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Publisher's Summary

“A fascinating look at how scientists are working to help doctors treat not just one disease at a time, but the aging process itself.” (Dr. Sanjay Gupta)

A startling chronicle by a brilliant young scientist takes us onto the frontiers of the science of aging, and reveals how close we are to an astonishing extension of our life spans and a vastly improved quality of life in our later years.

Aging - not cancer, not heart disease - is the true underlying cause of most human death and suffering. We accept as inevitable that as we advance in years our bodies and minds begin to deteriorate and that we are ever more likely to be felled by dementia or disease. But we never really ask - is aging necessary? Biologists, on the other hand, have been investigating that question for years. After all, there are tortoises and salamanders whose risk of dying is the same no matter how old they are. With the help of science, could humans find a way to become old without getting frail, a phenomenon known as "biological immortality"?

In Ageless, Andrew Steele, a computational biologist and science writer, takes us on a journey through the laboratories where scientists are studying every bodily system that declines with age - DNA, mitochondria, stem cells, our immune systems - and developing therapies to reverse the trend. With bell-clear writing and intellectual passion, Steele shines a spotlight on a little-known revolution already underway.

©2020 Andrew Steele (P)2020 Random House Audio

What the critics say

“During medical school we were taught that aging is a natural process and that people can simply die of old age. The thinking was that age wasn’t just a turning of the clock but an accumulation of mutations, cancer, arthritis, heart disease and dementia. Have you ever wondered, however, if it was possible to address those diseases not just individually, but collectively, by addressing the underlying process of aging itself. Sound far fetched? Well, It’s this audacious way of thinking that propelled Andrew Steele to write Ageless. In this new book, Steele highlights therapies being developed to stymie aging, from rebooting the immune system to repairing DNA to removing senescent cells. This is a fascinating look at how scientists are working to help doctors treat not just one disease at a time, but the aging process itself, helping us all to lead longer, healthier lives.” (Dr. Sanjay Gupta, Chief Medical Correspondent for CNN)

“Writing with the vim of a Bill Bryson and the technical knowledge of a scientist, Steele gives us a chance to grasp what’s at stake in this dazzling, daunting age where big data meets human biology." (The Independent)

“An optimistic exploration of aging... A diligent scientist, Steele does not ignore flops and fads... Good science in service of a convincing case that vast life extension is inevitable.” (Kirkus

What listeners say about Ageless

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  • Rod
  • 2021-04-17

Good overview but it's not for biohackers!

He speaks as though we have no tools to reduce biological aging. Usual GP recommendations.

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  • RealWoman8
  • 2021-03-31

General overview of aging and aging research

As someone who has been following what I hope will turn out to be an effective longevity protocol for the past seven years, I am an avid consumer of all books related to longevity research. Ageless is a decent, uncomplicated overview of current research into ageing. The author begins by defining ageing, discussing which animals age slowly, which age quickly and why, how environment affects longevity, etc. Then he reviews current research, such as the use of senolytics and the TAME trials that are exploring the effect of metformin on longevity. Dr. Nir Barzilai's book Age Later does a fine job exploring that in greater depth. Unlike other books (particularly David Sinclair's) that explore potentially beneficial and promising supplements such as resveratrol, NMN, and NR as well as senolytics, Andrew Steele (who does a great job reading) says don't bother, wait for more definitive science, and in the meantime, don't drink, smoke, or eat to excess, sleep well and exercise. I would imagine most people interested in longevity already do all that, and frankly, I think some supplements do show genuine promise, so I was disappointed they were summarily dismissed. Perhaps Mr. Steels will prove to be right in the long run, though. All in all, Ageless provides a conservative overview of the topic of ageing, touches on some current research, but doesn't offer anything new or insightful on the topic, beyond a plea for more research dollars to be directed toward slowing or stopping ageing - which I agree should be done. If you're looking for more detailed information about current studies, read Dr. Sinclair's or Dr. Barzilai's books.

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  • pawnsac
  • 2021-03-29

More General than Dr Sinclair's Book

At first, I thought this book would cover the same things as Dr Sinclair's book. There is some overlap, but I thought the books were different enough to warrant listening to both.

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  • Michael R. Lyner
  • 2021-11-05

Excellent, albeit technically complex in parts

Very convincing arguments for increased and rapid funding for biogerontology. Technically thorough, yet with occasional, well placed touches of humour.

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  • John K Rayburn
  • 2021-11-03

Thought provoking

Few real answers but still a good book. Hopefully more people will push for more funding on research into aging .

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  • WhiteWolf
  • 2021-08-22

Disappointed

There is nothing new here and nothing to be done about aging!!
If there is it’s not in this book

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  • V. Gutierrez-contreras
  • 2021-08-02

Uo to date; informative

Although the advances are substancial the recommendations hasn’t changed for years.
Nothing new under the sun

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  • Thomas Maufer
  • 2021-07-19

this really opened my eyes to a hidden revolution

the "story" was well told, despite occasionally being laden with very technical language. it's worth becoming aware of the mindset where aging is considered a disease, that can be cured, rather than a consequence of time passing.

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  • chinakids
  • 2021-06-10

Good performance and info

This was a very interesting listen, and provided some info that I was unaware of. That said, there are few if any prescriptive suggestions and little hope of extending life in any appreciable way for us oldsters. It does give hope that research is moving in that direction and that lifespans will eventually increase because of medical research. Some slightly gruesome experiments but really interesting conclusions.

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  • Christine
  • 2021-06-09

Heavy on science if aging

This book is loaded with scientific studies on aging but you’ll have to wait to benefit from it. Most of it holds the “promise” of extending life. As for healthy aging now, he tells us to get proper sleep, eat your veggies, don’t get fat.

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  • Jeremiah
  • 2021-05-09

very inspiration

very interesting and current. Here's to hoping we're the first ageless generation :) I am exciting to see how these studies develop