Josh Witteldorf is a PhD in physics who pivoted to researching aging and investigated the evolutionary reasons for aging and human lifespan. He's written the book Cracking the Aging Code.

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Timestamps:00:00 Intro00:30 How Josh, as a physicist, got into aging research04:35 Why aging is an evolutionary program13:50 Why humans die and age20:45 Bon Charge sponsorship21:35 Why did aging evolve as an adaptation24:40 Species that are biologically immortal30:25 Shocking way group selection selects for aging and death33:55 How predator-prey relations select for aging43:15 Can humans control our own evolution48:15 A long-term human calorie restriction experiment in Biosphere 252:50 Insulin’s effects on aging 55:20 mTOR and aging57:15 Can you deprogram aging and extend lifespan01:10:00 Gene editing01:15:15 Josh’s predictions for the future

Josh Mitteldorf blog: https://scienceblog.com/joshmitteldorf/

Josh's book Cracking the Aging Code: https://amzn.to/4mFmC6m

Start rewinding your biological clock: https://www.siimland.co/course

Get my free bloodwork cheat sheet: https://www.siimland.co/bloodwork-cheat-sheet

Timestamps:00:00 Intro00:32 Resting heart rate02:27 hsCRP03:32 VLDL03:52 LDL particle count04:31 Homocysteine 05:26 Respiratory rate06:30 VO2 max07:36 Body fat percentage09:18 BMI11:57 HRV14:14 Waist circumference and waist to hip ratio16:00 Visceral fat mass and liver fat18:42 White blood cells20:35 Albumin21:11 Muscle mass22:40 Grip strength24:15 Appendicular lean mass index25:31 Creatinine27:55 eGFR29:20 Cystatin C29:32 Biological age tests31:45 Speed of aging test32:45 Phenoage34:25 Bone density36:00 Lung force36:59 Lp(a)38:15 Oxidized LDL39:00 Testosterone43:40 SHBG45:22 Estradiol (E2)46:42 Resting metabolic rate49:00 Body temperature51:48 Liver enzymes (ALT, AST, GGT, ALP)53:14 ApoB55:10 IGF-157:30 ApoA59:30 Calcium score in the arteries (CAC)01:00:46 Carotid intima media thickness (CIMT)01:03:18 Iodine01:05:09 Thyroid hormones (T3 and T4)01:08:00 Progesterone and pregnenolone01:08:51 Thyroid-stimulating hormone (TSH)01:09:47 BNP (cardiac stress)01:10:22 Hemoglobin01:11:22 Iron and ferritin01:12:56 Uric acid01:13:49 HDL cholesterol01:14:53 HbA1c01:15:39 Fasting insulin01:15:58 Fasting glucose01:17:23 Fructosamine01:18:11 Triglycerides01:19:07 Omega-3 index01:20:26 Omega-6-to-3 ratio01:21:01 Red cell distribution width (RDW)01:21:22 Platelets01:22:22 Mean corpuscular volume (MCV)01:22:39 LDL cholesterol01:23:18 Mean corpuscular hemoglobin (MCH)01:23:33 Blood urea nitrogen (BUN)01:23:57 DHEA-S01:24:52 Vitamin D01:26:07 HOMA-IR01:26:26 Red blood cells01:26:38 Hematocrit01:27:01 Erythrocyte sedimentation rate (ESR)01:27:38 LP-PLA201:28:15 Electrolytes01:29:09 Total cholesterol01:29:23 B vitamins01:30:29 Total iron binding capacity (TIBC) and transferrin saturation01:31:00 Heavy metals01:32:48 Microplastics01:34:54 Cortisol01:36:10 TNF-alpha01:36:50 How much can you lift?01:39:22 Cooper test01:40:25 Microbiome diversity01:42:08 Conclusion

100 supplements ranked worst to best: https://youtu.be/W8DZbYyuDmA

Greg Potter, PhD, is a circadian rhythm and time-restricted eating expert who researches sleep, circadian rhythms, and time-restricted eating

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Timestamps:00:00 Intro01:05 Circadian clock dysfunction and hallmarks of aging10:35 How the circadian clocks affect aging and lifespan17:00 Bon Charge sponsorship17:55 Why clock dysfunction contributes to aging24:50 What causes circadian clock dysfunction30:00 NAD metabolism and clock function31:30 Calorie restriction and meal timing36:00 Night owls vs morning larks39:35 Shift work42:18 Melatonin supplementation46:00 Clock enhancing nutraceuticals49:10 Should you supplement melatonin at old age59:45 Morning cortisol circadian rhythm01:04:50 Sunlight and UV & infrared light exposure01:09:05 How to keep your circadian clock system working well during aging

Greg Potter YouTube channel: https://www.youtube.com/@gregpotterphd

Greg Potter PhD Instagram: https://www.instagram.com/gregpotterphd/

Exercise roundtable with Greg and Nic: https://youtu.be/8eW5gNiSxUU

Longevity supplement roundtable with Greg and Nic: https://youtu.be/OBPacg_tVuQ

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland

Timestamps:

00:00 Intro00:22 Dr Robbins background in longevity research01:57 What is cell senescence07:52 Benefits of senescent cells early in life09:07 Does eliminating senescent cells increase lifespan14:50 How to eliminate senescent cells17:35 Most researched senolytics22:15 Can you reverse the age of senescent cells24:00 Immune system and aging26:20 Rapamycin29:20 Practical tips to reduce your senescent cell burden33:50 Are GLP-1 receptor agonists anti-aging drugs36:55 Should people take senolytics41:05 Gene therapies for senescent cells50:45 What things need to be focused on for breakthroughs in longevity research

