Welcome to The Pet Longevity Lab, where science meets pet wellness. In this episode, we explore the fascinating interplay of osteoclasts, osteoblasts, testosterone, and osteocalcin in bone health. Dive deep into the biology of bone remodeling, the crucial role of hormones in maintaining skeletal integrity, and how disruptions can lead to significant health challenges for both humans and pets.

We’ll uncover how testosterone stimulates bone-building cells while inhibiting bone-resorbing cells, and examine osteocalcin as a powerful marker of bone formation and its surprising connection to metabolic health. Whether you’re a pet owner, veterinary professional, or science enthusiast, this episode provides an engaging look at the critical role of hormones in shaping health and longevity.

Special thanks to researchers and veterinarians advancing this field, and join us to discover how hormonal insights are paving the way for better care and longer lives for our furry companions. Don't miss this enlightening journey into the science of bone health!

In this episode, we explore the surprising and powerful link between testosterone and inflammation—and why this matters not just for humans, but for our pets too.

Drawing from peer-reviewed human studies by Mohamad et al. and Bianchi, we break down how testosterone influences pro-inflammatory cytokines, impacts adipose tissue, and plays a key role in chronic disease prevention. You’ll learn how low testosterone levels are associated with systemic inflammation and how hormone therapy in men has shown promising results in reducing markers like IL-6, TNF-α, and CRP.

So why are we talking about this on a pet health podcast?

Because pets—especially those that are spayed or neutered—also suffer from hormone deficiency and many of the same inflammation-driven conditions: arthritis, cognitive decline, obesity, and more. This episode lays the foundation for understanding how research in human endocrinology can guide integrative, evidence-based approaches to extending pet healthspan.

🔬 Key Topics Covered:

• Testosterone’s role in immune modulation

• The connection between fat tissue, inflammation, and hormone loss

• What the human data tells us about restoring balance in neutered/spayed pets

• Why this research is central to Pet Longevity Lab’s hormone-first philosophy

🎧 If you care about science-backed pet wellness, aging, and inflammation—this episode is a must-listen.

👉 Learn more at 1mpet.org

In this episode of The Pet Longevity Lab Podcast, we explore the latest research linking testosterone, osteoarthritis, and joint health in both women and companion dogs. A recent study suggests higher testosterone levels may protect women from knee OA, while another large-scale study in dogs identifies neutering and weight gain as major OA risk factors—raising critical questions about the role of sex hormones in joint health.

Join us as we break down the science, risks, and practical takeaways for both human and veterinary medicine. Could hormone balance be the key to longevity and mobility? Tune in to find out!