Today on The Human Upgrade, Dr. Anurag Singh, a renowned expert in muscle biology and aging, shares his expertise on the impact of GLP-1 agonists like Ozempic and Wegovy on weight loss, muscle health, and aging. In this episode, you'll learn about the science behind these popular drugs, their potential benefits, and the risks involved. Discover how you can maintain muscle mass while losing weight, enhance your mitochondrial function for better health, and what the future holds for medical treatments in weight management. Gain expert insights into making smart choices for your long-term health and wellness, whether you're considering these treatments or just curious about new health technologies.

Timestamped Highlights:

• (00:00:00) Introduction to GLP-1 agonists and their popularity in weight loss.
• (00:01:40) Guest introduction: Dr. Anurag Singh's expertise and background.
• (00:02:50) Dr. Singh discusses the primary functions and uses of GLP-1 drugs.
• (00:06:23) The significant muscle loss associated with GLP-1 drug use.
• (00:10:01) Addressing common misconceptions and concerns about GLP-1 agonists.
• (00:15:34) How GLP-1 agonists affect mitochondrial function and overall metabolism.
• (00:20:30) Comparing the effects of fasting to GLP-1 drugs on weight loss and muscle preservation.
• (00:28:43) New testing methods for mitochondrial function and their implications.
• (00:35:00) Potential future directions in GLP-1 treatment and muscle preservation strategies.
• (00:41:48) The concept of 'Ozempic face' and its effects on personal appearance and self-esteem.
• (00:50:04) Discussion on 'Urolithin A' and its role in mitochondrial health and muscle strength.
• (01:04:02) Predictions for the next innovations in weight loss and muscle health treatments.

Resources:

• Vitamin Dake | www.VitaminDAKE.com
• Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books
• Follow Dave on Instagram: @Dave.Asprey
• Follow The Human Upgrade: @TheHumanUpgradePodcast
• Want to join The Human Upgrade Podcast Live? Join Our Upgrade Collective: https://www.ourupgradecollective.com/

Sponsors:

• STEMREGEN | Go to www.STEMREGEN.CO/DAVE for 20% Off
• Timeline Nutrition | Go to www.TimelineNutrition.com/Dave for an exclusive discount.

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Get ready for a journey that takes you beyond the pain of heartbreak and into a world where loss transforms into growth with science journalist Florence Williams, who shares her personal triumph over the heartbreak of divorce, which inspired her to write a book on the subject. This episode sheds light on how heartbreak reshapes our bodies and minds. You'll gain valuable tactics for emotional healing, understand the crucial role of touch in regaining trust, and see how therapeutic practices like EMDR and rituals can offer relief. For those on the mend or helping others heal, this discussion is packed with practical advice to help you transform the trials of heartbreak into a journey of empowerment. This episode provides clear steps to recover and emerge stronger from life's emotional challenges.

Timestamp Highlights

• (00:02:26) Florence Williams’ Journey Through Divorce
• (00:07:42) Divorce as a Story of Inflammation
• (00:13:43) Rebuilding Connection Post-Heartbreak
• (00:18:02) Embracing Beauty and Awe in Healing
• (00:23:22) Therapeutic Use of Psychedelics in Overcoming Heartbreak
• (00:34:33) Reestablishing Trust After Betrayal
• (00:38:04) The Healing Power of Touch and Oxytocin
• (00:44:51) Safe Relationships and Self-Discovery Post-Divorce
• (00:50:33) Journaling as a Tool for Processing Emotions

Sponsors

• ARMRA | Go to https://www.TryARMRA.com and use code Dave for 15% off
• BEAM Minerals | Go to www.Beam Minerals.com/Dave2024 for 20% off your first order.

Resources

• Get your copy of ‘Heartbreak’ by Florence Williams: https://www.florencewilliams.com/books-2
• Florence Williams website: https://www.florencewilliams.com/
• Follow Florence Williams: @Florence999
• Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books
• Follow Dave on Instagram: @Dave.Asprey
• Follow The Human Upgrade: @TheHumanUpgradePodcast

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Managing your stress effectively and building resilience just got easier with Dr. Aditi Nerurkar's guidance on The Human Upgrade. This episode tackles 'toxic resilience,' revealing its impacts on health and well-being. You'll gain insights into the HPA axis—the body's command center for stress response—and learn practical techniques to turn stress into a growth tool. Dr. Aditi introduces the 'Rule of Two,' a simple yet powerful approach to adapting to stress and shows how neuroplasticity can retrain your brain for better stress management. You'll also discover tips for setting digital boundaries, fostering gratitude, managing a full email inbox, and understanding the connections between stress management and longevity. It's all about taking actionable steps toward a more resilient, empowered life.

