History Medicine Science

Few diseases are more gruesome than typhus. Transmitted by body lice, it afflicts the dispossessed - refugees, soldiers, and ghettoized peoples - causing hallucinations, terrible headaches, boiling fever, and often death. The disease plagued the German army on the Eastern Front and left the Reich desperate for a vaccine. For this they turned to the brilliant and eccentric Polish zoologist Rudolf Weigl.

Salk became a cultural hero and icon for a whole generation. Now, at the fiftieth anniversary of the first national vaccination program, and as humanity is tantalizingly close to eradicating polio worldwide, comes this unforgettable chronicle. Salk's work was an unparalleled achievement, and it makes for a magnificent listen.

Smallpox, the only infectious disease to have been eradicated, was one of the most terrifying of human scourges. It covered the skin with hideous, painful boils, killed a third of its victims, and left the survivors disfigured for life. In this riveting, often terrifying look at the history of smallpox, Jonathan B. Tucker tells the story of this deadly disease, the heroic efforts to eradicate it worldwide, and the looming dangers it still poses today.

A vibrant young Hispano woman, Shonnie Medina, inherits a breast-cancer mutation known as BRCA1.185delAG. It is a genetic variant characteristic of Jews. The Medinas knew they were descended from Native Americans and Spanish Catholics, but they did not know that they had Jewish ancestry as well. The mutation most likely sprang from Sephardic Jews hounded by the Spanish Inquisition. The discovery of the gene leads to a fascinating investigation of cultural history and modern genetics by Dr. Harry Ostrer and other experts on the DNA of Jewish populations.

Humankind has always wrestled with the existence of suffering. For two centuries, many American ministers, physicians, and scientists believed that an omnipotent and omniscient God created the world such that people might relieve suffering through ingenuity and learning. Others responded to the new worldview introduced by the scientific revolution as a threat to the divine order. In Imagining Progress, Kristin Johnson traces the history of Americans' evolving relationship with science and religion at "one of its most dramatic places"—the bedsides of dying children.

Almost daily, headlines announce newly discovered links between cancers and their genetic causes. Science journalist Jessica Wapner vividly relates the backstory behind those headlines, reconstructing the crucial breakthroughs, explaining the science behind them, and giving due to the dozens of researchers, doctors, and patients whose curiosity and determination restored the promise of a future to the more than 50,000 people diagnosed each year with chronic myeloid leukemia (CML).

One hundred years after a milestone medical discovery, Insulin: The Crooked Timber tells the story of how insulin was transformed from what one clinician called "thick brown muck" into the very first drug to be produced using genetic engineering, one which would earn the founders of the US biotech company Genentech a small fortune. Taking the listener on a fascinating journey, starting with the discovery of insulin in the 1920s through to the present day, the book reveals a story of monstrous egos, toxic career rivalries, and a few unsung heroes.

When British-born Elizabeth Blackwell earned her medical degree in America in 1849, there was an international outcry. Few at the time would have disagreed with the actress Fanny Kemble's remark - "What, trust a woman doctor - never!"

In January 2020, leading epidemiologist Professor Mark Woolhouse learned of a new virus taking hold in China. He immediately foresaw a hard road ahead for the entire world, and emailed the Chief Medical Officer of Scotland warning that the UK should urgently begin preparations. A few days later he received a polite reply stating only that everything was under control.

The birth of psychiatry in the early nineteenth-century fundamentally changed how madness was categorized and understood. A century on, their conceptions of mental illness continue to influence our views today. Beliefs and behavior were divided up into the pathological and the healthy. The influence of religion and the supernatural became significant measures of insanity in individuals, countries, and cultures. Troubled by Faith explores these ideas about the supernatural across society through the prism of medical history.

Ignác Semmelweis is remembered for the now-commonplace notion that doctors must wash their hands before examining patients. In mid-19th century Vienna, however, this was a subversive idea. With deaths from childbed fever exploding, Semmelweis discovered that doctors themselves were spreading the disease. While his simple reforms worked immediately - childbed fever in Vienna all but disappeared - they brought down upon Semmelweis the wrath of the establishment, and led to his tragic end.

