The people who call End of the Line need hope. They need reassurance that life is worth living. But some are unlucky enough to get through to Laura. Laura doesn’t want them to hope. She wants them to die. Laura hasn’t had it easy: she’s survived sickness and a difficult marriage only to find herself heading for forty, unsettled and angry. She doesn’t love talking to people worse off than she is. She craves it. But now someone’s on to her—Ryan, whose world falls apart when his pregnant wife ends her life, hand in hand with a stranger. Who was this man, and why did they choose to die together?

Sixteen-year-old Lorena Leland’s dreams of a rich and fulfilling life as a writer are dashed when the stock market crashes in 1929. Seven years into the Great Depression, Rena’s banker father has retreated into the bottle, her sister is married to a lazy charlatan and gambler, and Rena is an unemployed newspaper reporter. Eager for any writing job, Rena accepts a position interviewing former slaves for the Federal Writers’ Project. There, she meets Frankie Washington, a 101-year-old woman whose honest yet tragic past captivates Rena.

Nina can never forgive Maggie for what she did. And she can never let her leave. They say every house has its secrets, and the house that Maggie and Nina have shared for so long is no different. Except that these secrets are not buried in the past. Every other night, Maggie and Nina have dinner together. When they are finished, Nina helps Maggie back to her room in the attic, and into the heavy chain that keeps her there.

Christopher and Hannah are a happily married surgeon and nurse with picture-perfect lives. All that’s missing is a child. When Janie, an abandoned six-year-old, turns up at their hospital, Christopher forms an instant connection with her, and he convinces Hannah they should take her home as their own.

Sydney Shaw, like every single woman in New York, has terrible luck with dating. She's seen it all: men who lie in their dating profile, men who stick her with the dinner bill, and worst of all, men who can't shut up about their mothers. But finally, she hits the jackpot. Her new boyfriend is utterly perfect. He's charming, handsome, and works as a doctor at a local hospital. Sydney is swept off her feet.