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The fourth chronicle of Matthew Bartholomew continues the adventures of the 14th-century Cambridge physician when he is called to attend to two deaths from some poisoned wine. The opening of a new and very well-endowed college has created petty infighting amongst the academics as new appointments are made. The winter and spring have been appallingly wet, there is a fever outbreak amongst the poorer townspeople and the country is not yet fully recovered from the aftermath of the plague.

Cambridge, 1354. Christmas approaches, and the town is gripped by the worst blizzards in living memory. As the physician Matthew Bartholomew struggles to help the poorer citizens cope with freezing temperatures, his colleagues prepare for the festivities. The weather has trapped many travellers in the town, including Matthew's erstwhile love, Philippa. She and her wealthy husband are invited to Michaelhouse for the main feast, and Matthew is horrified that he does not immediately recognise the overweight, sulky woman who once stole his heart.

In 1360 Edward III issues a call to arms, as sporadic attacks by the French threaten to turn into a full-blown invasion. In Cambridge, fear of the enemy is magnified by the belief that foreign agents are lurking in the area. Tension runs ever higher as rumours and ignorance fan the flames of suspicion amid preparations for war. And then the first murder occurs - of a French scholar living in the town.

In 1360, the Great Bridge over the River Cam is close to collapse. To repair it will cost the town and the University dear, especially if its rotten wood is replaced by more durable stone. As arguments rage over raising the money other, equally heated, differences are coming to the boil over the election of a new chancellor. While the majority support Brother Michael for the post, at least one of his opponents aims to seize it by fair means or foul. Then the discovery of a body under the bridge and the disappearance of two scholars throws a more sinister shadow over both disputes.

In 1350 the people of Cambridge are struggling to overcome the effects of the Black Death - and with a high mortality rate among priests and monks, the townsfolk are vulnerable to sinister cults that have sprung up. At Michaelhouse, Matthew Bartholomew is training new physicians when the body of a friar is found in the massive chest that the university uses to store precious documents. While investigating, Bartholomew stumbles across a derelict church being used as a meeting place for the mysterious sect he believes is at the heart of a web of blackmail.

February 1355: Oxford explodes in one of the most serious riots of its history. Fearing for their lives, the scholars flee, and some choose the University at Cambridge as their temporary refuge. But they don't remain safe for long. Within hours of their arrival, the first of their number dies, followed quickly by a second. When Matthew Bartholomew begins to investigate the deaths, he uncovers evidence that the Oxford riot was not a case of random violence, but part of a carefully orchestrated plot.

Cambridge in 1352 is rife with terrible clashes between the fledgling university and the townspeople. Matthew Bartholomew, physician and teacher at Michaelhouse College, is trying to keep the peace when a student is murdered and the town plunges into chaos. At the same time, a skeleton is discovered that is rumoured to belong to a local martyr, and Bartholomew has his hands full investigating both deaths while the rioting intensifies....

Matthew Bartholomew, unorthodox but effective physician to Michaelhouse college in medieval Cambridge, is as worried as anyone about the pestilence that is ravaging Europe and seems to be approaching England. But he is distracted by the sudden and inexplicable death of the Master of Michaelhouse - a death the University authorities do not want investigated.

Michaelhouse is in uproar: Kenyngham, the saintly but ageing master, has announced his retirement, and with unseemly haste Runham arranges his own 'election' as his successor. Within days he has dismissed several members of staff, including the redoubtable laundress Agatha, and is making life so unpleasant for the scholars that even Matthew Bartholomew believes his future as physician and teacher at the college is untenable.

There is something very amiss in the finances of Michaelhouse. Despite a new influx of well-heeled students, there is an acute lack of funds for the upkeep of the buildings, even for decent provisions. It is only when the brother in charge of the account books dies unexpectedly that some sort of explanation is revealed: he has been paying large amounts of money for goods the college itself has never received.