In the early 1960s, Dr. Frances Oldham Kelsey of the U.S. Food and Drug Administration became one of the most celebrated women in America when she prevented a deadly sedative from entering the U.S. market. A Canadian-born pharmacologist and physician, Kelsey saved countless Americans from the devastating side effects of thalidomide, routinely given to pregnant women to prevent morning sickness. As the FDA medical officer charged with reviewing Merrell Pharmaceutical’s application for approval, Kelsey was unconvinced that there was sufficient evidence of the drug’s efficacy and safety.

Alles begann mit einer Doktorarbeit und der Entdeckung des medizinischen Potenzials des Botenmoleküls messenger RNA. Am Ende stehen prominente Investoren wie Dietmar Hopp oder die Gates-Stiftung, Hunderte Millionen staatlicher Finanzierung, der Aufstieg zum Börsenstar und zum erfolgreichen Impfstoffentwickler. Dazwischen liegt ein steiniger Weg auf der Suche nach Unterstützung. Biotech-Unternehmer Wolfgang Klein hat die Anfangszeit als Finanzchef von CureVac selbst miterlebt. Er erzählt die einzigartige und anekdotenreiche Geschichte auf dem Weg zum Weltunternehmen.

Bart Stupak, a nine-term Democratic Congressman from Michigan’s First Congressional District, brought two unshakable principles with him to Capitol Hill in 1992: a firm belief in the sanctity of life, and the conviction that health care was a right for all Americans and not a privilege for the fortunate few. Studies indicating that 45,000 Americans died needlessly every year for lack of access to health care inspired Congressman Stupak’s tireless efforts, often at great personal cost, to pass lifesaving legislation while remaining true to his right-to-life principles.

Decades of data cannot be ignored: African-American adults are far more likely to develop Type 2 diabetes than white adults. In a rousing indictment of the idea that notions of biological race should drive scientific inquiry, Sweetness in the Blood provides an ethnographic picture of biotechnology's framings of Type 2 diabetes risk and race and, importantly, offers a critical examination of the assumptions behind the recruitment of African American and African-descent populations for Type 2 diabetes research.

When Dr. David Hosack tilled the country's first botanical garden in the Manhattan soil more than 200 years ago, he didn't just dramatically alter the New York landscape; he left a monumental legacy of advocacy for public health and wide-ranging support for the sciences. In melodic prose, historian Victoria Johnson eloquently chronicles Hosack's tireless career to reveal the breadth of his impact. The result is a lush portrait of the man who gave voice to a new, deeply American understanding of the powers and perils of nature.

Mysterious and misunderstood, distorted by biblical imagery of disfigurement and uncleanness, Hansen's disease or leprosy has all but disappeared from America's consciousness. In Carville, Louisiana, the closed doors of the nation's last center for the treatment of leprosy open to reveal stories of sadness, separation, and even strength in the face of what was once a life-wrenching diagnosis. Drawn from interviews with living patients and extensive research in the leprosarium's archives, Carville: Remembering Leprosy in America tells the stories of former patients.

The first major bioterror event in the United States - the anthrax attacks in October 2001 - was a clarion call for scientists who work with “hot” agents to find ways of protecting civilian populations against biological weapons. In The Demon in the Freezer, Richard Preston takes us into the heart of USAMRIID, the United States Army Medical Research Institute of Infectious Diseases at Fort Detrick, Maryland, once the headquarters of the US biological weapons program and now the epicenter of national biodefense.

Long before the U.S. government began conducting secret radiation and germ-warfare experiments, and long before the Tuskegee syphilis experiments, medical professionals had introduced—and hotly debated the ethics of—the use of human subjects in medical experiments. In Subjected to Science, Susan Lederer provides the first full-length history of biomedical research with human subjects in the earlier period, from 1890 to 1940.

Government, industry, and the medical profession, however, have a mixed record when it comes to framing policies and generating knowledge to address drug use and misuse. In Strange Trips, Lucas Richert investigates the myths, meanings, and boundaries of recreational drugs, palliative care drugs, and pharmaceuticals as well as struggles over product innovation, consumer protection, and freedom of choice in the medical marketplace.