Two half sisters, Effia and Esi, unknown to each other, are born into different villages in 18th-century Ghana. Effia is married off to an Englishman and will live in comfort in the palatial rooms of Cape Coast Castle, raising children who will be sent abroad to be educated before returning to the Gold Coast to serve as administrators of the empire. Esi, imprisoned beneath Effia in the castle's women's dungeon and then shipped off on a boat bound for America, will be sold into slavery.

Eniola is tall for his age, a boy who looks like a man. Because his father has lost his job, Eniola spends his days running errands for the local tailor, collecting newspapers, begging when he must, dreaming of a big future. Wuraola is a golden girl, the perfect child of a wealthy family. Now an exhausted young doctor in her first year of practice, she is beloved by Kunle, the volatile son of an ascendant politician.

Yinka’s Nigerian aunties frequently pray for her delivery from singledom, her work friends think she’s too traditional (she’s saving herself for marriage!), her girlfriends think she needs to get over her ex already, and the men in her life…well, that’s a whole other story. But Yinka herself has always believed that true love will find her when the time is right.

Queenie Jenkins is a 25-year-old Jamaican British woman living in London, straddling two cultures and slotting neatly into neither. She works at a national newspaper, where she’s constantly forced to compare herself to her white middle-class peers. After a messy breakup from her White long-term boyfriend, Queenie seeks comfort in all the wrong places...including several hazardous men who do a good job of occupying brain space and a bad job of affirming self-worth.

Ronke wants happily ever after and 2.2. kids. She’s dating Kayode and wants him to be “the one” (perfect, like her dead father). Her friends think he’s just another in a long line of dodgy Nigerian boyfriends. Boo has everything Ronke wants—a kind husband, gorgeous child. But she’s frustrated, unfulfilled, plagued by guilt, and desperate to remember who she used to be.