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In the dead of night, a young woman is abandoned on the steps of Orchard Country Hospital and a man is seen fleeing. Nobody knows their identities. When the young woman dies, Doctor Frances Brakespeare is keen to solve the mystery of her identity and find those responsible for her fatal injuries. With her mother’s failing health and a very patient admirer, the last thing Frances needs is a dream job offer from a top London hospital. Torn, Frances must decide what matters more to her; her career or remaining in a small town she’s become attached to surrounded by those who need and love her…

When headstrong Nadine Burton learns that the woman, she thought was her Indian Ayah was in fact her mother, she rebels against her father in a flamboyant display of disrespect and dares to dance with her two local best friends at a public party. Her father, local official, Roland Frederick Burton is furious. He arranges for her to be exiled from India and married off to Australian Martin McPherson, owner of a rubber plantation north of Singapore.

Bristol, 1939. School leaver Maisie Miles suspects her father, a small-time crook, has an ulterior motive for insisting she gets a job at the W. D. & H. O. Wills tobacco factory but keeps it to herself. She's befriended by effervescent Phyllis Mason and kind-hearted Bridget Milligan who take pity on her and take Maisie under their wing. But beneath their happy-go-lucky exteriors, they all harbour dreams and worries about what the future holds.

Bristol 1936. Jenny Crawford has resigned herself to a loveless marriage living hand to mouth with their two children. Like many others, husband Roy struggles to find work at the docks but a chance encounter turns the family's fortunes around. Not only does he get regular work but they are also allocated a council house on Coronation Close on the outskirts of the city. Jenny and the children are overjoyed, this is the fresh start she could only ever dream of. But trouble feels never too far away.

The year is 1937 and the country is still reeling from the abdication of King Edward the Eighth the year before. His brother, the Duke of York, has become King George the Sixth and will be crowned in May. The country is on a high. Union Jacks are being dusted off and bunting is being made. Thelma, Jenny and residents of Coronation Close are all a buzz with planning the street parties and celebrations for the great day. But behind every door shameful secrets and sins linger on Coronation Close, just bubbling to expose themselves.

Coronation Close survives the brutal Bristol Blitz but with rationing, call up papers and new rules and regulations everyone’s lives are changed forever. Resident do-gooder PC Percy Routledge's obsession with rules being upheld finds him spying and reporting fellow neighbours on the slightest infraction whilst his poor brow-beaten wife, Margaret can only watch on in shameful silence. It’s whispered that one day he’ll get his comeuppance…

Bristol 1938. A shadowy presence overshadows Coronation Close, watching and waiting. Jenny Crawford is the first to notice the stranger and wonders why his attention is fixed on Thelma Dawson’s house. When challenged he makes a hasty retreat. Meanwhile Thelma is having trouble with her precocious daughter Mary who is about to leave school and start work. Mary considers herself an adult but to Thelma she’s still a little girl; an attitude resented by her daughter.

Doctor Frances Brakespeare continues to settle into her new life in rural Somerset at Orchard Cottage Hospital, striving to improve the medical treatments on offer to the community. After successfully establishing a mother and baby clinic, Frances is determined to move with the times and add family planning advice to her roster – but are the residents of Norton Dene ready for such progress or will she face opposition?

Born in the workhouse and adopted by a former suffragette, Frances Brakespeare was encouraged from an early age to be strong, independent and to pursue a career as a doctor. The tragic loss of the love of her life in the Great War propels Frances to commit to her one true vocation. Rebelling against the unfair treatment of female doctors Frances is dismissed from her London post and things continue to take a turn for the worse when Izzy, her benefactress dies and Frances finds herself homeless.

1930 - Douro Valley, Portugal. Twelve-year-old Catherine is watching the Rabalo race in Porto when the sound of a shot being fired changes her life forever. Her beloved mother, mistress for some years to Walter Shellard, a Bristol-based wine and port merchant has received distressing news that her lover, Walter, has married a wealthy heiress. In her anguish she takes her own life, leaving poor Catherine alone and heartbroken. Angry and grieving, Catherine is sent to live under the guardianship of her eccentric Aunt Lopa in a small farmhouse high above the rich vineyards of the Douro valley.