In 1358 the fledging college of Michaelhouse in Cambridge is in need of extra funds. A legacy from the Archbishop of York of a parish close to that city promises a welcome source of income. However, there has been another claim to its ownership, and it seems the only way to settle the dispute is for a deputation from Michaelhouse to travel north. Soon Matthew Bartholomew and his colleagues learn that many of the Archbishop's executors have died in unexplained circumstances.

When a wealthy benefactor is found dead in Michaelhouse, Brother Michael and Matthew Bartholomew must find the culprit before the college is accused of foul play. At the same time, Cambridge is plagued by a mystery thief who is targeting rich pilgrims. Moreover, pranksters are at large in the university, staging a series of practical jokes that are growing increasingly dangerous and that are dividing scholars into bitterly opposed factions.

In Cambridge, 1355, the colleges of the fledgling university are as much at odds with each other as they are with the ordinary townfolk. This tension has recently been heightened by the return of two well-born murderers after receiving the King's pardon, showing no remorse but ready to confront those who helped convict them. And in the midst of this Bartholomew the physician is called to the local mill to examine two corpses. It is almost a relief to be able to turn his back on the fractious town, but as always in Cambridge nothing is disconnected.

Matthew Bartholomew jumps at the chance to travel to Ely with Brother Michael, as it will give him a unique opportunity to study in the richly stocked library of the Benedictine priory. Michael has been summoned to the city by his bishop, but it isn't until they arrive that they discover the reason - the bishop has been accused of murder. The charge seems ludicrous, but Michael takes the investigation seriously and energetically sets about his task. Almost immediately he discovers that there appears to have been a series of unexplained deaths in the area.

In 1358, over a century after its foundation in Cambridge, the college of Michael House is facing a serious shortfall of funds and competition from upstarts rivals such as Zachary Hostel. Their problems are made no easier by the hostility of the town's inhabitants, who favour the university moving away to the Fens. This simmering tension threatens to break into violence when a well-known tradesman is found dead in one of the colleges.

Believers in the theory of nominalism have set some Cambridge colleges at the throats of those who believe them to be heretics, and Michael, the senior proctor, has his work cut out to keep the peace. When a nominalist is murdered during a riot, Michael is certain he will easily find the killer amongst the Dominicans, but before he can get any sense out of them his junior proctor, Walcote, is found hanged, and he discovers that his trusted ally had arranged secret meetings at the St Ragelund Convent....

Matthew Bartholomew, doctor of medicine and fellow of Michaelhouse, Cambridge, is travelling with a party from the college to accept the gift of the living of a parish in Suffolk. One of his companions, Unwin, an unworldly scholar, is to be installed as priest. Their journey is not without incident - they are chased by footpads, pass through an eerie village abandoned after the recent plague and find a man barely alive on a gibbet - so they reach their destination with some relief. But their thoughts of recovering while enjoying the local Pentecostal Fair are soon curtailed.

Thomas Chaloner, spy for the King's intelligence service, has just returned from thwarting a planned revolt in Dublin, but soon realises that England's capital is no haven of peace. He is ordered to investigate the shooting of a beggar during a royal procession. He soon learns the man is no vagrant, but someone with links to the powerful company of Barber-Surgeons. His master, the earl of Clarendon, is locked in a deadly feud with the earl of Bristol, and an innocent man is about to be hanged in Newgate.

In the summer of 1358 the physician Matthew Bartholomew returns to Cambridge to learn that his beloved sister is in mourning after the unexpected death of her husband, Oswald Stanmore. Aware that his son has no interest in the cloth trade that made his fortune and reputation, Oswald has left the business to his widow, but a spate of burglaries in the town distracts Matthew from supporting Edith in her grief and attempting to keep the peace between her and her wayward son.

It is drawing near to the end of term, and the University at Cambridge is in turmoil over the opening of a new common library. There is an attack on one of the masters at a meeting to discuss the matter, and a body is found floating in the pond in the library's garden on the eve of its opening. Meanwhile, there are rumours of a large force of dangerous smugglers lurking in the Fens. Aided by their friend Sheriff Tulyet, Bartholomew and Michael must thwart the invaders before the Feast of Corpus Christi the following week.