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Berberine: Nature’s Metformin?

Berberine: Nature’s Metformin?

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In this deep dive episode of Daily Longevity Rx, we explore one of the most intriguing natural compounds in longevity science — berberine — and its modern pharmaceutical counterpart, metformin. From ancient roots in traditional Chinese and Ayurvedic medicine to cutting-edge clinical trials, we unpack how these two powerful molecules are transforming our understanding of metabolic health, aging, and disease prevention.

Join us as we decode:

  • How berberine works at the cellular level to reduce senescence and enhance mitochondrial health

  • Its effects on cardiac aging, including its link to the anti-aging protein Klotho

  • The parallels between berberine and metformin in regulating blood sugar, cholesterol, and inflammation

  • The role of your gut microbiome in activating berberine’s full potential

  • What the latest clinical trials say about real-world results

  • Critical cautions and interactions to be aware of before supplementing


Whether you’re looking to optimize your longevity stack or just want to understand how nature and science intersect, this episode is packed with insight.

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