Chronic traumatic encephalopathy, or CTE, is a neurodegenerative disease linked to repeated head injuries. It has been found in professional athletes, soldiers, and others who have experienced years of those traumas. New research from Harvard Griffin GSAS alumni Chanthia Ma and Guanlan Dong may help us better understand this condition. Their study looks at the smallest units of brain biology—individual neurons—and finds surprising clues written in the DNA itself. Using single-cell genome sequencing, they discovered that neurons in people with CTE carry distinctive patterns of genetic damage—patterns that may overlap with those seen in Alzheimer’s disease. In this episode of Colloquy, Ma discusses how her work not only sheds light on how brain trauma leads to long-term decline but also hints at possible shared mechanisms across different neurodegenerative conditions.

Us against the redcoats. That's how we often think of the American Revolution. In Ken Burns’ latest film, scheduled to drop later this month on PBS, the acclaimed documentarian takes on that simplistic notion of the nation's founding and many others. The revolution was actually a civil war, Burns says, one that pitted Americans, including indigenous and Black folk, against each other as much as the British.

So, what were the divisions among the inhabitants of the British colonies and their neighbors? How did they flare into war? How did a fledgling nation with no central government or standing army defeat the world’s largest empire? And what were the contributions of indigenous and Black people and women? Philip C. Mead, PhD ’12, former chief historian and head curator of the Museum of the American Revolution in Philadelphia, weighs in.

“How long have you been in the snare of the devil?” That was the lose‑lose question asked of those—mostly women—accused of witchcraft in Essex County, where Salem Village was located, in 1692. According to the Cornell University historian Mary Beth Norton, PhD ’69, however, it was the accusers, rather than their targets, who were in the thrall of something powerful. In her 2002 Ambassador Award–winning book In the Devil’s Snare, Norton says that the Salem witchcraft crisis was driven not by a demonic force, but rather by the trauma of the nearby wars with New England’s Indigenous populations—conflicts that had been raging for many years and had left an indelible mark on many refugees who fled to towns on the North Shore of Massachusetts.