When Luke Rosen's daughter was diagnosed with KIF1A—a rare, progressive neurological disorder—he didn't wait for answers. He and his wife built a community, launched a nonprofit, and became a driving force in rare disease research. In this episode, Luke shares how patient-led science accelerates treatments and reshapes what’s possible for families like his.

Show Notes 

Sounds of Science - N=1 Episode
Charles River | Rare Disease

Charles River | Rare Disease for Drug Discovery

Charles River | ASO Screening Services
Personalized ASO Provides Improvement for a Girl with KAND< an Ultra-rare Disease

SCA3: A Family Affair

Susannah's Superhero Story

Are we on the brink of a major shift in research? In this episode of Sounds of Science, Charles River experts challenge traditional approaches, exploring cutting-edge innovations that enhance animal welfare while driving scientific breakthroughs.

From revolutionary non-animal testing methods to advanced behavioral management strategies, we uncover how ethical care leads to better data and faster drug discovery. Tune in to discover how science, compassion, and innovation are shaping the next era of drug development.

Show Notes 

Animals in Research | 3Rs

Alternative Methods Advancement Project

CHARTER Program for Lab Animal Welfare

Advancing Responsible Science

Did you know that the first attempt at a cancer vaccine was all the way back in the 1800s? I am joined by Charles River experts Louise Brackenbury, Dan Rocca, and Mike Templin to discuss the fascinating science behind therapeutic cancer vaccines.

Clarification: Coley’s Toxin is not a vaccine in the traditional sense, but a compound developed by William Coley in the 19th century as a treatment for cancer, and is considered a precursor to modern cancer immunotherapy.