Timestamp Highlights:

(00:01:21) - The Pressures of the Pandemic and the Surge in Stress

(00:02:08) - Introducing Dr. Aditi Nerurkar and Her Journey Through Burnout

(00:05:06) - The Concept of 'Toxic Resilience' and Sustainable Stress Management

(00:10:16) - The Physiological Responses to Stress and the HPA Axis

(00:12:12) - Transforming Stress from Maladaptive to Adaptive

(00:17:16) - The Importance of Understanding Personal Stress Thresholds

(00:21:06) - Empowering Change and Managing Internal Alerts

(00:25:15) - The 'Rule of Two' in Stress Adaptation

(00:32:21) - The Role of Neuroplasticity in Resilience

(00:37:13) - Combining Conventional Medicine with Stress Management Techniques

(00:39:29) - How Dr. Nerurkar Achieves an 'Inbox Zero' Lifestyle

(00:40:59) - The Connection Between Stress Management and Longevity

Sponsors

• Pendulum | Get 20% off membership at https://pendulumlife.com with code Asprey20
• Timeline Nutrition | Go to https://www.timeline.com/dave and get 10% off your first order.

Resources

• Get your copy of ‘The 5 Resets’ by Dr. Aditi Nerurkar
• Follow Dr. Aditi on Instagram: @draditinerurkar
• Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books
• Follow Dave on Instagram: @Dave.Asprey

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this special Asprey Archive episode you’ll learn that while yes, testosterone fuels energy and performance, it’s not the be-all and end-all solution for men’s health woes. A systems biology approach considers many other aspects and provides a broader perspective about what’s going on with you.

This conversation features board-certified urologist Tracy Gapin, M.D. He joined us in 2022 for this episode to discuss new ways for men to improve their health and performance. He uses epigenetic coaching, hormones, peptide therapy, biometric monitoring, and unique nutrition and lifestyle interventions.

In his book, “Male 2.0™: Cracking the Code to Limitless Health and Vitality,” he says medical school, residency training and even a two-decade career in urology and surgery specialties didn’t teach him how to get to root causes of men’s issues and solve them. He had a health crash of his own at 42. Since neither he nor his doctor had good answers, he went on a quest of discovery and change.

He founded the Gapin Institute for High Performance Medicine and created the proprietary N1 Performance Health Program to go beyond conventional options.

This conversation goes even further into what creates epigenetic signals that affect the function and expression of your genes. You’ll learn, too, that your mindset, stress and environment—and how you do or don’t control those things—have everything to do with your energy and focus. If you’re aiming for higher performance, Dr. Tracy suggests a trifecta that makes sleep a priority, builds resilience to stress, and creates consistent behaviors with intention.

Sponsors:

• EnVy | Go to https://www.envypillow.com/ and use code DAVE10 at checkout for an exclusive discount.

Resources:

Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books

Website: Gapin Institute for High Performance Medicine

Instagram: @DrTracyGapin

Instagram: @Dave.Asprey

YouTube: @DaveAspreyBPR

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In today’s episode you’ll explore the complexities of memory with Dr. Charan Ranganath, a top expert in cognitive neuroscience. This episode takes you through the fascinating ways our brains record, process, and utilize memories to navigate daily life and shape our futures. You’ll learn how memory impacts decision-making, the truth about common myths, and the role of groundbreaking research in our understanding of cognitive function. Dr. Ranganath shares insights from his book "Why We Remember," shedding light on the brain's ability to predict and prepare for what comes next. Whether you're a seasoned biohacker or just starting, this conversation offers valuable perspectives on the science of memory that will change how you think about your mind.

Timestamp highlights

• (00:01:03) The Role of Memory in Shaping Our Reality
• (00:04:51) The Truth about Remembering and Forgetting
• (00:12:27) Psychedelics, Plasticity, and the Future of Memory Research
• (00:16:32) The Ethics of Memory Enhancement
• (00:21:10) Harnessing Memory for Predicting the Future
• (00:29:17) How Memory Evolves with Age
• (00:33:27) The Power of Pattern Recognition in Human Intelligence
• (00:38:34) Debunking Memory Myths with Dr. Ranganath
• (00:40:54) The Role of Diet and Lifestyle in Memory Preservation
• (00:50:18) What 'Spider Sense' Says About Our Predictive Brains
• (00:55:10) Building a Life of Meaningful Memories
• (00:59:42) How Long Would You Want to Live if Your Memory Stayed Intact?

