Join physician assistants Helen Adams, Mount Sinai Medical Center, and Emily Przybyl, Erie County Medical Center, as they dive into the clinical complexities of chronic hepatitis B in this insightful discussion. With over 250 million people living with chronic hepatitis B worldwide, the episode emphasizes the urgency of early diagnosis, proper screening, and effective long-term monitoring to prevent progression to cirrhosis and hepatocellular carcinoma (HCC). Helen and Emily review the importance of comprehensive hepatitis B triple panel testing (surface antigen, surface antibody, core antibody), the nuances of interpreting serologies, and updated screening guidelines for high-risk populations—including pregnant women, individuals born in endemic regions, and immunocompromised patients. They also address the role of non-invasive tools like FibroScan in staging fibrosis, the risk of HBV reactivation in patients undergoing immunosuppressive therapy, and pitfalls with newer HIV regimens that lack HBV suppression. With practical advice, clinical anecdotes, and references to AASLD and AGA guidelines, this episode provides a must-hear overview for clinicians managing hepatitis B in diverse patient populations.

In this podcast episode, Future Directions in PBC Research and Management, Christina Hanson, FNP, South Denver Gastroenterology, and Patrick Horne, NP, University of Florida, explore the evolving landscape of Primary Biliary Cholangitis (PBC)—highlighting advances in biomarkers, treatment targets, and personalized care. The conversation addresses a shift in clinical thinking beyond alkaline phosphatase alone, emphasizing the role of additional markers like bilirubin, GGT, albumin, and fibrosis stage in risk stratification and treatment planning. The episode also underscores the importance of symptom assessment, especially for pruritus and fatigue, which are often underreported by patients but have a significant impact on quality of life. With the arrival of new second-line therapies and promising data from IBAT inhibitors and PARS agonists, the hosts highlight how emerging research is transforming patient management in PBC. This episode is a must-listen for clinicians seeking to optimize outcomes with a multimodal, symptom-driven approach and stay ahead of new developments in PBC treatment and clinical trials.

In this insightful discussion, nurse practitioners HoChong Gilles and Sarah Dawkins explore the critical role of multidisciplinary care in the management of Primary Biliary Cholangitis (PBC). As a complex autoimmune liver disease, PBC often requires more than hepatology alone—patients benefit from a collaborative approach that includes endocrinology for bone health, primary care for fatigue evaluation, dermatology for refractory pruritus, mental health specialists, pharmacists, social workers, cardiology, rheumatology, and registered dietitians. Gilles and Dawkins emphasize how coordinated care improves quality of life, supports symptom management, and addresses barriers to access such as medication affordability and social determinants of health. They also highlight the importance of patient advocacy groups and holistic strategies like exercise and nutritional support. This video is essential viewing for clinicians seeking to elevate outcomes and deliver patient-centered, team-based care for individuals living with chronic liver disease.