In this video: Astaxanthin and Cancer Recovery | Samuel Shepherd
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What would you do if you were told you had anywhere from 10 minutes to 10 years to live?

In this episode, Dr. Barrett sit down with Samuel Shepherd, biochemical engineer, who shares his personal journey after being diagnosed with polycythemia vera, a rare blood disorder, and how that diagnosis led him to investigate the role of oxidative stress, free radicals, and cellular damage in chronic disease.

His research led him to study astaxanthin, a powerful carotenoid found in nature, and how it may influence inflammation, mitochondrial health, and oxidative balance at the cellular level.

This is not a typical supplement conversation. It's a deep dive into biochemistry, reactive oxygen species (ROS), protein misfolding, and immune signaling—and how these processes may be involved in conditions like cancer, diabetes, and neurodegenerative disease.

In this episode, we discuss:

➡️How oxidative stress and free radicals damage DNA and proteins
➡️The role of mitochondria and inflammation in chronic disease
➡️Why antioxidant defenses decline with age
➡️How protein misfolding may contribute to insulin resistance
➡️Why astaxanthin has become a major focus of his research

⚠️ Important: This episode is for educational discussion only and does not replace medical care. Cancer and chronic disease require professional diagnosis and treatment. Always consult qualified healthcare providers before making medical decisions.

If you're interested in biochemistry, longevity research, inflammation, and cellular health, this conversation will give you a new way to think about why disease develops—and what future research may reveal.

🔔 Subscribe for more conversations on cutting-edge health science and emerging medical ideas.

Follow Pod of Inquiry
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📸 Instagram: https://www.instagram.com/podofinquiry
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🔗 LinkedIn (Dr. Stephen Barrett): https://www.linkedin.com/in/stephen-barrett-92776a51/

Visit our website https://podofinquiry.com/latest-episodes/ - click on the show link to read the show notes and get more information.

Timestamps:
00:00 Introduction & Episode Overview
01:48 Sam's Medical Crisis Begins
02:43 Diagnosis: Polycythemia Vera
04:46 Treatment and Prognosis
06:30 The Question That Changed Everything
08:21 Discovery of a Common Thread
09:25 What Is Astaxanthin?
10:21 Algae Cultivation Technique
12:04 First Dosing Experiments
13:19 Dose Escalation Results
15:00 Mathematical Dose Projection
16:56 Effects at High Dose
17:04 Understanding the Mechanism
20:50 The Hydroxyl Free Radical
21:35 How Mutations Occur
22:51 Inflammation Marker Discovery
24:07 Glutathione and Aging Study
25:00 Antioxidant Decline After 50
27:07 Neutralizing Free Radicals
28:01 Commercial Production Begins
29:01 First Cancer Patient Case
29:52 High-Risk Treatment Decision
31:06 Dramatic Recovery
32:03 MD Anderson Findings
33:41 Blood Marker Discovery
35:00 Pathologist Confrontation
36:01 Expanding Treatment Cases
37:00 Glioblastoma Outcomes
37:48 Washington DC Presentation
38:57 NIH Research Funding
39:35 Diseases Linked to ROS
40:00 Protein Misfolding Mechanism
40:55 Insulin Resistance Explained
42:39 Type 2 Diabetes Effects
45:00 Alzheimer's Disease Mechanism
46:39 MIT Light Therapy Study
47:45 Non-Invasive Light Therapy
48:53 Two-Pronged Alzheimer's Strategy
49:53 The Role of ROS Balance

-- Hashtags --
#Astaxanthin #OxidativeStress #CellularHealth #LongevityScience #InflammationResearch #HealthPodcast #Biochemistry

✅StemRegen: http://www.stemregen.co/drstephen
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Your 10% discount code is POI10
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Please register your patients at - www.tremorstudy.com

What if a 5-minute test could predict—with 90% accuracy—whether a $50,000 medication will actually work for you?

In this episode, Dr. Barrett sits down with Dr. Andrew Holman, rheumatologist and CEO of Inmedix, to explore the hidden biology of stress and how it directly controls your immune system—millisecond by millisecond—through heart rate variability (HRV).

