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The Peptide Podcast

The Peptide Podcast

Auteur(s): The Peptide Queen
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 The Peptide Podcast is on a mission to help people enjoy making decisions about their health and wellness. Staying informed with our SIMPLE, FAST, FUN approach. We keep you up-to-date on everything peptides. From disease management and prevention to performance health, anti-aging strategies, and more. We give you accurate, unbiased information so you can choose the peptides that suit YOU best. In our casual and easy-to-understand style, we’ll help you save time and energy for what matters most. About the host: Our experienced clinical pharmacist, The Peptide Queen, knows all too well that the internet is flawed, confusing, and hard to navigate. She has over 14 years of experience in retail, hospital, and specialty pharmacy, with certifications in peptide therapy, international travel medicine, immunization delivery, and pharmacogenomics. She’s passionate about helping you stay informed, save time, and feel less overwhelmed by the amount of information (or misinformation) on the internet.This website and its content are copyright of The Peptide Podcast - All rights reserved. Any redistribution or reproduction of part or all of the contents in any form is prohibited. Entraînement physique et mise en forme Hygiène et mode de vie sain Mise en forme, régime et nutrition Médecine alternative
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  • VIP for Pain

    VIP for Pain
    Jul 24 2025
    Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. Today, we’re focusing on an often-overlooked peptide called VIP, short for Vasoactive Intestinal Peptide. The name might sound technical, but this peptide plays some important roles in the body. It helps regulate inflammation, supports nerve function, improves blood flow by relaxing blood vessels, and may even have benefits for things like chronic pain, including back pain. Let’s get into it. What is VIP? We’ve talked about VIP before on a previous podcast, but it’s been awhile and I’d like to start with the basics as a refresher. VIP is a 28-amino acid neuropeptide that acts like a signaling molecule in both the central and peripheral nervous systems. Think of it like a chemical messenger that can influence a lot of different body systems. VIP belongs to the glucagon/secretin peptide superfamily, and it’s found throughout the body, including your brain, intestines, lungs, and immune cells. Now, what does VIP actually do? Well it does quite a bit. VIP works by binding to specific receptors on cells—called VPAC1 and VPAC2—which trigger a chain reaction inside the body through something known as the cyclic AMP pathway. Once activated: It relaxes smooth muscles, which helps open up blood vessels (vasodilation) and airways (bronchodilation) It stimulates secretion of water and electrolytes in places like the gut and pancreas—so yes, it helps with digestion too It’s a major immune modulator, calming inflammation by regulating immune cell behavior Neuroprotective role, supporting the survival and adaptability of neurons VIP in Medicine – What’s the Buzz? VIP has been studied in a variety of conditions. Inflammatory diseases like rheumatoid arthritis and Crohn’s Neurodegenerative conditions like Alzheimer’s and Parkinson’s Autoimmune diseases like osteoarthritis Respiratory conditions like pulmonary arterial hypertension (PAH), asthma, and chronic obstructive pulmonary disease (COPD) or due to mold toxicity But today, we’re zooming in on something more tangible for a lot of people—back pain. VIP and Back Pain – What Do We Know? Let’s get into the science here. VIP has recently caught attention for its potential role in intervertebral disc degeneration, which is one of the top causes of chronic low back pain. A 2024 study found that VIP receptors were significantly reduced in degenerated human discs—which is kind of a red flag. When VIP was given to mice for four weeks, researchers saw slowed degeneration, better structural proteins like aggrecan, and overall healthier discs on imaging. Promising, right? But here’s the catch—this was a preclinical animal study. We still need human trials to confirm it works outside the lab. VIP and Joint Pain And when it comes to VIP and joint pain, there’s a bit more research on VIP and osteoarthritis, especially when the spine is involved. In OA models, VIP was shown to lower pro-inflammatory cytokines—those molecules that contribute to pain and make joints hurt. But here’s where it gets complicated: some studies report that VIP accumulation in joints might actually worsen pain. So... it’s a bit of a paradox. So what’s the takeaway? VIP can be helpful—but its role in pain management seems to depend on how much, where, and what kind of pain we’re talking about. VIP in Peptide Therapy – Real-World Use? In peptide clinics—especially those using integrative or regenerative medicine approaches—VIP is sometimes part of treatment protocols for nerve-related pain and inflammation. It’s often paired with other peptides like BPC-157 and TB-500. You can find some clinics that list VIP as a go-to for chronic pain, including back pain. But here’s the reality check, clinical data is limited, success is anecdotal, it’s pricey and results can vary from person to person. So while VIP might help reduce inflammation and slow tissue degeneration, it’s not a substitute for tried-and-true pain management peptides like BPC-157. Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. Until next time, be well, and as always, have a happy, healthy week.
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    5 min
  • Peptides to Help Heal Eyes

