Page de couverture de 317 | Nicole Rust on Why Neuroscience Hasn't Solved Brain Disorders

317 | Nicole Rust on Why Neuroscience Hasn't Solved Brain Disorders

317 | Nicole Rust on Why Neuroscience Hasn't Solved Brain Disorders

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The human brain is extremely complicated, but decades of careful neuroscientific research have revealed quite a bit about how it works, including how certain genes affect particular brain behaviors. Nevertheless, this progress has not led to quite as much improvement in the treatment of brain disorders as we might expect. I talk with neuroscientist Nicole Rust about why this is and how to improve the situation, as discussed in her new book Elusive Cures.

Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/06/09/317-nicole-rust-on-why-neuroscience-hasnt-solved-brain-disorders/

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Nicole C. Rust received her Ph.D. in neuroscience from New York University. She is currently a professor of psychology at the University of Pennsylvania. She is also a contributing editor at The Transmitter and an editor at BrainFacts.org. Among her awards are the Troland Research Award from the National Academy of Sciences.

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Ce que les auditeurs disent de 317 | Nicole Rust on Why Neuroscience Hasn't Solved Brain Disorders

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Name: Ryan Tozek. Canada,B.C. Surrey
Neurodevelopmental Disorders: Rust discusses how early brain development shapes lifelong mental health, and why disorders like autism and schizophrenia remain elusive in terms of treatment.
“Epic Tale” of Neuroscience: Despite incredible progress in understanding how the brain processes information, the field still struggles to connect this knowledge to real-world cures.
Why Bad Things Happen to Good People: They touch on the randomness and complexity of brain disorders—how even people with similar genetics or environments can have vastly different outcomes.
Reprogramming the Brain: Rust emphasizes the potential of future therapies that could “wiggle” or rewire brain circuits, but also the ethical and technical challenges involved.
Worry and Debate: The episode dives into the tension between optimism and realism in neuroscience—how much we know, how much we don’t, and whether we’re asking the right questions.
Also
The general consensus around her recent work—particularly her book Elusive Cures: Why Neuroscience Hasn’t Solved Brain Disorders and How We Can Change That—is that it offers a compelling critique of the field’s progress and a bold reimagining of how to move forward.
She argues that the brain should be understood as a complex dynamical system, which makes it incredibly difficult to control or “fix” in the traditional sense. This perspective challenges the more linear, reductionist approaches that have dominated neuroscience for decades. Her ideas are gaining traction, especially among researchers who feel that despite massive investments and technological advances, treatments for mental and neurological disorders have lagged behind expectations.
In short, Rust is seen as a thought leader pushing the field to rethink its assumptions—and many are listening.
Bravo 👌

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