This is the inside story of the CIA’s secret mind control project, MKULTRA, using never-before-seen testimony from the perpetrators themselves.

Sidney Gottlieb was the CIA’s most cunning chemist. As head of the infamous MKULTRA project, he oversaw an assortment of dangerous―even deadly―experiments. Among them: dosing unwitting strangers with mind-bending drugs, torturing mental patients through sensory deprivation, and steering the movements of animals via electrodes implanted into their brains. His goal was to develop methods of mind control that could turn someone into a real-life “Manchurian candidate.”

In conjunction with MKULTRA, Gottlieb also plotted the assassination of foreign leaders and created spy gear for undercover agents. The details of his career, however, have long been shrouded in mystery. Upon retiring from the CIA in 1973, he tossed his files into an incinerator. As a result, much of what happened under MKULTRA was thought to be lost―until now.

Historian John Lisle has uncovered dozens of depositions containing new information about MKULTRA, straight from the mouths of its perpetrators. For the first time, Gottlieb and his underlings divulge what they did, why they did it, how they got away with it, and much more. Additionally, Lisle highlights the dramatic story of MKULTRA’s victims, from their terrible treatment to their dogged pursuit of justice.

The consequences of MKULTRA still reverberate throughout American society.

John Lisle is a historian of science and the American intelligence community. He was on the show for his previous book, The Dirty Tricks Department, about Stanley Lovell, the OSS precursor to the CIA, and the Masterminds of World War II Secret Warfare. In Vol. 25, No. 2 of Skeptic he wrote about MKULTRA, the CIA program in search of mind control technology. His new book is Project Mind Control: Sidney Gottlieb, the CIA, and the Tragedy of MKULTRA.

In this eye-opening episode, Michael Shermer chats with evolutionist Telmo Pievani about the surprising coexistence—and hybridization—of Neanderthals and Homo sapiens.

They discuss recent scientific discoveries, the evolving understanding of race and biology, and the crucial role of serendipity in advancing scientific knowledge.

This episode offers a nuanced perspective on how unexpected findings continue to reshape our understanding of human origins and the scientific process itself.

Telmo Pievani is Full Professor in the Department of Biology at the University of Padua, where he covers the first Italian chair of Philosophy of Biological Sciences. A leading evolutionist, science communicator, and columnist for Corriere della Sera, he is the author of The Unexpected Life, Creation Without God, and Imperfection (MIT Press). His new book is Serendipity: The Unexpected in Science.

Amid rising concerns about AI, inequality, trade wars, and globalization, New Yorker staff writer and Pulitzer Prize finalist John Cassidy takes a bold approach: he tells the story of capitalism through its most influential critics.

From the Luddites and early communists to the Wages for Housework movement and modern degrowth advocates, Cassidy’s global narrative features both iconic thinkers—Smith, Marx, Keynes—and lesser-known voices like Flora Tristan, J.C. Kumarappa, and Samir Amin.

John Cassidy has been a staff writer at The New Yorker since 1995. He writes a regular column, The Financial Page. He holds degrees from Oxford, Columbia, and New York Universities. His new book is Capitalism and Its Critics: A History from the Industrial Revolution to AI.