When Mouse’s dad asks her to clean out her dead grandmother's house, she says yes. After all, how bad could it be? Answer: pretty bad. Grandma was a hoarder, and her house is stuffed with useless rubbish. That would be horrific enough, but there’s more - Mouse stumbles across her step-grandfather’s journal, which at first seems to be filled with nonsensical rants...until Mouse encounters some of the terrifying things he described for herself.

In the summer of 1994, psychologist Daniel Hill buys a rustic farmhouse nestled in the rolling hills of West Virginia. Along with his wife and teenage daughter, the family uproots their lives in Ohio and moves south. They are initially seduced by the natural beauty of the country setting. That soon changes when they discover a hidden room in the basement with a well, boarded shut and adorned with crucifixes. Local legends about the previous owner being an exorcist come to light, but by then, all Hell has broken loose.

Andrew Larimer has left his past behind. Rising up the ranks in a New York law firm, and with a heavily pregnant wife, he is settling into a new life far from Kingsport, the town in which he grew up. But when he receives a late-night phone call from an old friend, he has no choice but to return home.

Deep in the heart of Appalachia stands a crooked farmhouse miles from any road. The Morrows keep to themselves, and it's served them well so far. When girls go missing off the side of the highway, the cops don't knock on their door. Which is a good thing, seeing what's buried in the Morrows' backyard. But 19-year-old Michael Morrow isn't like the rest of his family. He doesn't take pleasure in the screams that echo through the trees.

Joe works at a facility that performs human experimentation. His work just followed him home. The government wanted to unlock hidden abilities in the human mind. They put subjects in extreme sensory deprivation. All the test subjects went violently insane. But the research continued. Today it has been perfected. Almost perfected.