Bridget Milligan has donned a uniform and joined the nursing services where she becomes intrigued with the miracles of modern medicine. She’s also torn between family loyalty, her new career and Lyndon O’Neill, the love of her life. Is it too impossible to hope that everything will come out right in the end? Phyllis Harvey is still serving in Malta where she sees the casualties of war first hand. Finally it seems like Phyllis is blessed with true in love, but fate can sometimes be a rocky road and nothing is that certain.

May 1944. Hope and excitement is in the air when news breaks of the allied forces landing in Normandy. D Day has arrived. However, the day-to-day struggles for the Tobacco Girls continue. Peace is on the horizon, but will their wishes and dreams win through and bring them a happy ever after?

Bristol 1941. Having left her abusive husband for very good reasons, Mary Anne Randall finds herself judged harshly by her friends and neighbours, after courageously risking everything for a second chance at happiness with Michael. With Michael away fighting, Mary Anne is less concerned by her tarnished reputation and focusses on keeping her beloved children safe. But with the bombs beginning to fall on Bristol, danger is all too close to home.

Bristol 194. As the clouds of war grow bleaker both at home and abroad, the Tobacco Girls are determined to do their bit for king and country. To that end Maisie Miles and Bridget Milligan become voluntary ambulance drivers. As well as coping with the frequent air raids, Maisie is kept on her toes with three new junior employees, one of whom is particularly testing. Bridget’s heart becomes torn between family loyalty and Lyndon O’Neill III, the man she loves. Meanwhile Phyllis Harvey has joined the WAAF, opting to serve overseas whilst trying to escape her past.

May 1945 – VE Day. After battling against the odds, the three friends are uncertain of their futures. With a new dawn, there are high hopes and boundless dreams. Can the Tobacco Girls unite once more to overcome life’s troubles and find the happiness they so deserve?

The war has ended; the men are returning home to their loved ones, but for some, things have changed. Charlotte Hennessey-White's husband, David, is no longer the gentle loving man he once was and Charlotte, so independent during the war, is devastated. Edna Burbage's strong fiancée, Colin, has suffered appalling physical injuries. He won’t hold her to her promise of marriage, but she insists her feelings are unchanged. But is that true? And Polly Chandler's sweetheart, Gavin, who’d she’d planned her whole future around, hasn’t come home at all.

The Tobacco Girls cling together as they realise that the clouds of war are turning dark, the world is becoming more dangerous and their lives more unpredictable. Bridget Milligan’s big, happy family fragments when her siblings are evacuated to North Devon, then a letter from America further fills her with dismay. Maisie Miles safe haven from both Eddie Bridgeman and her father is jeopardised, and she is forced to move on, but where to this time? Phyllis Mason is struck down by tragedy, and her life spirals downwards into despair until a new horizons beckons.

Bristol 1939. At forty years of age, Mary Anne Randall still turns heads. With an abusive husband spending most of his wages on beer, she has resigned herself to be the sole breadwinner to protect her family and keep the wolves from the door. In order to make ends meet, Mary Anne runs a pawnbroking business from the wash house at the end of the garden. Following the outbreak of war an opportunity presents itself to escape her loveless marriage and find true love. Will she take that chance, or carry on living just for her children and not for herself?

The war has had a devastating effect on the Sweet family, with young Charlie Sweet, lost at sea, presumed dead and bombs falling on nearby Bristol. Still there is a glimmer of hope on the horizon in the form of Mary Sweet’s upcoming wedding to her Canadian beau. But even that has failed to rouse their father from his grief. But in London a baby has been found in a bombed out house, sheltered in the arms of his dead mother. A child to make life worth living again...

After escaping a train bound for a death camp with a trusty German Shepherd dog, a girl wakes to find that she has no memory of her former life. Lily is fostered by the kind RAF pilot who found her and his wife, Meg. It is not long before their lives are disrupted once again by the war and, with their home in ruins, they are forced to flee to the country. In the Somerset countryside, Lily is reunited with Rudy, the heroic German Shepherd.