    Peptides to Help Heal Eyes
    Jul 17 2025
    Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. Today we’re going to talk about how peptides might actually help heal your eyes. If that sounds wild, stick with me. There’s some amazing early research showing how specific peptides may help with things like macular degeneration, diabetic eye disease, corneal wounds, and even age-related vision loss. We’re going to break it all down in plain language, and I’ll also explain how each peptide might actually work inside the eye. Let’s jump in. AXT107 Let’s start with AXT107 — a peptide designed to help stop the growth of abnormal blood vessels in the back of the eye. These rogue vessels are a major problem in conditions like wet macular degeneration and diabetic retinopathy. AXT107 is an injection that’s given directly into the eye that targets VEGF and angiopoietin receptors, two major players in abnormal blood vessel growth. In animal studies, it not only stopped new vessels from forming, but also reversed existing damage. Bonus? It forms a little gel-like depot in the eye that slowly releases over time, so it may last longer than current injection-based treatments. BPC-157 If you’ve heard of peptides for gut repair or injury recovery, you’ve probably come across BPC-157. But it’s also being studied for the eye, especially for corneal healing. BPC-157 eye drops seem to speed up corneal epithelial repair — that’s the outer layer of your eye — while reducing inflammation. In rat studies, it helped close up corneal wounds faster, which means it might help with things like dry eye, abrasions, or even post-surgical healing. In fact, while most corneal abrasions fully heal within one to two weeks, BPC-157 can reduce the healing time by several days. Elamipretide (SS31) — The Mitochondria Booster This next peptide is especially intriguing — Elamipretide, also known as SS31. You might remember we’ve mentioned it before for its potential in age-related and neurodegenerative conditions like Alzheimer’s and Parkinson’s. But now, researchers are also exploring its role in slowing or even reversing age-related vision decline when given as an eye or subcutaneous injection. This peptide goes deep — literally — into the mitochondria of retinal cells, helping them work more efficiently. In aging mice, Elamipretide improved contrast sensitivity and even reversed some vision loss. So it’s not just slowing decline — it may actually restore function. P21 The next peptide is P21. P21 is a neurotrophic peptide, which means it helps keep nerve cells healthy. In the eye, that’s a huge deal for preserving vision. P21 protects photoreceptors and retinal pigment cells, while also calming inflammation when given as a subcutaneous injection. In aging rats with retinal damage, it helped reduce nerve cell death and slowed degeneration. Visoluten Now let’s talk about Visoluten, an oral peptide we’ve discussed before in a previous podcast. As a refresher, it’s important to remember that Visoluten is a bioregulatory peptide that helps support the health of the retina—the part of your eye that converts light into the images you see. It works by supporting the metabolic activity of eye tissues, helping maintain healthy vision and improving the eye’s ability to adapt to stress, aging, or challenging environmental conditions. Think of it like nutritional support for the eye — especially helpful for people dealing with screen fatigue, bright light exposure, or chronic eye stress. This peptide helps support the eye’s natural metabolic activity, which is key to keeping the retina functioning well and protecting it from things like oxidative stress and environmental wear and tear. Think of it as giving your eyes extra support to stay resilient, especially when they're under strain. Visoluten may also enhance blood flow to the eye, making sure the retina gets the oxygen and nutrients it needs to work properly. That’s especially important for people with conditions like age-related macular degeneration or diabetic retinopathy, where poor circulation and tissue damage are part of the problem. Retinalamin Another oral peptide, Retinalamin, is already being used in some clinical settings — especially in parts of Europe and Asia — for retinal diseases. It helps normalize vascular permeability in the retina and supports repair mechanisms. It’s shown benefits in people with glaucoma and diabetic retinopathy, sometimes even improving visual acuity when given intramuscularly or as an injection around the eye. PEDF-Derived Peptides Here’s where things start to feel futuristic — researchers have developed peptides derived from PEDF, or pigment epithelium-derived factor. PEDF is a natural protein found in the eye — ...
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    10 min
  • SLU-PP-332

