Deep in the heart of Appalachia stands a crooked farmhouse miles from any road. The Morrows keep to themselves, and it's served them well so far. When girls go missing off the side of the highway, the cops don't knock on their door. Which is a good thing, seeing what's buried in the Morrows' backyard. But 19-year-old Michael Morrow isn't like the rest of his family. He doesn't take pleasure in the screams that echo through the trees.

Andrew McCarthy grows concerned for his family after he catches a young man, Zachary Denton, photographing his daughter, Grace McCarthy, and other children at a park. To his dismay, Zachary talks his way out of trouble when he’s confronted by the police. He hopes that’s the end of it. Then he finds Zachary at a diner and then at a grocery store. He knows their encounters aren't coincidences. And just as Andrew prepares to defend his family, Grace vanishes. 

Tamsen Donner must be a witch. That is the only way to explain the series of misfortunes that have plagued the wagon train known as the Donner Party. Depleted rations, bitter quarrels, and the mysterious death of a little boy have driven the pioneers to the brink of madness. They cannot escape the feeling that someone—or something—is stalking them. Whether it was a curse from the beautiful Tamsen, the choice to follow an experimental route West, or just bad luck - the 90 men, women, and children of the Donner Party are at the brink of one of the deadliest adventures in history.

Ana and Reid needed a lucky break. The horrifically complicated birth of their first child has left Ana paralyzed, bitter, and struggling: with mobility, with her relationship with Reid, with resentment for her baby. That's about to change with the words any New Yorker would love to hear—affordable housing lottery. They've won an apartment in the Deptford, one of Manhattan's most revered buildings. Reid dismisses disturbing events and Ana’s deep unease and paranoia as the price of living in New York—people are odd—but he can't explain the needle-like bite marks on the baby.

Working at the local processing plant, Marcos is in the business of slaughtering humans - though no one calls them that anymore. His wife has left him, his father is sinking into dementia, and Marcos tries not to think too hard about how he makes a living. After all, it happened so quickly. First, it was reported that an infectious virus has made all animal meat poisonous to humans. Then governments initiated the "Transition". Now, eating human meat - "special meat" - is legal. Marcos tries to stick to numbers, consignments, processing.