Joe works at a facility that performs human experimentation. His work just followed him home. The government wanted to unlock hidden abilities in the human mind. They put subjects in extreme sensory deprivation. All the test subjects went violently insane. But the research continued. Today it has been perfected. Almost perfected.

To serial slayer Andrew Compton, murder is an art, the most intimate art. After feigning his own death to escape from prison, Compton makes his way to the United States with the sole ambition of bringing his “art” to new heights. Tortured by his own perverse desires, and drawn to possess and destroy young boys, Compton inadvertently joins forces with Jay Byrne, a dissolute playboy who has pushed his “art” to limits even Compton hadn’t previously imagined.

Deep in the heart of Appalachia stands a crooked farmhouse miles from any road. The Morrows keep to themselves, and it's served them well so far. When girls go missing off the side of the highway, the cops don't knock on their door. Which is a good thing, seeing what's buried in the Morrows' backyard. But 19-year-old Michael Morrow isn't like the rest of his family. He doesn't take pleasure in the screams that echo through the trees.

The Emerald Lake Asylum is not a place most desire to go. Nineteen-year-old Skylenna, however, made a promise that she must keep. Once hired, she has only one purpose—prove to the council that barbaric treatments, such as waterboarding, scalding baths, and beatings, are no longer the answer. But that all takes pause when she meets the source of terror in the asylum. A patient with a split personality—on one side, he’s the bloodthirsty genius Dessin. On the other, a hidden persona that is buried deep in his subconscious.

These people will give anything for the idols they worship, be they rock stars, actors or authors. Or even serial killers. Lori is just such a fanatic. Her obsession is with Edmund Cox, a man of sadistic cruelty who butchered more than 20 women. She’s gone so far as to forge a relationship with him, visiting him in prison and sending him letters on a regular basis. She will do anything to get close to him, so when he gives her a task, she eagerly accepts it. She has no idea of the horror that awaits her.