Dr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Masonic Institute on the Biology of Aging and Metabolism (MIBAM) and the Medical Discovery Team on the Biology of Aging at the University of Minnesota. Paul Robbins Research lab: https://robbins.umn.edu/

Full routine to go from average to top 1% health: https://youtu.be/dHfhTQSBAfg

➡ Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/Start rewinding your biological clock: https://www.siimland.co/course

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland

Timestamps:00:00 Intro00:20 Greg and Siim's background06:35 Our opinion on what’s the best diet12:50 What is most important: how much you eat, what you eat, when you eat18:15 Bon Charge sponsorship19:05 How important is the timing of when you eat42:30 Best diet for top 1% longevity, top 1% athletics and general wellbeing53:00 How to structure your calories, protein, carbs and fats01:07:15 Better and worse forms of protein, carbs and fats01:30:20 Low protein vs high protein for longevity02:09:25 Low carb vs plant-based diet02:10:00 Diet tribalism on social media02:33:00 Final words

Exercise roundtable with Greg and Nic: https://youtu.be/8eW5gNiSxUU

Longevity supplement roundtable with Greg and Nic: https://youtu.be/OBPacg_tVuQ

Greg Potter YouTube channel: https://www.youtube.com/@gregpotterphd

Greg Potter PhD Instagram: https://www.instagram.com/gregpotterphd/

Physionic Instagram: https://www.instagram.com/physionic_phd/

Physionic YouTube channel: https://www.youtube.com/@PhysionicStart rewinding your biological clock: https://www.siimland.co/courseP.S. This is not professional medical advice and should not be taken as such. The creator of this video is not held accountable for your health. Consult your doctor first.

Get your free personalized health review: https://www.siimland.co/review

Timestamps:00:00 Intro01:10 Summary of our biomarker differences02:30 Fitness markers09:45 Body composition markers14:45 Inflammation and immune markers19:30 Metabolic health markers24:15 Cardiovascular markers36:30 Kidney markers43:45 Liver markers47:00 Hormone markers53:20 Experimental longevity tests56:45 PhenoAge biological age test01:01:40 RecapMy Evidence-Based Longevity Routine: https://youtu.be/4xkRcfeGDooStart rewinding your biological clock: https://www.siimland.co/course

Get my 2025 supplement guide: https://www.siimland.co/supplement-list-2025

Timestamps:00:00 Intro00:16 Ca-AKG01:00 NAD Boosters02:54 Senolytics03:53 Glycine and trimethylglycine04:54 Glucosamine sulfate05:25 Taurine05:48 MSM and chondroitin sulfate06:18 Turmeric06:50 Ashwagandha07:52 Citrulline08:02 Thiamine08:40 Chromium09:14 Melatonin09:44 Theanine10:00 Rhodiola rosea10:24 Vitamin C11:01 Methylated B vitamins11:20 Ginger11:37 Sulforaphane11:52 Resveratrol and pterostilbene13:15 Rapamycin14:16 Metformin15:25 Spermidine and wheat germ16:50 Multivitamin17:40 Vitamin E tocotrienols18:10 Methylene blue18:49 Nicotine19:30 Lutein & zeaxanthin & lycopene20:41 Beta-carotene21:40 Molecular hydrogen22:10 Cocoa flavanols22:27 Spirulina22:58 Berberine23:25 Creatine24:14 Vitamin E tocopherol24:27 Aspirin25:35 Vitamin D326:45 Magnesium27:38 Collagen peptides28:10 Glutathione28:47 Vitamin K29:09 Carnosine29:36 Whey protein29:56 Amino acids31:09 Glutamine31:40 Psyllium husk32:08 Caffeine33:33 Aged garlic extract34:01 Ergothioneine34:46 Red yeast rice extract35:39 Tongkat ali36:06 DHEA36:40 Lithium37:52 Omega-338:18 SIRT638:41 NAC39:19 CoQ1040:01 PQQ40:32 Hyaluronic acid41:02 Boron41:20 Inositol41:30 Electrolytes42:35 Zinc43:08 Ginseng43:19 Shilajit43:44 Gingko biloba44:09 EGCG44:42 Tribulus terrestris45:15 Turkesterone45:45 MCT oil47:00 Iron47:40 GHK-Cu48:55 Iodine50:01 Calcium50:31 Beta-alanine51:09 HMB51:41 Saffron52:25 Probiotics and prebiotics53:45 Nattokinase54:32 Digestive enzymes55:11 Astaxanthin

Top 15 Evidence-Based Supplements: https://youtu.be/jrozJ6oMEjo

Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/

Timestamps:

00:00 Intro01:10 New research in cancer04:35 Circadian rhythms and chemotherapy07:55 Does living close to golf courts increase Parkinson’s and cancer risk11:35 Does glyphosate increase cancer risk13:40 Do you need to worry about cancer if you’re young17:20 Why cancer rates are rising in younger people21:00 Join my Skool community 22:10 Can stress and negative emotions cause cancer27:40 What does it feel to have cancer in the early stages30:35 How much exercise to reduce cancer risk35:15 Should you filter your tap water36:30 Difference between a benign tumor and cancerous tumor40:15 Can the body get rid of cancer on its own42:10 Should you avoid milk and cheese45:25 Processed meat and cured meats47:15 Why can some people live years with cancer49:00 Cancer risk from everyday household items51:35 Can you reverse damage from smoking and alcohol in the context of cancer54:15 Specific biomarkers for cancer risk56:15 Any supplements that have cancer preventive effectsDr Joe Zundell YouTube channel: https://www.youtube.com/@dr.joezundell

Dr Joe Zundell Instagram: https://www.instagram.com/dr.joezundell/Start rewinding your biological clock: https://www.siimland.co/courseP.S. This is not professional medical advice and should not be taken as such. The creator of this video is not held accountable for your health. Consult your doctor first.