    SLU-PP-332
    Jul 11 2025
    Thank you for listening to The Peptide Podcast. If you enjoyed the show and want to support what we do, head over to our Partners Page. You'll find some amazing brands we trust—and by checking them out, you're helping us keep the podcast going. Today we’re taking a closer look at SLU-PP-332, a compound that’s gaining attention for its potential role in performance support and metabolic health. If you're interested in burning fat more efficiently, supporting your mitochondria, or taking your workouts to the next level, stick around—this one’s for you. What Is SLU-PP-332? Let’s start with the basics. SLU-PP-332 is not a peptide—it’s a small molecule compound, meaning it’s made from chemical building blocks rather than amino acids like peptides are. However, it's often used alongside peptide therapies because it works through different pathways, making it a great add-on for boosting metabolism, energy, or fat loss. It was developed as a selective agonist for a group of receptors called ERRs, which stands for Estrogen-Related Receptors. But despite the name, these are not the same as classical estrogen receptors. That’s an important distinction—SLU-PP-332 does not interact with estrogen, nor does it influence estrogen levels in the body. Instead, it targets a subset of these receptors known as ERR alpha, beta and gamma. These are known as “orphan nuclear receptors,” meaning they don’t have natural ligands but still play an important role in regulating energy metabolism—especially in tissues rich in mitochondria like skeletal muscle, the heart, and brown fat. Fun fact: SLU-PP-332 actually works the strongest on the ERR-alpha receptor. Scientists use something called an EC₅₀ to figure out how powerful a compound is—that’s just a fancy way of measuring how much you need to get half of its maximum effect. For SLU-PP-332, the EC₅₀ is only 98 nanomolar, which means it takes a super small amount to get the job done. In other words, it’s really effective even at low doses. What Is an ERR Agonist and Why Does It Matter? So what happens when we activate these receptors? As an ERR agonist, SLU-PP-332 helps upregulate pathways involved in mitochondrial biogenesis, fatty acid oxidation, and thermogenesis—the body's natural process of producing heat and burning calories. Think of it as flipping a metabolic switch that enhances your ability to use fat as fuel, improves endurance, and supports overall mitochondrial health. In other words, SLU-PP-332 has the potential to help you burn more energy, especially during movement, while also improving your metabolic efficiency at rest. Essentially, SLU-PP-332 acts like a workout for your cells—boosting how much fuel your body burns and enhancing energy use, just like physical activity does. How It Feels and Who Might Use It Most people who use SLU-PP-332 describe it as a subtle but noticeable boost in clean energy. It’s not a stimulant like caffeine, but at higher doses, it can cause mild nervous system effects such as jitteriness or restlessness—similar to how you might feel after a strong cup of coffee. Because of this, the best approach is to start low and go slow. Most users begin with an oral dose of 50 to 100 micrograms per day to assess tolerance. Timing matters, too. It’s ideal to take SLU-PP-332 before a fasted cardio session—like a morning walk or workout—because your insulin levels are lower at that time, and that enhances the fat-burning effects. Some people prefer to split their dose, taking half in the morning and the other half in the early afternoon for sustained benefit. And it’s best to cycle it. Use it for two to three weeks, then take a one- to two-week break. This helps avoid receptor desensitization and keeps the compound working effectively over time. Synergy and Stacking Potential One of the exciting things about SLU-PP-332 is how well it stacks with other metabolic enhancers. For example, it may work synergistically with L-carnitine, berberine, and even GLP-1 receptor agonists to enhance fat oxidation and mitochondrial efficiency. That said, you’ll get the best results when using it alongside a whole-foods diet, resistance training, and consistent movement. This is not a quick fix or a substitute for healthy habits—but when added to a solid foundation, it can definitely elevate your performance and results. Safety Considerations and Who Should Avoid It Generally, SLU-PP-332 is well tolerated. However, it’s not suitable for everyone. If you have a history of heart conditions—such as a recent myocardial infarction (heart attack), arrhythmias, or uncontrolled cardiovascular disease—it’s best to avoid this compound unless cleared by a healthcare provider. Some individuals may notice mild estrogen-like effects such as bloating or breast tenderness. This doesn’t mean it raises estrogen levels directly, but sensitive individuals may be more responsive to downstream effects of ...
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    7 min

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