In Argus, North Dakota, a collection of people revolve around a fraught wedding. Gary Geist, a terrified young man set to inherit two farms, is desperate to marry Kismet Poe, an impulsive, lapsed Goth who can't read her future but seems to resolve his. Hugo, a gentle red-haired, home-schooled giant, is also in love with Kismet. He’s determined to steal her and is eager to be a home wrecker. Kismet's mother, Crystal, hauls sugar beets for Gary's family, and on her nightly runs, tunes into the darkness of late-night radio, sees visions of guardian angels.

Elizabeth is a demure 23-year-old wiling her life away at a dull museum job, living with her neurotic aunt, and subsisting off her dead mother’s inheritance. When Elizabeth begins to suffer terrible migraines and backaches, her aunt takes her to the doctor, then to a psychiatrist. But slowly, and with Jackson’s characteristic chill, we learn that Elizabeth is not just one girl - but four separate, self-destructive personalities.

Our narrator produces a sound from the piano no one else at the Conservatory can. She employs a technique she learned from her parents—also talented musicians—who fled China in the wake of the Cultural Revolution. But when an accident leaves her parents debilitated, she abandons her future for a job at a high-end beauty and wellness store in New York City.

In the spring of 2020, Lara’s three daughters return to the family's orchard in Northern Michigan. While picking cherries, they beg their mother to tell them the story of Peter Duke, a famous actor with whom she shared both a stage and a romance years before at a theater company called Tom Lake. As Lara recalls the past, her daughters examine their own lives and relationship with their mother, and are forced to reconsider the world and everything they thought they knew.

Julia Worthing is a mechanic, working in the Fiction Department at the Ministry of Truth. It’s 1984, and Britain (now called Airstrip One) has long been absorbed into the larger trans-Atlantic nation of Oceania. Oceania has been at war for as long as anyone can remember, and is ruled by an ultra-totalitarian Party, whose leader is a quasi-mythical figure called Big Brother. In short, everything about this world is as it is in Orwell’s 1984.