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When 24-year-old Susannah Cahalan woke up alone in a hospital room, strapped to her bed and unable to move or speak, she had no memory of how she’d gotten there. Days earlier, she had been on the threshold of a new, adult life: At the beginning of her first serious relationship and a promising career at a major New York newspaper. Now she was labeled violent, psychotic, a flight risk. What happened?

For centuries, doctors have struggled to define mental illness - how do you diagnose it, how do you treat it, how do you even know what it is? In search of an answer, in the 1970s a Stanford psychologist named David Rosenhan and seven other people - sane, normal, well-adjusted members of society - went undercover into asylums around America to test the legitimacy of psychiatry's labels. Rosenhan's watershed study broke open the field of psychiatry, closing down institutions and changing mental health diagnosis forever.

Rosemary Woodruff Leary has been known only as the wife of Timothy Leary, the Harvard professor-turned-psychedelic high priest, whose jailbreak captivated the counterculture and whose life on the run with Rosemary inflamed the government. But Rosemary was more than a mere accessory. She was a beatnik, a psychonaut, and a true believer who tested the limits of her mind and the expectations for women of her time.

Uma jovem jornalista com uma carreira promissora em Nova York se vê aprisionada em sua própria insanidade com uma doença que nenhum médico consegue diagnosticar. A rotina no jornal onde ela trabalha é substituída por inexplicáveis alucinações, surtos e ataques de paranoia – os mesmos...