Comedian Stephanie Renshaw hopes to finally get her big break in LA. A chance encounter lands her the perfect apartment close to the comedy clubs, but it comes with a catch: She needs a roommate to afford the rent. Enter Rae Coleman, a former police officer working the door at one of the top comedy clubs. After getting injured in the line of duty and losing her job with the LAPD, Rae guards her wounded soul behind a tough exterior. At first, the two clash horribly before a tentative friendship develops. Bit by bit, Steph manages to break through the walls Rae has built around her.

Ashley Tanner’s only desire after losing her father to a prescription overdose as a teenager has been to support her working-class family. Now an ambitious lawyer, she’s on the verge of achieving the coveted partnership she’s worked for her entire career. But with her goal in sight, the return of a mysterious woman from Ash’s past puts the promotion at risk and forces her to confront the sacrifices she’s made to win at all costs.

Life has become a farcical mess for icy British A-lister Elizabeth Thornton. America's most-hated villain stars in a top-rated TV medical drama that she hates. Now, she's been romantically linked to her perky, new co-star, Summer, due to the young woman's clumsiness. As a closeted actress, that's the last thing Elizabeth needs. If she could just get her dream movie role, life would be so much better. The only problem is that the eccentric French film-maker offering it insists on meeting her "girlfriend", Summer, first.

Ellie Fisher loves most things about being a nurse in the emergency department . . . just not working with Regina Novak, an icy attending physician who acts as if she's God's gift to medicine. The dislike is completely mutual. Regina thinks Ellie is a starry-eyed romantic with a sentimental attitude that has no place at work. When Regina gets talked into volunteering at a singles auction, Ellie accidentally bids on her—and ends up winning. Oops! Since the money raised is for a good cause, they reluctantly decide to go through with the dates.

A late bloomer lesbian doctor. A stepdaughter’s best friend. A taboo passion that could destroy them both. After a messy divorce, Dr. Rowan Colchester finally embraces her true self. A passionate encounter with a younger woman shakes her world. But when she discovers the complicated connection between them, she knows a future together is not in the cards.