Dr. Jonathan Downar, Psychiatrist and Associate Professor at the University of Toronto, joins neurocare’s Dr. Trevor Brown to discuss a groundbreaking new approach to Transcranial Magnetic Stimulation (TMS). The "ONE-D Trial" explores an accelerated, single-day TMS protocol designed to optimize neuroplasticity and enhance treatment outcomes for depression.

Unlike traditional TMS protocols requiring weeks of daily sessions, the ONE-D protocol delivers 20 sessions of intermittent theta burst stimulation (iTBS) over a single day, combined with D-cycloserine to boost neuroplasticity. Early findings indicate a delayed but robust treatment response, with remission rates increasing over six weeks post-treatment.

In this conversation, Dr. Downar explains the methodology, patient selection, and future implications of this innovative approach. They discuss how the ONE-D protocol compares to existing accelerated methods like the Stanford SAINT protocol and explore its potential applications for OCD, anxiety, and neurodegenerative disorders such as Parkinson’s and Alzheimer’s disease.

About Dr. Jonathan Downar
Dr. Downar is an Associate Professor at the University of Toronto and a leading researcher in neuromodulation and accelerated TMS protocols. His work focuses on refining non-invasive brain stimulation techniques to improve accessibility and clinical efficacy.

About the series
The neurocare group is a global network of experts in neuroscience, psychology, and neuromodulation, dedicated to advancing mental health and performance science. In this interview series, neurocare Academy lead Dr Trevor Brown interviews leading minds in this field on the state of research and effective models of care in mental health and cognitive performance. To learn more about the neurocare group and its mission visit www.neurocaregroup.com.

Are you a practitioner interested in learning how you can apply TMS and other neuromodulation techniques in your own practice? Get started with one of our online courses in neuromodulation at: www.lms.neurocaregroup.com. neurocare academy also offers in-person training and supervision in workshops throughout the world. For more information visit: www.neurocaregroup.com/academy/

If you are a patient looking for more information about these techniques or to find one of our clinics worldwide, visit www.neurocaregroup.com/patients/

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