This episode does a deep dive into a systematic review examining the relationship between creatine and cognitive function specifically in older adults. The authors conducted a comprehensive search across eight databases to systematically examine current literature on this topic.

Marshall S, Kitzan A, Wright J, Bocicariu L, Nagamatsu LS. Creatine and cognition in aging: a systematic review of evidence in older adults. Nutr Rev. 2025;00(00):1-12. doi:10.1093/nutrit/nuaf135

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This episode dissects an academic systematic review with meta-analysis published in the journal Sports concerning the impact of caffeine consumption before late afternoon or evening training on athletes' subsequent sleep. The research synthesizes findings from ten studies to examine changes in both objective sleep parameters (like sleep efficiency and total sleep time) and subjective sleep experiences.

Kocak A, Georgousopoulou E, Knight-Agarwal CR, Matthews R, Minehan M. The Effect of Consuming Caffeine Before Late Afternoon/Evening Training or Competition on Sleep: A Systematic Review with Meta-Analysis. Sports. 2025;13:317. doi:10.3390/sports13090317

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This episode does a deep dive on a network meta-analysis evaluating the comparative effectiveness and optimal dosage of various exercise types—specifically aerobic training (AT), resistance training (RT), flexibility training (FT), and combined training (AT+RT)—for reducing depressive symptoms in children and adolescents. Overall, the study aims to provide evidence-based guidance for developing targeted clinical and public health strategies to manage adolescent depression through physical activity.

Cao X. Comparative effects of exercise type and dose on depression in children and adolescents: a network meta-analysis. Front Psychol. 2025;16:1632111. doi:10.3389/fpsyg.2025.1632111.

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This episode does a deep dive into a clinical trial article, "Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction." The study, known as the COLCOT trial, was a randomized, double-blind, placebo-controlled trial involving 4745 patients who had recently suffered a myocardial infarction, aiming to evaluate the effectiveness of low-dose colchicine, an anti-inflammatory medication, in preventing subsequent ischemic cardiovascular events.

Tardif JC, Kouz S, Waters DD, Bertrand OF, Diaz R, Maggioni AP, et al. Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction. N Engl J Med. 2019;381(26):2497-2505. doi:10.1056/NEJMoa1912388.

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This episode dissects a an article that investigates the differences in psychological factors between individuals with persistent tendinopathy and those without the condition.

Mest J, Flood A, Toufexis C, Waddington G, Malliaras P, Fearon AM. Differences in psychological factors between people with persistent tendinopathy and those without tendinopathy: A systematic review with meta-analysis. Journal of Orthopaedic & Sports Physical Therapy. Advance publication. doi:10.2519/jospt.2025.13307.

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This episode does a deep dive into an article that examines the health equivalence of different physical activity intensities—light, moderate, and vigorous—against outcomes like mortality, cancer, and cardiometabolic disease. Using accelerometer data from over 73,000 UK Biobank participants, the study objectively quantifies how many minutes of moderate or light activity are needed to equal one minute of vigorous activity. The core finding is a substantial deviation from the current public health convention of a 1:2 ratio (one minute of vigorous equals two minutes of moderate), which was based on less precise self-reported data.

Biswas, R.K., Ahmadi, M.N., Bauman, A. et al. Wearable device-based health equivalence of different physical activity intensities against mortality, cardiometabolic disease, and cancer. Nat Commun 16, 8315 (2025). https://doi.org/10.1038/s41467-025-63475-2

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This episode does a deep dive into an article titled "Relationship Between Tendon Tissue and Shoulder Disability Change During an 8-Week Exercise Intervention for Rotator Cuff Tendinopathy: An Observational Study," which was published in the PTJ: Physical Therapy & Rehabilitation Journal. This prospective longitudinal study sought to understand how changes in the supraspinatus tendon's thickness and internal architecture relate to patient-reported shoulder disability improvement during an eight-week progressive resistive exercise program for individuals with rotator cuff tendinopathy.

Vila-Dieguez O, Heindel MD, Zipser MC, Mortazavi K, Kulig K, Bashford G, et al. Relationship between tendon tissue and shoulder disability change during an 8-week exercise intervention for rotator cuff tendinopathy: an observational study. Phys Ther. 2025;105:pzaf107. doi:10.1093/ptj/pzaf107.

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This episode details experimental evidence demonstrating that paternal exercise in mice, either via treadmill training or muscle-specific genetic overexpression of PGC-1α, transmits enhanced endurance capacity and metabolic health to offspring.

Yin X, Anwar A, Yan L, Yu R, Luo Y, Shi L, et al. Paternal exercise confers endurance capacity to offspring through sperm microRNAs. Cell Metab. 2025;37:1-18. doi:10.1016/j.cmet.2025.09.003.

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