Sponsors

• Sunlighten | Head to Sunlighten.com/dave to save up to $600
• STEMREGEN | Go to STEMREGEN.co/Dave for 20% off

Resources

• Get your copy of 'Why We Remember' by Dr. Charan Ranganath
• Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books
• Follow Dr. Ranganath on Instagram: @TheMemoryDoc

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Join Dave Asprey for a fascinating discussion with Colleen Cutcliffe, Ph.D., on leveraging the power of GLP-1 for natural weight management and overall well-being. Discover how probiotics can naturally stimulate GLP-1 production in the body, helping reduce food cravings and maintain a healthy gut lining. We delve into the differences between pharmaceuticals and natural probiotics, the importance of GLP-1 for longevity, and practical tips for optimizing your microbiome health. Whether you're battling cravings or seeking to prevent diabetes and its associated risks, this episode sheds light on natural, effective strategies for a healthier life.

Timestamp Highlights:

(00:00:01) Introduction to GLP-1 and weight management

(00:01:06) Colleen Cutcliffe, PhD, on natural ways to stimulate GLP-1

(00:04:41) The role of microbiome in regulating GLP-1 and cravings

(00:16:00) The GLP-1 probiotic: benefits beyond weight loss

(00:34:13) Dietary interventions to support GLP-1 probiotics

(00:42:23) Personal experiences and results with GLP-1 probiotics

(00:51:01) The different pendulum products and who should take them

(00:59:23) How GLP-1 probiotics impact the gut lining and overall health

(01:03:56) GLP-1 and its connection to longevity and disease prevention

Sponsors:

Pendulum | Get 20% off membership at https://pendulumlife.com with code Asprey20

ARMRA | Go to https://www.TryARMRA.com and use code Dave for 15% off

ARRC LED | For More Information Visit ARRCLED.com

Resources:

Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books

Instagram: @Dave.Asprey

Pendulum GLP-1 Probiotics: https://pendulumlife.com (Code: Asprey20 for 20% off)

Instagram: @pendulumlifeco

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today you'll step inside the real world of fame with Ramon Hervey II, the mastermind manager behind iconic figures like Vanessa Williams, Bette Midler, and Richard Pryor. He is author of "The Fame Game: An Insider's Playbook for Earning Your 15 Minutes." With years of experience guiding celebrity journeys, Ramon dismantles the myths surrounding fame and success. In this episode, he shares invaluable insights on why pouring your heart into your work and letting excellence lead is more fulfilling and enduring than the pursuit of fame. Ramon, a Master of Media and public perception, brings a wealth of knowledge from his time shaping the narratives of household names. Get ready to redefine your ambitions and align your pursuits with the values that truly matter. You’ll step beyond the veneer of fame into a world where your achievements stand the test of time.

(00:00:06) Introduction to the complexities of fame

(00:01:06) Ramon's correction and insights into the unpredictability of fame

(00:04:04) The statistical rarity of becoming famous

(00:06:03) The truth behind fabricating fame in the entertainment industry

(00:09:18) The importance of authenticity and integrity

(00:21:54) Ramon's experience with the toxic side of fame

(00:29:32) The gratitude for positive fan interactions

(00:32:13) Ramon's advice for influencers on handling fame

(00:41:19) How industries can shift and impact your fame

(00:42:27) Dave's creation of the biohacking movement

(00:48:41) The strategic management of public image and fame

(00:52:10) The dangers of seeking fame for fame's sake

(00:58:55) The misuse of fame and its consequences

(01:07:13) The role of media and public perception

(01:14:04) Ramon's take on fame as currency and liability

(01:20:22) The Tenets of Fame - managing fame without destruction

Sponsors:

• Timeline Nutrition | Go to https://www.timeline.com/dave and get 10% off your first order
• 40 Years of Zen | Go to https://www.40YearsOfZen.com/Dave for an exclusive offer.

Resources:

• Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books
• Website: www.herveyandcompany.com
• IG - @trichemon
• FB - Ramon Hervey II
• Twitter: @coolramon

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.