Physical Biology

You wake up and feel a tickle in your throat. Your head hurts. You’re mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you head out the door. So what, exactly, is your immune system? In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes listeners on a journey through the fortress of the human body and its defenses.

Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells - taken without her knowledge - became one of the most important tools in medicine: The first “immortal” human cells grown in culture, which are still alive today, though she has been dead for more than 60 years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects.

We may believe that we are the masters of our fates, but in reality, we are at the mercy of hundreds of trillions of single-celled organisms that exert control over every aspect of how our minds and bodies function. These are the diverse species of microbes that work together synergistically to communicate with each other and with every system in our bodies. You are your microbiome’s home, and it wants to take care of you, but first you have to protect it. In Gut Check, Dr. Steven Gundry reveals the emerging science proving that Hippocrates was right—all disease begins in the gut.

In Cancer and the New Biology of Water, Thomas Cowan argues that this failure was inevitable because the oncogene theory is incorrect or at least incomplete and based on a flawed concept of biology in which DNA controls our cellular function and therefore our health. Instead, Dr. Cowan tells us the somatic mutations seen in cancer cells are the result of a cellular deterioration that has little to do with oncogenes, DNA, or even the nucleus.

A magnificently reported and soulfully crafted exploration of the human immune system - the key to health and wellness, life and death. An epic, first-of-its-kind audiobook, entwining leading-edge scientific discovery with the intimate stories of four individual lives, by the Pulitzer Prize-winning New York Times journalist.

The emotional trauma we suffer as children not only shapes our emotional lives as adults but also affects our physical health and overall well-being. Scientists now know on a biochemical level exactly how parents' chronic fights, divorce, death in the family, being bullied or hazed, and growing up with a hypercritical, alcoholic, or mentally ill parent can leave permanent, physical "fingerprints" on our brains.

Until recently, microglia were thought to be merely the brain’s housekeepers, helpfully removing damaged cells. But a recent groundbreaking discovery revealed them to be capable of terrifying Jekyll and Hyde behavior. When triggered - and anything that stirs up the immune system in the body can activate microglia - they can morph into destroyers, impacting a wide range of issues from memory problems and anxiety to depression and Alzheimer’s. Under the right circumstances, however, microglia can be coaxed back into being angelic healers.

In 2017, author Shanna Swan and her team of researchers completed a major study. They found that over the past four decades, sperm levels among men in Western countries have dropped by more than 50 percent. They came to this conclusion after examining 185 studies involving close to 45,000 healthy men. The result sent shockwaves around the globe - but the story didn’t end there.

Biogeography is the study of geographic variation in all characteristics of life - ranging from genetic, morphological, and behavioral variation among regional populations of a species, to geographic trends in diversity of entire communities across our planet's surface. From the ancient hunters and gatherers to the earliest naturalists, Charles Darwin, Alfred Russel Wallace, and scientists today, the search for patterns in life has provided insights that proved invaluable for understanding the natural world.

As dramatic as The Double Helix and as absorbing as The Soul of a New Machine, Natural Obsessions explores the advanced reaches of molecular biology, the nature of the human cell, and the genes that control cancer. It unforgettably portrays some of the best young scientists in the world, the rewards and discouragements of scientific research, and the very process of scientific inquiry.

Providing a cover for our delicate and intricate bodies, the skin is our largest and fastest-growing organ. We see it, touch it, and live in it every day. It is a habitat for a mesmerizingly complex world of micro-organisms and physical functions that are vital to our health and our survival. It is also a waste removal plant, a warning system for underlying disease and a dynamic immune barrier to infection. One of the first things people see about us, skin is crucial to our sense of identity, providing us with social significance and psychological meaning.

We humans like to think of ourselves as highly evolved creatures. But if we are supposedly evolution's greatest creation, why do we have such bad knees? Why do we catch head colds so often - 200 times more often than a dog does? How come our wrists have so many useless bones? And are we really supposed to swallow and breathe through the same narrow tube? Surely there's been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last.

In spring of 1918, World War I was underway, and troops at Fort Riley, Kansas, found themselves felled by influenza. By the summer of 1918, the second wave struck as a highly contagious and lethal epidemic and within weeks exploded into a pandemic, an illness that travels rapidly from one continent to another. It would impact the course of the war, and kill many millions more soldiers than warfare itself.

With curiosity and wit, Ina Park's Strange Bedfellows rips back the sheets on the mysteries of what happens when STDs enter the sack.

Cystic fibrosis was once a mysterious disease that killed infants and children. Now it could be the key to healing millions with genetic diseases of every type - from Alzheimer's and Parkinson's to diabetes and sickle cell anemia. Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope....

Millions of Americans suffer from hearing loss. Faced with the cost and stigma of hearing aids, the natural human tendency is to do nothing and hope for the best, usually while pretending that nothing is wrong. In Volume Control, David Owen argues this inaction comes with a huge social cost. He demystifies the science of hearing while encouraging listeners to get the treatment they need for hearing loss and protect the hearing they still have.

Elegantly written and deeply grounded in personal experience - works by Oliver Sacks come to mind - Physical Intelligence gives us a clear, illuminating examination of the intricate, mutually responsive relationship between the mind and the body as they engage (or don’t engage) in all manner of physical action. Ever wonder why you don’t walk into walls or off cliffs? How you decide if you can drive through a snowstorm? How high you are willing to climb up a ladder to change a lightbulb?

We have lost the war on cancer. We spend $150 billion each year treating it, yet - a few innovations notwithstanding - a patient with cancer is as likely to die of it as one was 50 years ago. Most new drugs add mere months to one's life at agonizing physical and financial cost. In The First Cell, Azra Raza offers a searing account of how both medicine and our society (mis)treats cancer, how we can do better, and why we must.

An award-winning scientist offers a groundbreaking new understanding of the mind-body connection and its profound impact on everything from advertising to romance. The human body is not just a passive device carrying out messages sent by the brain but rather an integral part of how we think and make decisions.

Little more than 100 years ago, maps of the world still boasted white space: places where no human had ever trod. Within a few short decades the most hostile of the world's environments had all been conquered. Likewise, in the 20th century, medicine transformed human life. Doctors took what was routinely fatal and made it survivable. As modernity brought us ever more into different kinds of extremes, doctors pushed the bounds of medical advances and human endurance. Extreme exploration challenged the body in ways that only the vanguard of science could answer.