Épisodes

  • Epigenetics in the Multi-Omic Era: Predicting Alzheimer’s Before It Starts

    Epigenetics in the Multi-Omic Era: Predicting Alzheimer’s Before It Starts
    Dec 15 2025

    Hosted on Acast. See acast.com/privacy for more information.
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    45 min
  • Transforming Breast Cancer Screening: Lessons from a Landmark Colombian Study

    Transforming Breast Cancer Screening: Lessons from a Landmark Colombian Study
    Dec 4 2025

    This podcast features George Busby discussing his work on polygenic risk scores (PRS) and their expanding role in precision medicine. He reflects on how he became interested in PRS, recent advances in methylation risk scores (MRS), and the potential of integrating PRS and MRS to improve disease prediction. The conversation highlights his breast cancer study in Colombian women, exploring its hypothesis, findings, and global relevance. Busby also addresses challenges in translating genomic research into clinical practice, efforts to enhance predictive models, and how technological evolution continues to drive innovation and future directions in genomic medicine.



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    51 min
  • Methylation Matters

    Methylation Matters
    Nov 10 2025
    This Inside Precision Medicine podcast explores how advances in DNA methylation research are transforming diabetes care. The discussion with Charlotte Ling covers motivations for focusing on methylation as valuable prognosticator of disease, the advantages of methylation risk scores (MRS) compared to polygenic risk scores (PRS), and novel gene associations linked to cardiovascular complications in diabetes. She articulates the validation needs across diverse populations, the influence of lifestyle on methylation stability, and strategies for translating these biomarkers into clinical tools. Finally, she reflects on evolving technologies, future applications of methylation biomarkers, and the potential for precision diagnostics and targeted interventions in high-risk diabetic patients.

    Hosted on Acast. See acast.com/privacy for more information.
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    43 min
  • Implementing Tumor Classification in the Lab – Practical Insights and Overcoming Barriers, community engagement

    Implementing Tumor Classification in the Lab – Practical Insights and Overcoming Barriers, community engagement
    Jun 13 2025
    Providing a roadmap for laboratories to adopt DNA methylation-based tumor classification, addressing workflow design, operational challenges, and community engagement. Discuss financial barriers and obstacles

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    31 min
  • Deep Dive - Advanced Sarcoma and other tumor Applications with Methylation Profiling

    Deep Dive - Advanced Sarcoma and other tumor Applications with Methylation Profiling
    May 22 2025
    Exploring the growing role of DNA methylation in classifying and predicting prognosis for sarcomas, while highlighting integration with array, NGS, and CNV analysis for complex profiling. And other tumors and applications

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    35 min
  • Expanding Applications and Updates in CNS Tumor Classification Guidelines – from research and boutique to broad clinical application

    Expanding Applications and Updates in CNS Tumor Classification Guidelines – from research and boutique to broad clinical application
    May 2 2025
    How DNA methylation changed clinical management of CNS tumors and is being integrated into clinical guidelines, including cIMPACT-NOW updates and the impact of technological advances.

    Hosted on Acast. See acast.com/privacy for more information.
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    42 min
  • Tumor Molecular Classifiers Offer Patients New Hope

    Tumor Molecular Classifiers Offer Patients New Hope
    Jul 24 2024

    This IPM podcast highlights the impressive work of Lucas Santana dos Santos, director of bioinformatics and an assistant professor at Northwestern University’s Feinberg School of Medicine. Professor dos Santos discusses the origins and recent developments of molecular tumor classification techniques and how analyzing epigenetic signatures is enabling clinicians to diagnose and treat cancer patients more effectively. This illuminating conversation examines how classifiers are developed and touches on the role of various technologies including the workhorse methylation microarray, in addition to the challenges of creating a universal tumor classifier.



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    35 min
  • Precision Psychiatry

    Precision Psychiatry
    Oct 11 2023
    This IPM podcast unpacks some of the important work being done by Emma Johnson PhD Assistant Professor | Department of Psychiatry Washington University School of Medicine - we discuss her mission to elucidate the genetic architecture of psychiatric disorders, particularly focusing on substance use and addictions. We hear about her ongoing research in understanding commonly used drugs such as alcohol and cannabis and the relationships between substance use disorders and other psychiatric disorders and mental health conditions, including schizophrenia, suicidal thoughts and behaviors, and chronic pain.

    Hosted on Acast. See acast.com/privacy for more information.
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    36 min
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