Timestamps:

[00:01] Intro: Paul Roach, MD; Peter Schlagel, MD; Michael Riordan, Man of the People

[01:30] Short definitions of What is Cancer?

[04:30] Framing: What is life?

[04:37] Shout out to Lex Fridman's awesome Podcast- Thanks, Lex

[06:40] What is a Cell?

[07:15] Long definition of or exploration of “What is Cancer?”

[19:00] Mutations of cell signaling, growth, and, differentiation

[30:00] Detecting Cancer

[43:00] Tumor markers

[46:00] Hereditary mutations

[53:30] Genetic Testing & Counseling

[1:02:00] Genetic Signatures

[1:04:00] Smoking, Age, Obesity, Heredity

[1:10:00] The Basics

[1:12:00] Targeted Therapy

[1:16:50] Where cancer cells go wrong

[1:23:02] Benign versus Cancerous

[1:29:27] Summary and Closing

Links:

https://www.nasa.gov/vision/universe/starsgalaxies/life's_working_definition.html

https://www.quantamagazine.org/what-is-life-its-vast-diversity-defies-easy-definition-20210309/

https://youtu.be/yyBosLx7bbM

https://youtu.be/NXU_M4030nE

https://www.cancer.gov/publications/dictionaries/cancer-terms/def/cell

https://www.cancer.gov/about-cancer/understanding/what-is-cancer

References:

https://www.goodreads.com/book/show/18442853-the-molecular-basis-of-cancer?from_search=true&from_srp=true&qid=Sw4zWg3ZSp&rank=1

https://www.goodreads.com/en/book/show/61048190-devita-hellman-rosenberg-s-cancer

Key Takeaways:

“Life” as we know and accept it is the product of an intricately organized set of self-sustaining bio-chemical processes working harmoniously, with memory and the ability to carry-on over time and over new generations (Paul’s best crack at the question of “what is life?”).

Biological life is comprised of individual cells, which are extremely tiny and have three main parts: cell membrane wall around it; cytoplasm filling it up; and a nucleus as the main office or command center of the cell containing the DNA / genetic code, which determines the structure and the behavior of the cells and the tissues.

In life, that DNA/genetic code acquires (or sometimes is born with) “defects” or “mutations” which alter the shape, function, and behavior of the cell; some types of mutations [particularly those responsible for the processes/jobs of cell signaling, cell growth, and cellular differentiation] result in derangements and loss of proper cellular function —which brings its own set of problems— and also, aggressive behaviors of local invasion and distal metastasis —which, untreated, can produce organ system failure and death.

Normal cellular machinery is so complicated that there are 10,000 ways (my made up number) in which it can break down, which in short accounts for the great variability of ways...