This isn't another generic "manage your stress" talk. We dive into measurable, clinical-grade HRV and how it's changing the way doctors predict treatment response in rheumatoid arthritis, autoimmune disease, and chronic pain.

In this episode, you'll learn:

➡️Why wearables like Oura Ring and Whoop don't tell the full clinical story
➡️The surprising link between sleep apnea and rheumatoid arthritis (even without snoring)
➡️How stress biologically regulates immune function in real time
➡️How an FDA-cleared HRV test measures both branches of the autonomic nervous system
➡️Why this technology could save $34 billion in healthcare costs over the next decade

The big takeaway: Stress isn't psychological—it's measurable physiology that may be sabotaging your treatment outcomes.

If you care about precision medicine, HRV, immune health, autoimmune disease, or longevity, this is a must-watch.

🔔 Subscribe for more deep dives into cutting-edge health science.

Follow Pod of Inquiry:
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🔗 LinkedIn (Dr. Stephen Barrett): https://www.linkedin.com/in/stephen-barrett-92776a51/

Visit our website https://podofinquiry.com/latest-episodes/ - click on the show link to read the show notes and get more information.

Timestamps:
00:00 Introduction & Episode Overview
01:38 Interview Begins
03:26 What Is Heart Rate Variability (HRV)?
04:02 HRV and the Autonomic Nervous System
05:00 Why HRV Matters Clinically
06:01 Consumer Wearables vs Medical-Grade HRV
08:18 Development of Cloud HRV Technology
09:33 Technical Requirements for Accurate HRV
10:00 Inside the Cloud HRV System
11:00 Measuring Both Sympathetic & Parasympathetic Systems
11:41 Interpreting Autonomic Measurements
13:09 Why HRV Matters in Medicine
14:27 Better Tools for Measuring Stress
14:41 Mainstream Recognition of Stress Biology
16:11 Vagus Nerve Stimulation & Immune Control
16:19 Medical School vs Modern Science
20:57 Clinical Applications & Treatment Strategy
22:39 Sleep Apnea and Rheumatoid Arthritis
23:07 Sleep Heart Health Study
23:31 Japanese RA Sleep Apnea Study
24:01 Effects of Treating Sleep Apnea
25:00 Key Lessons for Rheumatologists
25:45 The Future of Autonomic Medicine
27:19 Prevention & Risk Assessment
28:12 Predicting Rheumatoid Arthritis Risk
28:58 Restoring Physiologic Balance
29:09 Adoption of HRV in Clinical Practice
30:00 Availability & Insurance Coverage
31:34 Patient Perspectives on Stress
32:27 Future of Rheumatology Practice
33:08 Patient Demand & Treatment Limits
33:23 HRV as a Missing Vital Sign
34:10 Follow-Up Testing Strategies
34:44 Predicting Biologic Drug Response
36:27 Combination Therapy Study
38:58 East Meets West Medicine
39:08 Need for Objective Measurement
39:38 Restless Leg Syndrome & Nerve Entrapment
41:39 The Phoenix Sign Explained
42:14 Importance of Diagnostics
42:52 Atypical Disease Presentations
44:37 Economic Impact of Immuno-Autonomics
46:40 Autonomics Across Medicine
48:04 Stress, Strain, and Duress
48:40 Addressing Suffering in Medicine
50:00 About InMedix
51:01 Company Timeline & Funding
51:38 InMedix Mission
52:01 Business Development & Growth
53:35 Vision for the Future
53:56 Closing Remarks

-- Hashtags --
#HRV #StressScience #AutoimmuneHealth #RheumatoidArthritis #PrecisionMedicine #ImmuneSystem #LongevityScience

✅StemRegen: http://www.stemregen.co/drstephen
(Special Offer: Save 15% Using Code "SBPOD" At Checkout)
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(A Trusted Source for Natural & Synthetic Bioregulators)
✅Essential Energy : https://essentialenergy.solutions/?sca_ref=9026629.TgisoqpDPz
Your 10% discount code is POI10
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✅Approved Medical Sollutions: https://approvedmedicalsolutions.com/
(Non-licensed patients can use code "sbarrett" for a 10% discount.)
Please register your patients at - www.tremorstudy.com

What would you do if you truly believed you only had one life to live?

