In this episode of The Skin Science Podcast, Thomas M. Hitchcock, Ph.D., Chief Science Officer, speaks with Angela Wilson McDonald, Global VP, Education and Customer Success, about why BIOJUVE is not skincare.

The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.

In this episode of The Skin Science Podcast, Thomas M. Hitchcock, Ph.D., Chief Science Officer, speaks with special guests, Jigna Patel, MD, of Vedaskin, and Ansar Mahmood, MD, Consultant Trauma & Orthopedic Surgeon, about regenerative medicine and how it pertains to skin science.

The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.

In this episode of The Skin Science Podcast, Thomas M. Hitchcock, Ph.D., Chief Science Officer, speaks with special guest, Jigna Patel, MD, of Vedaskin, and Angela Wilson McDonald, Global VP, Education and Customer Success, about whether skin aging is correlated to the skin's microbiome.

The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.

0:00 Intro
1:24 Special Guest, Jigna Patel MD
5:21 Introduce topic, aging & the skin microbiome
11:10 Aging as a disease state
15:15 Band-aid treatments vs reversing aging
19:50 Relationship between skin microbiome and age
24:40 Commensal vs pathogenic in whole ecosystems
28:20 Nurturing the skin's natural properties
32:45 Microbe diversity and age
37:18 Gut vs skin microbiomes in age
42:27 Closing remarks

Reference at 37:50: Woo YR, Kim HS. Interaction between the microbiota and the skin barrier in aging skin: a comprehensive review. Front Physiol. 2024;15:1322205. doi:10.3389/fphys.2024.1322205

In this episode of The Skin Science Podcast, Thomas M. Hitchcock, Ph.D., Chief Science Officer, speaks with special guests, Angela Wilson McDonald, Global VP, Education and Customer Success, and Brian Jones, Ph.D., Global VP, R&D Pharma and Biomedical Innovation, about what the scientific literature says about microneedling, acne and granulomas.

The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.

0:00 Introduction and disclaimers
1:04 Special guest, Dr. Brian Jones
3:13 Define episode topic: the science behind microneedling and acne
6:00 Social media video detailing a skin reaction months after a microneedling treatment
9:12 What is acne-prone skin?
13:11 Can acne be spread?
14:49 Clip from S1 Ep2 "Acne" with Dr. James Leydon
17:27 What causes acne?
21:20 Inflammation and acne
23:44 Microneedling studies in individuals with acne-prone skin
28:16 Lack of scientific evidence that microneedling worsens acne
35:15 Granulomas and risks of microneedling topicals into skin
40:33 Allergic reactions to metals
43:48 Acne is a multifactorial condition
45:09 Return to discussion about social media video
49:00 Microneedling practices associated with granulomas
51:20 Closing remarks

REFERENCES

24:00 Mehran, G., Sepasgozar, S., Rohaninasab, M., Goodarzi, A., Ghassemi, M., Fotooei, M., & Behrangi, E. (2019). Comparison between the therapeutic effect of microneedling versus tretinoin in patients with comedonal acne: a randomized clinical trial. Iran J Dermatol, 22, 87–91. https://www.iranjd.ir/article_100199_17b3901512f6a7d987df9c24299a856d.pdf

25:49 Alqam, M. L., Jones, B. C., & Hitchcock, T. M. (2023). Topical application of skin biome care regimen containing live cultures and ferments of Cutibacterium acnes defendens strain XYCM42 and the impact on clinical outcomes following microneedle-induced skin remodeling. The Journal of Clinical and Aesthetic Dermatology, 16(12), 18–30. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729805/pdf/jcad_16_12_18.pdf

31:24 Alqam, M. L., Jones, B. C., & Hitchcock, T. M. (2023). Study to determine the safety and efficacy of microneedling as an effective treatment for acne vulgaris. Skin Health and Disease, 3(5), e264. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10549865/pdf/SKI2-3-e264.pdf

35:21 Heck, E., & Traboulsi, D. (2022). A case of a delayed granulomatous reaction on the face following microneedling: A case report. SAGE Open Medical Case Reports, 10, 2050313X221102489. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178993/pdf/10.1177_2050313X221102489.pdf

35:47 Yadav, S., & Dogra, S. (2016). A cutaneous reaction to microneedling for postacne scarring caused by nickel hypersensitivity. Aesthetic Surgery Journal, 36(4), NP168–NP170. https://doi.org/10.1093/asj/sjv229

38:40 Handal, M., Kyriakides, K., Cohen, J., & Hoffman, C. (2023). Sarcoidal granulomatous reaction

In this episode of The Skin Science Podcast, Thomas M. Hitchcock, Ph.D., Chief Science Officer, speaks with Jigna Patel, MD, of Vedaskin, and Angela Wilson McDonald, Global VP, Education and Customer Success, about retinoids and their impact on the skin's microbiota.

