The Aylward women of Nenagh, Tipperary, are mad about each other, but you wouldn’t always think it. You’d have to know them to know that—in spite of what the neighbors might say about raised voices and dramatic scenes—their house is a place of peace, filled with love, a refuge from the sadness and cruelty of the world. Their story begins at an end and ends at a beginning. It involves wives and widows, gunrunners and gougers, sinners and saints. It’s a story of terrible betrayals and fierce loyalties, isolation and togetherness, of transgression, forgiveness, desire, and love.

At times stern, at other times patient, at times perceptive, at other times in sad denial, Olive Kitteridge, a retired schoolteacher, deplores the changes in her little town of Crosby, Maine, and in the world at large, but she doesn’t always recognize the changes in those around her: a lounge musician haunted by a past romance; a former student who has lost the will to live; Olive’s own adult child, who feels tyrannized by her irrational sensitivities; and her husband, Henry, who finds his loyalty to his marriage both a blessing and a curse.

On a bright spring afternoon, Ciara Fay makes a split-second decision that will change everything. Grabbing an armful of clothes off the clothesline, she straps her two young daughters into her car and drives away. Head spinning, all she knows for certain is that home is no longer safe—and that this time, when she leaves, she must stay away. On the surface, she has a perfect life: her husband, Ryan, is a good provider, sometimes even kind and attentive, from a nice Irish family, and they have another baby on the way.

Madrid, 1957. Under the fascist dictatorship of General Francisco Franco, Spain is hiding a dark secret. Meanwhile, tourists and foreign businessmen flood into Spain under the welcoming promise of sunshine and wine. Among them is 18-year-old Daniel Matheson, the son of an oil tycoon, who arrives in Madrid with his parents hoping to connect with the country of his mother's birth through the lens of his camera. Photography - and fate - introduce him to Ana, whose family's interweaving obstacles reveal the lingering grasp of the Spanish Civil War.

When Jack and Elizabeth meet as college students in the gritty '90s Chicago art scene, the two quickly join forces and hold on tight, each eager to claim a place in the thriving underground scene with an appreciative kindred spirit. Fast-forward twenty years to suburban married life, and alongside the challenges of parenting, they encounter the often-baffling pursuits of health and happiness from polyamorous would-be suitors to home-renovation hysteria.