In this episode of Pod of Inquiry, Dr. Stephen Barrett sits down with Dr. Luke Cicchinelli, a podiatric surgeon who didn't just dream about change—he acted on it. Luke moved his family to Spain, learned Spanish through total immersion, and rebuilt his life overseas. Not once. Not twice. Three times—until it became permanent.

This conversation goes far beyond travel. It's about identity, courage, mortality, and what it really takes to live with intention.

In This Episode, You'll Discover:

➡️ How Luke learned Spanish from scratch—without apps, translators, or shortcuts
➡️ The concept of "purposeful ambiguity" and why it almost broke him
➡️ Why Spain's "work to live" culture may actually increase longevity
➡️ The #1 barrier that keeps people trapped in their comfort zones
➡️ How confronting mortality can be one of the most life-affirming experiences of all

Luke's story isn't about escaping—it's about choosing. Choosing growth over fear. Presence over routine. And giving his family the gift of cultural intelligence and a wider worldview.

If you've ever felt the pull to radically change your life—but didn't know where to start—this episode may be the permission you've been waiting for.

Follow Pod of Inquiry

📘 Facebook: https://www.facebook.com/podofinquiry
📸 Instagram: https://www.instagram.com/podofinquiry
🐦 X (Twitter): https://www.x.com/podofinquiry
🔗 LinkedIn (Dr. Stephen Barrett): https://www.linkedin.com/in/stephen-barrett-92776a51/

Visit our website https://podofinquiry.com/latest-episodes/ - click on the show link to read the show notes and get more information.

Timestamps:
01:29 - Meeting Dr. Cicchinelli
03:28 - Timeline of Moves to Spain
05:48 - Learning Spanish
08:05 - The Immersion Process
10:00 - Current Language Use at Home
12:55 - Licensing and Bureaucracy
15:00 - Healthcare System Differences
18:31 - Moving to Vigo
24:54 - Serendipitous Connections
29:09 - Regional Languages and Culture
34:05 - Language at Home
38:36 - Biggest Challenge: Purposeful Ambiguity
44:35 - Quality of Life and Community
47:13 - Professional Training Reflection
49:14 - Recipe for Transformation
53:18 - Closing Thoughts

-- Hashtags --
#IntentionalLiving #LifeTransformation #ExpatLife #LivingAbroad #PersonalGrowth #PodcastEpisode #PodOfInquiry

✅StemRegen: http://www.stemregen.co/drstephen
(Special Offer: Save 15% Using Code "SBPOD" At Checkout)
✅Nature's Marvels : https://profound-health.com/product-category/bioregulators/?aff=PODOF
(A Trusted Source for Natural & Synthetic Bioregulators)
✅Essential Energy : https://essentialenergy.solutions/?sca_ref=9026629.TgisoqpDPz
Your 10% discount code is POI10
( Photonic EMF Protection + Bio Tuning )
✅Approved Medical Sollutions: https://approvedmedicalsolutions.com/
(Non-licensed patients can use code "sbarrett" for a 10% discount.)
Please register your patients at - www.tremorstudy.com

Are you still feeling sick even after leaving the moldy environment?
You're taking supplements… maybe spending thousands on treatments… yet the symptoms won't budge.
The truth? If you're not using binders correctly, you're bailing out a sinking ship while the tap is still running.

In this week's episode, Dr. Emily Rowe reveals why binder timing is the #1 mistake keeping people stuck on what she calls "the toxic merry-go-round." Most detox protocols fail not because they're wrong… but because they're incomplete.

What You'll Learn in This Episode:

✔️ Why your liver recycles up to 95% of mold toxins back into your bloodstream
✔️ The ONE binder you can take anytime (especially for brain fog + anxiety)
✔️ The 3–5 PM "Binder Happy Hour" that boosts detox without disrupting sleep
✔️ Why detoxing too fast can actually make you sicker
✔️ The step-by-step protocol we use with sensitive patients who can't tolerate most treatments

This isn't another vague detox talk.
This is the practical, clinical roadmap to using binders the RIGHT way.