The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.


0:00 Intro
1:06 Special guest, Dr. Jigna Patel
4:57 Holistic approaches
6:10 Retinoids & patient considerations
10:12 Safety concerns
13:40 What do retinoids do?
18:29 Changing approaches to skincare
21:06 Do modern societal norms accelerate aging?
25:25 Accepting progression in skincare
31:55 Intermission for puzzle of the day
35:28 How Xycrobe technology came to be
43:50 Using commensal microbes for better skin health
48:20 Translating science into patient care
53:59 C. acnes and retinoid receptors
56:50 Closing remarks

In this episode of The Skin Science Podcast, Thomas M. Hitchcock, Ph.D., Chief Science Officer, speaks with Angela Wilson McDonald, Global VP, Education and Customer Success, and Brian Jones, Ph.D., VP, R&D and Biomedical Innovation, about biome boosted microneedling and the clinical study to support it.

The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.


0:00 Introduction
2:50 Before/after photo from Crown "Biome-boosted microneedling" clinical study
6:34 Story behind the SkinPen + BIOJUVE biome-boosted microneedling study
9:50 Treatment of acne scars
13:08 Optimal environment for skin remodeling
16:40 Philosophy of the BIOJUVE regimen
19:00 How topicals influence skin physiology
23:03 Study design and rationale
28:20 Results
30:30 Before/after photos
33:20 Opportunity to enhance microneedling results
38:25 Improvement beyond acne scarring
40:20 Remodeling process
43:50 Closing remarks


Alqam, M. L., Jones, B. C., & Hitchcock, T. M. (2023). Topical application of skin biome care regimen containing live cultures and ferments of Cutibacterium acnes defendens strain XYCM42 and the impact on clinical outcomes following microneedle-induced skin remodeling. Journal of Clinical and Aesthetic Dermatology, 16(12), 18–30. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10729805/pdf/jcad_16_12_18.pdf

Hosted by Thomas Hitchcock, Ph.D., Chief Science Officer at Crown Laboratories, The Skin Science Podcast is a monthly podcast that covers topics relating to skin health. The series digs into hot topics within dermatology and aesthetics and challenges the audience to think a bit differently about current skin treatment options. In this episode, Dr. Hitchcock, Angela Wilson McDonald, and special guest, Dr. Doris Day, discuss Rosacea.

The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.

0:00 Introduction
0:45 Dr. Doris Day
2:20 What is rosacea?
5:10 Demodex theory of rosacea
8:55 Bacteria associated with rosacea
12:35 Inflammatory triggers
13:41 Systemic biologics
15:45 Impacts of different topicals
20:25 Role of stress in rosacea
26:34 Closing statements

In this episode of The Skin Science Podcast, Thomas M. Hitchcock, Ph.D., Chief Science Officer, speaks with David Weir, MSN, APRN, NP-C, about exosomes and the challenge of limited substantiated science.

The Skin Science Podcast is intended to provide listeners with information regarding various topics in the field of skin science. None of the content in this podcast should be interpreted or construed as professional or medical advice. Further, the views and opinions expressed by guests are their own and do not represent those of Crown Laboratories, Inc., and the appearance of any guest on the podcast does not imply an endorsement of the guest or any particular entity they represent.


0:00 Introduction
0:55 Guest, David Weir
3:00 Exosomes in the aesthetic industry
7:12 Studies with exosomes
10:40 Questions of safety and dosage
12:50 Exosome sources
18:10 How genetics play into exosome contents
24:40 Responsibilities of consumers, providers, and companies
28:40 What questions patients should ask about exosome products
33:40 Concluding statements