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Your Brain Runs Your Hormones: HPO, HPA Axis & the Progesterone Connection

Your Brain Runs Your Hormones: HPO, HPA Axis & the Progesterone Connection

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In this solo episode, Lexi Burt—women’s health researcher, fertility advisor, and endometriosis advocate—dives deeper into her recent conversation with Melissa Deally on hormones, stress, and detox. Lexi unpacks the critical role of the brain in reproductive health, explains how the HPO and HPA axes are affected by chronic stress, and introduces the concept of Restorative Reproductive Medicine (RRM). She shares how low progesterone impacts fertility, cycle health, and miscarriage risk—and teaches you how to identify hormonal imbalances using simple charting tools at home. If you’re trying to conceive, managing endometriosis or PCOS, or just want to understand your cycle more deeply, this episode is a must-listen.

✨ Learn how to work with your hormones—not against them.

KEY TAKEAWAYS

1. Watch my episode with Melissa Deally

2. Recap of the conversation with Melissa Deally on hormone balance, detox, and the role of stress in women’s health

3. Introduction to Restorative Reproductive Medicine (RRM) and how it differs from conventional approaches

4. Why the brain is the control center of reproductive function

5. Understanding the HPO (Hypothalamic-Pituitary-Ovarian) and HPA (Hypothalamic-Pituitary-Adrenal) axes – and how stress impacts both

6. What is progesterone stealing and why it matters for women’s health 7. How low progesterone is linked to miscarriage risk and early pregnancy loss 8. The broader impact of low progesterone on fertility and cycle regulation 9. How to identify signs of low progesterone using charting and at-home tools


Host Bio:

Lexi Burt is a passionate advocate for holistic health, dedicated to empowering women to take charge of their well-being. As a Fertility Advisor, Endometriosis Advocate, and Researcher, Lexi specializes in helping clients manage health challenges, restore fertility, and reclaim balance through personalized strategies in nutrition, movement, and mental wellness.

With a Bachelor’s Degree in Psychology with Honours, Lexi brings a deep understanding of the mind-body connection to her coaching practice. Her love for nature and holistic living shines through in her approach, blending evidence-based methods with lifestyle philosophies like Hygge and the Blue Zones.

Based in British Columbia, Lexi finds inspiration in outdoor adventures like camping, hiking, cold-water swims, and rock climbing. She treasures time with her friends, family, her playful Corgi, and her supportive partner, drawing from these experiences to create a life rooted in joy and resilience.


Connect with Lexi:

● Instagram: @theendoadvocate | @questforwholenesspodcast

● YouTube: The Endo Advocate

● Website: lexiburt.ca


Credits

💛 Intro music cred to @chrizpychriz


Join us!

💛 Follow us on Instagram @theendoadvocate

💛 Liked what you heard? Leave a review on iTunes → A Quest for Wholeness on Apple

Podcasts

💛 Questions? Email me at lexirbut@gmail.com or DM me @theendoadvocate

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