Why This Episode Matters

Binders aren't optional in mold recovery.
They are the foundation — the part almost everyone gets wrong.

If you're tired of feeling stuck, inflamed, foggy, or reactive, this episode could finally explain why… and what to do next.

Visit our website https://podofinquiry.com/latest-episodes/ - click on the show link to read the show notes and get more information.

Timestamps:
00:00 - Introduction
00:58 - Pod of Inquiry Opening
01:29 - Dr. Rowe Begins Presentation
02:30 - What Are Binders?
03:45 - Why Binders Are Crucial
04:15 - How Binders Work: Enterohepatic Circulation
05:30 - The Toxic Merry-Go-Round Problem
06:15 - Hormones and Enterohepatic Circulation
07:00 - Microplastics and Xenoestrogens
07:30 - The Overflowing Sink Analogy
08:45 - Identifying the Obstruction
09:30 - Starting Treatment with Binders
10:00 - Treating Mold Colonization
10:42 - Mold Toxin Treatment Basics (Review)
11:00 - How Binders Work (Technical)
11:53 - Binder Basics: Getting Started
12:30 - For Extremely Sensitive Individuals
13:00 - Sponsor Break: Stem Regen
14:09 - Tolerating Binders
15:00 - Individual Treatment Needs
15:30 - Common Binders Listed
16:30 - Saccharomyces Boulardii (Special Binder)
18:00 - Timing for Other Binders
19:00 - Ideal Binder Timing
20:00 - Practical Advice: Just Take Them
20:45 - TAKE THE BINDERS (Emphasis)
21:00 - Hydration and Bowel Movements
21:30 - Preventing Constipation
22:00 - Eradicating Mold Colonization
22:45 - Why Treat Colonization
23:12 - Monitoring Progress: Mycotoxin Testing
23:50 - Treatment Duration and Expectations
24:10 - Additional Resources
24:33 - Dr. Neil Nathan Mention
24:40 - Contact Information

-- Hashtags --
#moldtoxicity #detoxbinders #functionalmedicine #chronicillnessrecovery #mycotoxins #molddetox #holistichealing #DrEmilyRowe

✅StemRegen: http://www.stemregen.co/drstephen
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(A Trusted Source for Natural & Synthetic Bioregulators)
✅Essential Energy : https://essentialenergy.solutions/?sca_ref=9026629.TgisoqpDPz
Your 10% discount code is POI10
( Photonic EMF Protection + Bio Tuning )
✅Approved Medical Sollutions: https://approvedmedicalsolutions.com/
(Non-licensed patients can use code "sbarrett" for a 10% discount.)
Please register your patients at - www.tremorstudy.com

What if every cell in your body came with a built-in "expiration date"?
In this episode, I sit down with Dr. Bill Andrews — the geneticist whose team discovered telomerase, the enzyme that controls human aging and cellular lifespan.

At just 10 years old, Dr. Andrews' father told him: "You should find a cure for aging." He's spent his entire life trying to do exactly that.

In this powerful conversation, Dr. Andrews explains:

🔬 Why humans have a maximum lifespan of ~125 years — and how mathematics proves it
⏳ The "ride ticket" analogy that explains telomere shortening in under 60 seconds
💊 Why 90% of telomere supplements are scams that don't actually lengthen telomeres
🧬 What TelaVital really does — and what it can't do (yet)
♾️ How biological immortality could realistically become possible within our lifetime

One of the most shocking insights:
Many anti-aging companies don't lengthen telomeres — they just manipulate the measurements, like firing your least intelligent employees to raise your company's average IQ.

This is NOT pseudoscience. Not biohacking hype.
This is coming from the scientist who literally helped discover the enzyme that determines how long we live.

📌 If you're interested in longevity, telomeres, cellular aging, or real anti-aging science — this is a must-listen.

👍 Like, comment, and subscribe to stay updated with evidence-based conversations on health, longevity, and human optimization.

Visit our website https://podofinquiry.com/latest-episodes/ - click on the show link to read the show notes and get more information.

