John Perry did two things on his 75th birthday. First he visited his wife's grave. Then he joined the army. The good news is that humanity finally made it into interstellar space. The bad news is that planets fit to live on are scarce—and alien races willing to fight us for them are common. So: we fight. To defend Earth, and to stake our own claim to planetary real estate. Far from Earth, the war has been going on for decades: brutal, bloody, unyielding. Earth itself is a backwater.

Our universe is ruled by physics, and faster-than-light travel is not possible - until the discovery of The Flow, an extradimensional field we can access at certain points in space-time that transports us to other worlds, around other stars. Humanity flows away from Earth, into space, and in time forgets our home world and creates a new empire, the Interdependency, whose ethos requires that no one human outpost can survive without the others. It's a hedge against interstellar war - and a system of control for the rulers of the empire.

Not too long from today, a new, highly contagious virus makes its way across the globe. Most who get sick experience nothing worse than flu, fever, and headaches. But for the unlucky one percent - and nearly five million souls in the United States alone - the disease causes "Lock In": Victims fully awake and aware, but unable to move or respond to stimulus. The disease affects young, old, rich, poor, people of every color and creed. The world changes to meet the challenge.

The space-faring Yherajk have come to Earth to meet us and to begin humanity's first interstellar friendship. There's just one problem: They're hideously ugly and they smell like rotting fish. So getting humanity's trust is a challenge. The Yherajk need someone who can help them close the deal. Enter Thomas Stein, who knows something about closing deals. He's one of Hollywood's hottest young agents.

Ensign Andrew Dahl has just been assigned to the Universal Union Capital Ship Intrepid, flagship of the Universal Union since the year 2456. Life couldn’t be better…until Andrew begins to pick up on the facts that (1) every Away Mission involves some kind of lethal confrontation with alien forces; (2) the ship’s captain, its chief science officer, and the handsome Lieutenant Kerensky always survive these confrontations; and (3) at least one low-ranked crew member is, sadly, always killed.