Josh Witteldorf is a PhD in physics who pivoted to researching aging and investigated the evolutionary reasons for aging and human lifespan. He's written the book Cracking the Aging Code.

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Timestamps:00:00 Intro00:30 How Josh, as a physicist, got into aging research04:35 Why aging is an evolutionary program13:50 Why humans die and age20:45 Bon Charge sponsorship21:35 Why did aging evolve as an adaptation24:40 Species that are biologically immortal30:25 Shocking way group selection selects for aging and death33:55 How predator-prey relations select for aging43:15 Can humans control our own evolution48:15 A long-term human calorie restriction experiment in Biosphere 252:50 Insulin’s effects on aging 55:20 mTOR and aging57:15 Can you deprogram aging and extend lifespan01:10:00 Gene editing01:15:15 Josh’s predictions for the future

Josh Mitteldorf blog: https://scienceblog.com/joshmitteldorf/

Josh's book Cracking the Aging Code: https://amzn.to/4mFmC6m

Start rewinding your biological clock: https://www.siimland.co/course

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Timestamps:00:00 Intro00:32 Resting heart rate02:27 hsCRP03:32 VLDL03:52 LDL particle count04:31 Homocysteine 05:26 Respiratory rate06:30 VO2 max07:36 Body fat percentage09:18 BMI11:57 HRV14:14 Waist circumference and waist to hip ratio16:00 Visceral fat mass and liver fat18:42 White blood cells20:35 Albumin21:11 Muscle mass22:40 Grip strength24:15 Appendicular lean mass index25:31 Creatinine27:55 eGFR29:20 Cystatin C29:32 Biological age tests31:45 Speed of aging test32:45 Phenoage34:25 Bone density36:00 Lung force36:59 Lp(a)38:15 Oxidized LDL39:00 Testosterone43:40 SHBG45:22 Estradiol (E2)46:42 Resting metabolic rate49:00 Body temperature51:48 Liver enzymes (ALT, AST, GGT, ALP)53:14 ApoB55:10 IGF-157:30 ApoA59:30 Calcium score in the arteries (CAC)01:00:46 Carotid intima media thickness (CIMT)01:03:18 Iodine01:05:09 Thyroid hormones (T3 and T4)01:08:00 Progesterone and pregnenolone01:08:51 Thyroid-stimulating hormone (TSH)01:09:47 BNP (cardiac stress)01:10:22 Hemoglobin01:11:22 Iron and ferritin01:12:56 Uric acid01:13:49 HDL cholesterol01:14:53 HbA1c01:15:39 Fasting insulin01:15:58 Fasting glucose01:17:23 Fructosamine01:18:11 Triglycerides01:19:07 Omega-3 index01:20:26 Omega-6-to-3 ratio01:21:01 Red cell distribution width (RDW)01:21:22 Platelets01:22:22 Mean corpuscular volume (MCV)01:22:39 LDL cholesterol01:23:18 Mean corpuscular hemoglobin (MCH)01:23:33 Blood urea nitrogen (BUN)01:23:57 DHEA-S01:24:52 Vitamin D01:26:07 HOMA-IR01:26:26 Red blood cells01:26:38 Hematocrit01:27:01 Erythrocyte sedimentation rate (ESR)01:27:38 LP-PLA201:28:15 Electrolytes01:29:09 Total cholesterol01:29:23 B vitamins01:30:29 Total iron binding capacity (TIBC) and transferrin saturation01:31:00 Heavy metals01:32:48 Microplastics01:34:54 Cortisol01:36:10 TNF-alpha01:36:50 How much can you lift?01:39:22 Cooper test01:40:25 Microbiome diversity01:42:08 Conclusion

100 supplements ranked worst to best: https://youtu.be/W8DZbYyuDmA

Greg Potter, PhD, is a circadian rhythm and time-restricted eating expert who researches sleep, circadian rhythms, and time-restricted eating

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Timestamps:00:00 Intro01:05 Circadian clock dysfunction and hallmarks of aging10:35 How the circadian clocks affect aging and lifespan17:00 Bon Charge sponsorship17:55 Why clock dysfunction contributes to aging24:50 What causes circadian clock dysfunction30:00 NAD metabolism and clock function31:30 Calorie restriction and meal timing36:00 Night owls vs morning larks39:35 Shift work42:18 Melatonin supplementation46:00 Clock enhancing nutraceuticals49:10 Should you supplement melatonin at old age59:45 Morning cortisol circadian rhythm01:04:50 Sunlight and UV & infrared light exposure01:09:05 How to keep your circadian clock system working well during aging

Greg Potter YouTube channel: https://www.youtube.com/@gregpotterphd

Greg Potter PhD Instagram: https://www.instagram.com/gregpotterphd/

Exercise roundtable with Greg and Nic: https://youtu.be/8eW5gNiSxUU

Longevity supplement roundtable with Greg and Nic: https://youtu.be/OBPacg_tVuQ