Timestamps:

00:00 - Introduction
01:17 - Guest Introduction & Background
01:53 - Early Interest in Aging
05:03 - The Hayflick Limit Explained
09:46 - Why Do We Age? (First Discussion)
09:58 - Graduate School & Career Path
15:24 - Telomeres Explained
22:16 - Telomeres as Scientific Fact, Not Theory
23:27 - Biological Age Testing
25:15 - DNA Methylation vs. Telomere Length
28:17 - Understanding Telomerase as an Enzyme
30:21 - What is Aging?
40:12 - Why We Age: Evolutionary Perspective
43:27 - Species-Specific Aging Mechanisms
43:53 - Maximum Human Lifespan
46:19 - Path to Immortality
46:39 - TelaVital Supplement
48:48 - How TelaVital Works
54:03 - Debunking Other Telomere Products
55:11 - Product Transparency
56:31 - Dr. Andrews' Mission
58:05 - Contact Information
58:33 - Additional Resources
59:07 - Closing

-- Hashtags --
#LongevityScience #AntiAgingBreakthrough #TelomereHealth #LiveLonger #AgingReversal #CellularAging #HumanLifespan #DrBillAndrews

✅StemRegen: http://www.stemregen.co/drstephen
(Special Offer: Save 15% Using Code "SBPOD" At Checkout)
✅Nature's Marvels : https://profound-health.com/product-category/bioregulators/?aff=PODOF
(A Trusted Source for Natural & Synthetic Bioregulators)
✅Essential Energy : https://essentialenergy.solutions/?sca_ref=9026629.TgisoqpDPz
Your 10% discount code is POI10
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✅Approved Medical Sollutions: https://approvedmedicalsolutions.com/
(Non-licensed patients can use code "sbarrett" for a 10% discount.)
Please register your patients at - www.tremorstudy.com

What if restoring your gut bacteria could rival chemotherapy—without the devastating side effects?

In this groundbreaking episode of Pod of Inquiry, Dr. Nathan Goodyear reveals how the gut microbiome, fecal transplants, and intratumoral therapies are reshaping the future of cancer treatment.

Dr. Goodyear, Medical Director at the Williams Cancer Institute, shares cutting-edge research that challenges everything we think we know about cancer, immunity, and modern oncology.

🔥 What You'll Learn in This Episode:

➡️Why 25% of 2-year-olds have zero beneficial gut bacteria—and how this ties into rising cancer rates
➡️How fecal microbiota transplants (FMT) are turning non-responders into immunotherapy responders
➡️The shocking way chemotherapy creates cell senescence, potentially sabotaging long-term immunity
➡️The cancer-parasite debate finally explained—what ivermectin & fenbendazole can and cannot do
➡️How traditional biopsies may spread cancer, and why intratumoral therapy is a paradigm shift
➡️The 53% "no evidence of disease" rate Dr. Goodyear achieved in Stage 4 prostate cancer patients
➡️Why these advanced treatments are happening in pristine facilities in Cabo, Mexico—and not the U.S.

⚠️ Why This Conversation Matters:

The current "war on cancer" is failing—and younger people are getting sick at alarming rates.
This episode breaks down why aging and cancer are fundamentally connected, why trust in medicine is collapsing, and what you can do right now to protect yourself and your loved ones.

💥 Free Resource Mentioned in the Episode

Explore The Cancer Vault—an AI-powered research tool Dr. Goodyear uses:
prescribe.com
(Dive into studies, mechanisms, and treatment pathways at your own pace.)

👉 If you're dealing with cancer, supporting someone who is, or trying to prevent it—this may be the most important conversation you hear this year.

LIKE, SUBSCRIBE, and SHARE to spread life-saving information.

Visit our website https://podofinquiry.com/latest-episodes/ - click on the show link to read the show notes and get more information.

