleep acts as "informational alchemy" to fuel innovation for artists and scientists alike. Matt and Eti share practical tips for harnessing sleep for breakthroughs, including Edison's famous napping technique. Finally, they cover the dangers of microsleeps - brief, uncontrollable lapses in attention - highlighting the risks of drowsy driving and how emerging technology can help save lives.

Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.

Podcast partner, AG1, is one that Matt relies upon for his foundational nutrition. Their new science-backed Next Gen formula features upgraded probiotics, vitamins, and minerals. Start your subscription today to get a FREE bottle of Vitamin D3+K2 and 5 free travel packs with your first order at drinkag1.com/mattwalker.

In a supplement industry where trust is critical, Matt uses podcast supporter Puori. Their protein powders are free from hormones, GMOs, and pesticides, with every single batch third-party tested for over 200 contaminants. For protein you can trust, save 20% at puori.com/mattwalker.

Another sponsor is UPLIFT Desk whose V3 Standing Desk helps boost circulation and concentration with a sturdy, customizable design that gets you moving while you work. Visit upliftdesk.com/walker and use code WALKER for 4 free accessories and a 15-year warranty.

As always, if you have thoughts or feedback you’d like to share, please reach out to Matt:

Matt: Instagram @drmattwalker, X @sleepdiplomat,

YouTube: https://www.youtube.com/channel/UCA3FB1fOtY4Vd8yqLaUvolg

Eti: X @etoosh, Instagram https://www.instagram.com/eti_bensimon/, or email at etoosh@gmail.com