Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-459

Overview: Cognitive decline risk may be reduced through modifiable lifestyle factors, creating an opportunity for early intervention in primary care. Join us as we review findings from the US POINTER trial, which evaluated the impact of structured vs. self-guided lifestyle interventions on the risk of cognitive decline in older adults. Come away with tips to apply this evidence in real-world scenarios with your patients.

Episode resource links:

• Baker LD, Espeland MA, Whitmer RA, et al. Structured vs self-guided multidomain lifestyle interventions for global cognitive function: The US POINTER randomized clinical trial. JAMA. 2025;334(8):681-691. doi:10.1001/jama.2025.12923
• Livingston G, Huntley J, Liu KY, et al. Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission. Lancet. 2024;404(10421):572-628. doi:10.1016/S0140-6736(24)01296-0

Guest: Jillian Joseph, MPAS, PA-C

Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-458

Overview: In this episode, we explore the relationship between caffeine consumption and suicide risk. Hear how coffee may offer protective effects—while energy drinks raise concern—and gain practical tips for screening patients for caffeine and substance use as part of suicide risk assessment in primary care.

Episode resource links:

• Low, C.E.; Chew, N.S.M.; Loke, S.; Tan, J.Y.; Phee, S.; Lee, A.R.Y.B.; Ho, C.S.H. Association of Coffee and Energy Drink Intake with Suicide Attempts and Suicide Ideation: A Systematic Review and Meta-Analysis. Nutrients 2025, 17, 1911. https://doi.org/10.3390/ nu17111911

• Costantino, A., Maiese, A., Lazzari, J., Casula, C., Turillazzi, E., Frati, P., & Fineschi, V. (2023). The Dark Side of Energy Drinks: A Comprehensive Review of Their Impact on the Human Body. Nutrients, 15(18), 3922. https://doi.org/10.3390/nu15183922

Guest: Jill M. Terrien PhD, ANP-BC Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-457

Overview: Many patients turn to low- and no-calorie sweeteners to help with weight loss and lower diabetes risk, but do these alternatives actually deliver? In this episode, we review common artificial sweeteners and explore evidence on hunger, cardiovascular, diabetes, and dementia risks to understand how sugar substitutes can impact long-term health outcomes in your patients.

Episode resource links:

• fMRI Data: Nat Metab 7, 574–585 (2025). https://doi.org/10.1038/s42255-025-01227-8
• Adverse effects: Adv Nutr. 2023 Jul;14(4):710-717. doi: 10.1016/j.advnut.2023.05.010
• Dementia Data: Neurology® 2025;105:e214023. doi:10.1212/WNL.0000000000214023
• Stevia: Obes Rev. 2025 Jun;26(6):e13902. doi: 10.1111/obr.13902
• High Fructose Corn Syrup: Nutrition Reviews. 2021;79(2):209-226. doi:10.1093/nutrit/nuaa077

Guest: Robert A. Baldor MD, FAAFP

Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-456

Overview: Experiences of significant pain and anxiety during intrauterine device (IUD) insertion may lead patients to forgo this effective contraceptive option. Listen in as we discuss how to reduce procedural pain, address anxiety, and foster trust using updated guidelines and shared decision-making to improve patient satisfaction and support informed contraceptive choices.

Episode resource links:

• Charles, D. N., Nagarsheth, M., & Oshman, L. (2025). Pain Management for IUD Insertion in Primary Care. American Family Physician, 111(4), 299-301.
• Dempsey, A., Aucoin, C., Stallings, W., Kulangara, A., & Sundstrom, B. (2025). Beyond pain medication: striving toward more patient-centered placement of intrauterine devices. Contraception, 110944.
• Estevez, E., Hem-Lee-Forsyth, S., Viechweg, N. D., John, S., & Menor, S. P. (2024). Advancing pain management protocols for intrauterine device insertion: integrating evidence-based strategies into clinical practice. Cureus, 16(6).
• Hoover, K., & Riley, K. (2025). Pain Management for In-Office Uterine and Cervical Procedures.

Guest: Mariyan L. Montaque, DNP, FNP-BC Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-455

Overview: Microscopic hematuria is common in primary care, but not every patient needs an urgent urology referral. Tune in to learn how to apply the latest evidence-based guidelines to risk-stratify patients and confidently manage workup and follow-up from your clinic, improving care while reducing unnecessary testing.

