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GLP-1 & Fertility

GLP-1 & Fertility

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 Show Description In this episode of Foundations and Functions, Dr. Amick dives into a crucial and timely topic: how GLP-1 medications like Wegovy and Mounjaro—originally developed for diabetes and now widely used for weight loss—may affect fertility and pregnancy. As use among women has skyrocketed in recent years, the discussion highlights potential risks related to birth control absorption, pregnancy safety, and even IVF timing. If you're using or considering GLP-1s and fertility is part of your journey, this episode is essential listening. Plus, Rachel from the Integrative Medicine team shares how GLP-1 therapies may go beyond weight loss to support energy, inflammation reduction, and cardiovascular wellness. Whether you're exploring metabolic health options or have questions about GLP-1 safety during reproductive stages, this quick but informative conversation offers practical insights to help guide your next steps. Disclaimer: The information provided in this podcast is for educational and informational purposes only and is not intended as medical advice. The content is not a substitute for professional medical care, diagnosis, or treatment. Always seek the advice of a qualified healthcare provider with any questions you may have regarding a medical condition. If you would like more detailed medical information, please contact Integrative Medicine through their website at https://integrativemla.com/ Show Transcript 3 0:00 Welcome to Foundations and Functions weekly podcast, where we return to when medicine actually made you better. Now here's Dr. Jason Amick and Dr. C.J. 4 0:14 Pabla. 1 0:16 Welcome to Foundations and Functions. This is going to be a short talk today. I read a recent article that really caught my attention about GLP-1 medications and fertility. And those are definitely two things that we see quite a bit at our practice at Integrative Medicine Laser and Aesthetics. 1 0:33 Dr. Pava and I feel like we talk about this quite a bit every day. So, just kind of some background, these GLP-1 medications are pretty popular. You've heard of the brand names Wigovi, Monjaro, these sort of things. The generic names tend to be the sub-muglutide, the terzapatides that are out there. These are glucagon-like peptides. GLP1s mimic these hormones that are naturally occurring in our body. And what they do is they help regulate your blood sugar, they stimulate your pancreas to increase insulin when your blood sugar gets high to help regulate that blood sugar, get the sugar actually into the cells for metabolism. 1 1:16 They help control your digestion, they help control your appetite. These are naturally occurring things that our body already makes. We actually produce them in our gut. But we found a lot of benefit from using these GLP-1 agonists, these synthetic hormones that actually help regulate blood sugar. So people who are diabetics are getting a lot of benefit from that. In addition to regulating blood sugar, they're seeing some weight loss. 1 1:40 So it's kind of evolved into this, definitely this weight loss adjunct that people are getting some good benefit. And so, according to the article I read, the use among women for GLP1s from 2020 to 2023 in three short years, that number rose by 594%. So it's a pretty popular thing out there right now. And one of the things I wanted to talk to you today about is 1 2:09 how does GLP-1 agonist affect fertility? You know, there's a lot of concern with patients in our practice about fertility. And so I wanted to touch base on this with more and more women using this. 1 2:26 So the key here, there are a couple of things about this. First of all, I want to make sure that we share that because of the action of the GLP-1 actually slowing down your peristalsis, the kind of the way food moves through your stomach and your GI tract, it can actually affect your birth control. So if you're someone who isn't necessarily concerned about getting pregnant, you're actually trying to do the opposite. 1 2:47 You're trying to avoid pregnancy by taking birth control pills, but you're on the GLP-1, it can actually affect the absorption of that birth control pill. So that's a cautionary tale, things to think about out there. The other side of that is what's the risk for women taking a GLP-1 who become pregnant or during pregnancy. And this is one of those really important things in healthcare and medicine that we focus on for safety for our patients. And that is this. There's no evidence of safety. 1 3:18 The big reason is because it's hard to get pregnant women to show up to studies to see if something bad will happen to your baby. So in light of that, the general recommendation would be if you are actively trying to get pregnant, if you become pregnant or think that that may be a possibility...

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