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The year is 1880. Two hundred years after the trials in Salem, witches Adelaide Thom and Eleanor St Clair finally feel safe and have opened a tea shop in Manhattan, specialising in cures, palmistry and potions. When an enchanting young woman called Beatrice joins the witches as an apprentice, she soon proves indispensable, but her new life is marred by strange occurrences. She sees things no one else can see. She hears voices no one else can hear. Objects appear out of thin air, as if gifts from the dead.

The year is 1880. Two hundred years after the trials in Salem, Adelaide Thom has left her life in the sideshow to open a tea shop with another young woman who feels it's finally safe enough to describe herself as a witch: a former medical student and gardien de sorts (keeper of spells), Eleanor St. Clair. Together they cater to Manhattan's high society ladies, specializing in cures, palmistry and potions - and in guarding the secrets of their clients.

The Virgin Cure begins in the tenements of lower Manhattan in the year 1871. A series of betrayals lead Moth, at only twelve years old, to the wild, murky world of the Bowery, where eventually she meets Miss Everett, the owner of a brothel simply known as "The Infant School." Miss Everett caters to gentlemen who pay dearly for companions who are "willing and clean," and the most desirable of them all are young virgins like Moth.

The Birth House is the story of Dora Rare, the first daughter to be born in five generations of Rares. As a child in an isolated village in Nova Scotia, she is drawn to Miss Babineau, an outspoken Acadian midwife with a gift for healing. Dora becomes Miss B.’s apprentice, and together they help the women of Scots Bay through infertility, difficult labours, breech births, unwanted pregnancies and even unfulfilling sex lives.

As the witches roast chestnuts and melt lead to see their fate, a series of odd messengers land on their doorstep bearing invitations for a New Year's Eve masquerade hosted by a woman they've never met. Gossip, dreams and portents follow, leading the witches to question the woman's motives. Is she as benevolent as she seems or is she laying a trap? And so, as Gilded-Age New York prepares to ring in the new year, the witches don their finery and head for the ball, on the hunt for answers that might well be the end of them.

Weaving together family history, genetic discovery, and scenes from her life, Ami McKay tells the compelling, true-science story of her own family's unsettling legacy of hereditary cancer while exploring the challenges that come from carrying the mutation that not only killed many people you loved, but might also kill you.