Timestamps:
01:17 - Opening Discussion
02:35 - Williams Cancer Institute's Work
03:17 - Paradigm Shifts in Medicine
04:39 - The New Book
08:26 - Gut Microbiome and Immune System
10:00 - The My Baby Biome Study
14:08 - Fecal Transplantation Research
15:00 - Future of Fecal Transplantation
20:00 - Administration and Mechanisms
23:00 - Preventative Applications
25:00 - Chemotherapy and the Gut
25:38 - Cell Senescence Explained
30:00 - Intratumoral Approaches
35:00 - Radiation Paradox
36:31 - The Business of Medicine
40:00 - Patient Trust Crisis
42:23 - Repurposed Medications: Ivermectin
43:39 - Parasites and Cancer: Truth vs Fiction
46:02 - Effectiveness of Repurposed Drugs
50:00 - Complexity of Cancer
53:49 - The Cancer Vault Resource
55:00 - Beverly Hills vs Cabo Locations
1:00:13 - Closing

-- Hashtags --
#CancerTreatment #FecalTransplant #MicrobiomeHealth #IntegrativeOncology #Immunotherapy #GutHealth #DrNathanGoodyear

✅StemRegen: http://www.stemregen.co/drstephen
(Special Offer: Save 15% Using Code "SBPOD" At Checkout)
✅Nature's Marvels : https://profound-health.com/product-category/bioregulators/?aff=PODOF
(A Trusted Source for Natural & Synthetic Bioregulators)
✅Essential Energy : https://essentialenergy.solutions/?sca_ref=9026629.TgisoqpDPz
Your 10% discount code is POI10
( Photonic EMF Protection + Bio Tuning )
✅Approved Medical Sollutions: https://approvedmedicalsolutions.com/
(Non-licensed patients can use code "sbarrett" for a 10% discount.)
Please register your patients at - www.tremorstudy.com

Are you working harder than ever on your health… but seeing fewer results? You're not alone—and it's not your fault.

In this week's episode of Pod of Inquiry, Dr. Stephen Barrett sits down with Ben Brown, a clinical nutritionist, exercise physiologist, and functional health expert with two Master's degrees, to break down what really drives muscle growth, longevity, and sustainable health after 40.

This conversation rewrites the rules on metabolism, exercise, dieting, and long-term health.

⭐ In This Episode, You'll Learn:

✔️ Why eating MORE may be the real key to building muscle after 40
✔️ How overtraining destroys your immune system (and the signs you're doing too much)
✔️ Why restriction-based diets fail 99% of the time
✔️ The longevity supplement protocol Ben actually uses
✔️ How to dose exercise like medicine for optimal results
✔️ Why most professionals in their 40s–60s sabotage their own health without knowing it
✔️ Ben's personal journey through gut issues, H. pylori treatment, and functional medicine
✔️ How to create a sustainable health operating system that fits your life—not the other way around

🧠 Who This Episode Is For:

• Anyone 40+ trying to maintain or rebuild muscle
• High-performers struggling with energy, gut issues, or burnout
• People who keep falling off diets or training plans
• Anyone wanting longevity without extremes
• Busy professionals or executives who want to feel good and perform at a high level

🎙️ About Ben Brown

Ben Brown is a clinical nutritionist and exercise physiologist known for his systemic, non-extreme approach to health optimization. He helps executives and professionals build lasting health habits without restriction, burnout, or information overload.

🔥 If you're ready to stop doing "more" and start doing what actually works — this episode is a must-listen.

Visit our website https://podofinquiry.com/latest-episodes/ - click on the show link to read the show notes and get more information.

Timestamps:
01:08 – Guest Introduction & Background
01:48 – Ben's Origin Story
05:36 – Personal Health Journey
05:49 – Recovery Timeline
09:36 – Diet Philosophy Evolution
11:20 – Systemic Approach to Wellness
14:28 – Sustainability vs. Quick Results
20:22 – Travel & Routine Challenges
22:37 – Restriction vs. Freedom Philosophy
25:33 – "Less Is More" Paradox
28:36 – Exercise as Medicine
31:18 – Fasted vs. Fed Training
34:05 – Creatine Supplementation
35:37 – Muscle Mass & Longevity
40:04 – Muscle Loss with Aging
42:01 – Individualized Approach
46:08 – Importance of Coaching
48:51 – Desert Island Supplements
52:01 – Contact Info & Closing

-- Hashtags --
#LongevityAfter40 #MuscleAfter40 #HealthyAging #FunctionalMedicine #ExerciseAsMedicine #SustainableNutrition #BenBrown