Episode resource links:

• Barocas DA, Lotan Y, Matulewicz RS, Raman JD, Westerman ME, Kirkby E, Pak L, Souter L. Updates to Microhematuria: AUA/SUFU Guideline (2025). J Urol. 0(0). doi: 10.1097/JU.0000000000004490.

Guest: Robert A. Baldor MD, FAAFP Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-454

Overview: Treating hypertension within the first month can significantly improve long-term blood pressure control. This episode reviews new evidence and practical strategies to help you initiate timely therapy, optimize follow-up, and improve outcomes for patients with newly diagnosed, uncontrolled hypertension. Gain actionable insights to close a critical care gap.

Episode resource links:

• Barrett, R. B., Riesser, B., Martin, B., Sachdev, N., Rakotz, M. K., Sutherland, S. E., & Egan, B. M. (2025). Treatment in the First Month After Hypertension Diagnosis Improves Blood Pressure Control. Hypertension (Dallas, Tex. : 1979), 82(6), 1129–1136. https://doi.org/10.1161/HYPERTENSIONAHA.124.23508
• For your patients: 10 Ways to Control High Blood Pressure Without Medication
• For your patients: Natural Ways to Lower Blood Pressure

Guest: Jill M. Terrien PhD, ANP-BC Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-453

Overview: Many patients are still hesitant about the shingles vaccine, but the benefits go far beyond preventing a painful rash. Hear how varicella zoster vaccination can also reduce the risks of postherpetic neuralgia, dementia, and cardiovascular events, giving you powerful tools to guide more informed patient decisions.

Episode resource links:

• Dementia: Neurol Sci. 2024 Jan;45(1):27-36. doi: 10.1007/s10072-023-07038-7 CV: J Infect Dis. 2025 Feb 28:jiaf105. doi: 10.1093/infdis/jiaf105

Guest: Robert A. Baldor MD, FAAFP Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-452

Overview: The healthcare landscape is evolving rapidly, and clinicians are navigating conflicting guidance on established, evidence-based recommendations. Recent news suggest acetaminophen use during pregnancy causes autism spectrum disorder (ASD), which is not the consensus of medical experts based on available data. When guidance from various sources conflicts with established research, clinicians face challenges in providing evidence-based care. Join us to review the current evidence on acetaminophen and ASD risk.

Episode resource links:

• Ahlqvist VH, Sjöqvist H, Dalman C, et al. Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability. JAMA. 2024;331(14):1205–1214. doi:10.1001/jama.2024.3172

• Damkier, P., Gram, E. B., Ceulemans, M., Panchaud, A., Cleary, B., Chambers, C., Weber-Schoendorfer, C., Kennedy, D., Hodson, K., Grant, K. S., Diav-Citrin, O., Običan, S. G., Shechtman, S., & Alwan, S. (2025). Acetaminophen in Pregnancy and Attention-Deficit and Hyperactivity Disorder and Autism Spectrum Disorder. Obstetrics and gynecology, 145(2), 168–176. https://doi.org/10.1097/AOG.0000000000005802

• Ji Y, Azuine RE, Zhang Y, et al. Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood. JAMA Psychiatry. 2020;77(2):180–189. doi:10.1001/jamapsychiatry.2019.3259

• Hirota T, King BH. Autism Spectrum Disorder: A Review. JAMA. 2023;329(2):157–168. doi:10.1001/jama.2022.23661

• Liu, X., Zou, M., Sun, C., Wu, L., & Chen, W. X. (2022). Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression. Journal of autism and developmental disorders, 52(2), 522–539. https://doi.org/10.1007/s10803-021-04951-8

• DSM-5-TR: Neurocognitive Disorders Supplement; October 2022. https://psychiatryonline.org/pb-assets/dsm/update/DSM-5-TR_Neurocognitive-Disorders-Supplement_2022_APA_Publishing.pdf

• https://www.npr.org/sections/shots-health-news/2025/09/06/nx-s1-5532143/hhs-responds-to-report-about-autism-and-acetaminophen

Guest: Susan Feeney, DNP, FNP-BC, NP-C Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com