Wanted: Midwife/nurse practitioner in Virgin River, population 600. Make a difference against a backdrop of towering California redwoods and crystal clear rivers. Rent-free cabin included. When the recently widowed Melinda Monroe sees this ad, she quickly decides that the remote mountain town of Virgin River might be the perfect place to escape her heartache and to reenergize the nursing career she loves. But her high hopes are dashed within an hour of arriving - the cabin is a dump, the roads are treacherous, and the local doctor wants nothing to do with her.

Cassie has sworn off men after yet another bad date though, deep down, she’s still looking for Mr. Right. A long-haired, tattooed biker is definitely not him, so there’s no harm in a few Harley rides through Sonoma. Right? Julie married her high school sweetheart too young and now wonders how her life became all about leaky faucets and checkbook balances. Maybe love isn’t enough to sustain the perfect couple.

Nestled on the Oregon coast is a small town of rocky beaches and rugged charm. Locals love the land’s unspoiled beauty. Developers see it as a potential gold mine. When newcomer Hank Cooper learns he’s been left an old friend’s entire beachfront property, he finds himself with a community’s destiny in his hands. Cooper has never been a man to settle in one place, and Thunder Point was supposed to be just another quick stop. But Cooper finds himself getting involved with the town. And with Sarah Dupre, a woman as complicated as she is beautiful.

Welcome to Grace Valley, California - where blood runs thicker…ties are stronger…and love is all the more sweet. Visitors to the town often remark about the valley's peace and beauty - both of which are plentiful. Unlocked doors, front porches, pies cooling in the windows - this is country life at its finest. But visitors don't always see what lies at the heart of a community. Or just beyond.… June Hudson grew up in Grace Valley, the daughter of the town doctor. Leaving only to get her medical training, she returned home and followed in her father's footsteps.

Between the urban bustle of Denver and the high-stress environment of a career in neurosurgery, Maggie Sullivan has hit a wall. When an emergency high-risk procedure results in the death of a teenager, Maggie finds herself in the middle of a lawsuit - and experiencing levels of anxiety she's never faced before. She knows she needs to slow down before she burns out completely, and the best place she can think to do that is Sullivan's Crossing.

Nikki Burgess survived a terrible marriage and a worse divorce. She's just about given up hope of ever finding happiness. But when her ex-husband suddenly dies, she gets custody of her kids again - and a chance to start over. Dixie McPherson, on the other hand, has had way too much love. She has 11 tennis bracelets, dozens of trinkets, piles of sexy lingerie, and a tarnished reputation when all she ever wanted was true love, a partner, and a family. Carlisle Bartlett is loyal, kindhearted, and the funniest guy slinging drinks in the back of an airplane. But he has an ugly little secret. The only kind of love he's used to comes with bruises.

After her divorce, Charlene Dugan vowed never to get married again - a promise she has kept for twenty-five years. Until the fateful day she finds herself uttering the well-known phrase - "Let's get married!" Almost immediately, Charlene's seemingly perfect life begins unraveling at the seams. Daughter Stephanie's own relationship is about to disintegrate, and she might be just a teensy-weensy bit jealous of her mom. And Charlene seems to be spending more time with her ex-husband than with her fiancé, Dennis.

Clare Wilson is starting over. She's had it with her marriage to a charming serial cheater. Even her own son thinks she's given his father too many chances. With the support of her sisters, Maggie and Sarah, she's ready to move on. Facing her fortieth birthday, Clare is finally feeling the rush of unadulterated freedom. But when a near-fatal car accident lands Clare in the hospital, her life takes another detour. While recovering, Clare realizes she has the power to choose her life's path. With enthusiasm and a little envy, her sisters watch her bloom.

Adele and Justine have never been close. Born 20 years apart, Justine was already an adult when Addie was born. The sisters love each other, but they don’t really know each other. When Addie dropped out of university to care for their ailing parents, Justine, a successful lawyer, covered the expenses. It was the best arrangement at the time, but now that their parents are gone, the future has changed dramatically for both women.

Anna McNichol knows how to take charge. Raised by a single mother, she’s worked to ensure her three children have every advantage she didn’t. And while her marriage has its problems, she values commitment and believes in "till death do us part." Now an empty nester, she’s at the peak of her career and ready to seize the opportunity to focus on her future.