This episode dissects an academic systematic review with meta-analysis published in the journal Sports concerning the impact of caffeine consumption before late afternoon or evening training on athletes' subsequent sleep. The research synthesizes findings from ten studies to examine changes in both objective sleep parameters (like sleep efficiency and total sleep time) and subjective sleep experiences.

Kocak A, Georgousopoulou E, Knight-Agarwal CR, Matthews R, Minehan M. The Effect of Consuming Caffeine Before Late Afternoon/Evening Training or Competition on Sleep: A Systematic Review with Meta-Analysis. Sports. 2025;13:317. doi:10.3390/sports13090317

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This episode does a deep dive on a network meta-analysis evaluating the comparative effectiveness and optimal dosage of various exercise types—specifically aerobic training (AT), resistance training (RT), flexibility training (FT), and combined training (AT+RT)—for reducing depressive symptoms in children and adolescents. Overall, the study aims to provide evidence-based guidance for developing targeted clinical and public health strategies to manage adolescent depression through physical activity.

Cao X. Comparative effects of exercise type and dose on depression in children and adolescents: a network meta-analysis. Front Psychol. 2025;16:1632111. doi:10.3389/fpsyg.2025.1632111.

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This episode does a deep dive into a clinical trial article, "Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction." The study, known as the COLCOT trial, was a randomized, double-blind, placebo-controlled trial involving 4745 patients who had recently suffered a myocardial infarction, aiming to evaluate the effectiveness of low-dose colchicine, an anti-inflammatory medication, in preventing subsequent ischemic cardiovascular events.

Tardif JC, Kouz S, Waters DD, Bertrand OF, Diaz R, Maggioni AP, et al. Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction. N Engl J Med. 2019;381(26):2497-2505. doi:10.1056/NEJMoa1912388.

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