Dr. Morton Handler practiced a strange brand of psychiatry. Among his specialties were fraud, extortion, and sexual manipulation. Handler paid for his sins when he was brutally murdered in his luxurious Pacific Palisades apartment. The police have no leads, but they do have one possible witness: seven-year-old Melody Quinn.

The "maddog" murderer who is terrorizing the Twin Cities is two things: insane and extremely intelligent. He kills for the pleasure of it and thoroughly enjoys placing elaborate obstacles to keep police befuddled. Each clever move he makes is another point of pride. But when the brilliant Lieutenant Lucas Davenport, a dedicated cop and a serial killer's worst nightmare, is brought in to take up the investigation, the maddog suddenly has an adversary worthy of his genius.

After more than twenty years away from the law, Joe Hennessy is forced back into the courtroom. Trying to save his vineyard after years of drought, Hennessy returns to practice in Charleston, South Carolina–the city he walked away from after the murder of his ten-year-old son. When one of South Carolina’s most powerful men is charged with possessing stolen artwork, Hennessy steps forward to defend him. But as Hennessy digs into the evidence, as he navigates the truth, he finds that the criminal charges are only the start of their problems.

Years ago, bookseller and mystery aficionado Malcolm Kershaw compiled a list of the genre’s most unsolvable murders, those that are almost impossible to crack - which he titled "Eight Perfect Murders". But no one is more surprised than Mal, now the owner of the Old Devils Bookstore in Boston, when an FBI agent comes knocking on his door one snowy day in February. She’s looking for information about a series of unsolved murders that look eerily similar to the killings on Mal’s old list. And the FBI agent isn’t the only one interested in this bookseller.

Your dad’s not a good person. Your dad killed people, son. These are some of the last words Jack Givins’ father spoke to him before he was whisked away by witness protection, leaving Jack and his mother to pick up the shattered pieces of their lives as best they could. Years later, Jack is a grown man with problems of his own. He’s a talented but struggling author, barely scraping by on the royalties from his moderately successful first book. So when the U.S. Marshals approach him with a lucrative opportunity, he’s in no position to turn them down.

Hen and her husband, Lloyd, have settled into a quiet life in a new house outside of Boston, Massachusetts. Hen (short for Henrietta) is an illustrator and works out of a studio nearby and has found the right meds to control her bipolar disorder. Finally, she’s found some stability and peace. But when they meet the neighbors next door, that calm begins to erode as she spots a familiar object displayed on the husband’s office shelf. The sports trophy looks exactly like one that went missing from the home of a young man who was killed two years ago.

Detective Peter Decker of the LAPD is stunned when he gets the report. Someone has shattered the sanctuary of a remote yeshiva community in the California hills with an unimaginable crime. One of the women was brutally raped as she returned from the mikvah, the bathhouse where the cleansing ritual is performed.

Virgil Flowers kicked around for a while before joining the Minnesota Bureau of Criminal Apprehension. First it was the army and the military police, then the police in St. Paul, and finally Lucas Davenport brought him into the BCA, promising him, "We'll only give you the hard stuff." He's been doing the hard stuff for three years now, but never anything like this.

Alex Cross is a homicide detective with a PhD in psychology. He works and lives in the ghettos of D. C. and looks like Muhammad Ali in his prime. He's a tough guy from a tough part of town who wears Harris Tweed jackets and likes to relax by banging out Gershwin tunes on his baby grand piano. But he also has two adorable kids of his own, and they are his own special vulnerabilities. Jezzie Flanagan is the first woman ever to hold the highly sensitive job as supervisor of the Secret Service in Washington.

By age twenty-four, Letty Davenport has seen more action and uncovered more secrets than many law enforcement professionals. Now a recent Stanford grad with a master’s in economics, she’s restless and bored in a desk job for U.S. Senator Colles. Letty’s ready to quit, but her skills have impressed Colles, and he offers her a carrot: feet-on-the-ground investigative work, in conjunction with the Department of Homeland Security.