In this deep dive episode of Daily Longevity Rx, we explore one of the most intriguing natural compounds in longevity science — berberine — and its modern pharmaceutical counterpart, metformin. From ancient roots in traditional Chinese and Ayurvedic medicine to cutting-edge clinical trials, we unpack how these two powerful molecules are transforming our understanding of metabolic health, aging, and disease prevention.

Join us as we decode:

• How berberine works at the cellular level to reduce senescence and enhance mitochondrial health

• Its effects on cardiac aging, including its link to the anti-aging protein Klotho

• The parallels between berberine and metformin in regulating blood sugar, cholesterol, and inflammation

• The role of your gut microbiome in activating berberine’s full potential

• What the latest clinical trials say about real-world results

• Critical cautions and interactions to be aware of before supplementing

Whether you’re looking to optimize your longevity stack or just want to understand how nature and science intersect, this episode is packed with insight.

🎙️ Episode 2 — Fasting to Last: The Longevity Science of Skipping Meals

Daily Longevity Rx

Is skipping breakfast just a trend — or the key to living longer, stronger, and sharper?

In this episode of Daily Longevity Rx, we dive deep into the science of intermittent fasting and its powerful role in reversing aging, fighting disease, and optimizing your metabolic health. From alternate-day fasting to the Fasting Mimicking Diet, we explore the latest research on how fasting affects biological age, brain performance, heart health, autophagy, and even cancer resilience.

You’ll learn:

• The three most common types of intermittent fasting (and which one is the most practical)

• What actually happens inside your cells when you stop eating

• Why ketones, BDNF, and sirtuins might be your best allies for longevity

• How to leverage timing and circadian rhythm to boost health without extreme restriction

• Who should be cautious — and why fasting isn’t one-size-fits-all

Whether you’re curious, cautious, or already fasting, this episode will leave you with clear, science-backed takeaways you can apply today.

👉 Start small. Stay consistent. Reprogram your health.

Are you a regular red meat eater wondering how to optimize your diet for long-term health? This episode dives deep into the critical balance between methionine and glycine, revealing how supplementing with glycine can be a powerful strategy to counteract potential risks associated with high methionine intake and unlock significant anti-aging benefits. Drawing on cutting-edge research, including studies from the Interventions Testing Program (ITP) and human clinical trials, we explore:

• The Methionine-Glycine Connection: Discover why high methionine levels, often found in muscle meats, can activate the mTOR pathway, which, while essential for growth, may be linked to reduced longevity when overactive. Learn how glycine helps to clear excess methionine from your body, effectively mimicking the benefits of methionine restriction without strict dietary limitations. This balancing act is crucial for optimizing your methionine to glycine ratio.
• Mechanism of Action: We break down how glycine supports longevity through multiple pathways, including:
• Autophagy Induction: Glycine is converted to sarcosine, which can stimulate autophagy—your body's cellular "self-cleaning" and recycling process, vital for removing dysfunctional components and promoting cellular health.
• Glutathione Enhancement: Glycine is a rate-limiting precursor for glutathione, the body's "master antioxidant". Restoring glutathione levels, which naturally decline with age, helps to combat oxidative stress and inflammation, two key hallmarks of aging.
• Proven Longevity Benefits: While human lifespan studies are challenging, animal models (worms, mice, and rats) consistently show that glycine supplementation extends lifespan (up to 4-6% in mice and 28-40% in rats). In humans, research on GlyNAC (a combination of glycine and N-acetylcysteine) has shown remarkable improvements in multiple age-related defects, including mitochondrial dysfunction, insulin resistance, muscle strength, gait speed, and blood pressure, effectively "reversing aging hallmarks".
• Beyond Longevity: Glycine offers a myriad of health benefits crucial for healthspan:
• Collagen Synthesis: As the most abundant amino acid in collagen, glycine is essential for maintaining youthful skin, healthy joints, tendons, and ligaments, slowing visible signs of aging like wrinkles.
• Improved Sleep Quality: Glycine acts as an inhibitory neurotransmitter, promoting relaxation and deeper, more restorative sleep by reducing core body temperature and influencing GABA pathways.
• Metabolic Health: It aids in blood sugar regulation, improves insulin sensitivity, and helps manage conditions like type 2 diabetes and metabolic syndrome.
• Liver and Heart Protection: Glycine supports liver detoxification (Phase 2), protects against alcohol-induced damage, and is associated with reduced risk factors for cardiovascular diseases.
• Muscle and Bone Health: It helps prevent sarcopenia (muscle wasting) and supports bone density, crucial for preventing fractures and maintaining physical function as you age.
• Practical Application: Learn about typical daily glycine needs, dietary sources like bone broth and collagen-rich foods, and appropriate supplementation dosages, with some experts recommending 5 to 10 grams daily for optimal health, potentially more for specific therapeutic goals.Tune in to discover why glycine might be the "unsung hero" you need in your longevity toolkit, especially if red meat is a staple in your diet!